Protein Alignment HisCl1 and Glra3

DIOPT Version :9

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_536686.3
• Gene: Glra3 / 110304
• MGIID: 95749
• Length: 464
• Species: Mus musculus
• Alignment Length: 476
• Identity: 166/476 - (34%)
• Similarity: 229/476 - (48%)
• Gaps: 92/476 - (19%)

  Fly    11 FRCLI--------ALAIYLHALEQSIQHCHCVHGYRNNTESAELVSHYESSLSLPDILPIPSKTY 67
            ||.|:        ||.:.|.|.::              |.||...|...|.....|.|...:..|
Mouse     7 FRTLVSGFYFWEAALLLSLVATKE--------------TNSARSRSAPMSPSDFLDKLMGRTSGY 57

  Fly    68 DKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVD 132
            |....|...|.|..|..::.:.|..||.|.:|.|..:|||.|.|.||||...|...:.   ||:|
Mouse    58 DARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDS---LDLD 119

  Fly   133 --WLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQI 195
              .|.|||:||.||.|.|...|||::..|..|.::.:..:||..:|||.|||.|..:::|.|.|.
Mouse   120 PSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQT 184

  Fly   196 CSMMIESLSHTVEDLVFIWNMTDPLVVNTEIELPQLDISN----NYTTDCTIEYSTGNFTCLAIV 256
            |.|.:||..:|:.||:|.|....|:.|...:.|||..:..    .|   ||..|:||.|||:.:.
Mouse   185 CIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRY---CTKHYNTGKFTCIEVR 246

  Fly   257 FNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVS 321
            |:|.|::||:|...||||.|||::||:||||..:|.||||.||:|::||:.||::.|:.|||.||
Mouse   247 FHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVS 311

  Fly   322 YVKAIDVWMSSCSVFVFLSLMEFAVVNNFMG-------------PVATKAMKGYSDENISDLDDL 373
            ||||||:||:.|.:|||.:|:|:|.| ||:.             ...|:|.........||.||
Mouse   312 YVKAIDIWMAVCLLFVFSALLEYAAV-NFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDTDD- 374

  Fly   374 KSALQHHRESIIEPQYDTFCHG-----------------HATAIY-----------------IDK 404
                     .:.|.::....:|                 ||..:.                 ||.
Mouse   375 ---------EVRESRFSFTAYGMGPCLQAKDGVVPKGPNHAVQVMPKSPDEMRKVFIDRAKKIDT 430

  Fly   405 FSRFFFPFSFFILNIVYWTTF 425
            .||..||.:|.|.||.||..:
Mouse   431 ISRACFPLAFLIFNIFYWVIY 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	77/200 (39%)
		Neur_chan_memb	270..>350	CDD:280999	47/79 (59%)
Glra3	NP_536686.3	LIC	12..451	CDD:273305	163/469 (35%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O75311	235..240		3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930