Protein Alignment HisCl1 and gabrp

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: XP_017948119.2
• Gene: gabrp / 100498164
• XenbaseID: XB-GENE-1012959
• Length: 401
• Species: Xenopus tropicalis
• Alignment Length: 403
• Identity: 124/403 - (30%)
• Similarity: 205/403 - (50%)
• Gaps: 56/403 - (13%)

  Fly    65 KTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRIL 129
            |.|:|...||...:|..:...:.|.|:|:::||:|.|...|.|.|.|.|.||....|.|   ..|
 Frog    12 KDYNKYLRPKFNEKPIEIAVSLEVASIDAVSEENMDYTATINLRQRWTDERLVFEGNRS---ITL 73

  Fly   130 DVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194
            |...:.|:|.||.:..::||...|::::.|..:.|:.:.|:||..::|..::|.|....||.|.|
 Frog    74 DARLVESLWVPDTYIVDSKKSFLHDVTVENRLVRLFANGTVLYAIRITTTVACKMDLTKYPMDRQ 138

  Fly   195 ICSMMIESLSHTVEDLVFIWNMTDPLVVNTE-IELPQLDISNNYTTDCTIEYSTGNFTCLAIVFN 258
            .|.:.:||..::.:||.::|...:..|...: ::|.|..:...|||:...:..|||:..||:.|.
 Frog   139 TCKLQLESWGYSEKDLTYVWMRANDSVRGMDHLQLAQYTVEQYYTTNSIGKDETGNYPRLALCFI 203

  Fly   259 LRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVS-Y 322
            |||.:.|.:..|||||||:||:||:||||...::|||...|||::|.:.|....|:.:.|..: .
 Frog   204 LRRNVVYFILETYIPSALLVVLSWVSFWISMSSVPARTCFGVTTVLAMTTIMMGSRFNFPTANCI 268

  Fly   323 VKAIDVWMSSCSVFVFLSLMEFA----------------VVNNFMGP--------VATKA----M 359
            :|||||::..|..|||.:|:|:|                :.|:...|        :|..:    .
 Frog   269 IKAIDVYLGICFSFVFGALLEYAFAHYCSELNSAVNKEKIKNSLEEPEHDISSVLIACDSKQLNR 333

  Fly   360 KGYSDENISDLDDLKSA-----------LQHHRESIIEPQYDTFCHGHATAIYIDKFSRFFFPFS 413
            |....||..:.:.||::           ::..:.::..|:            .:|::||..||..
 Frog   334 KENQTENAPEKNSLKNSVIFKLWLKIKIIRLKKFNVTNPE------------NVDRYSRTVFPLI 386

  Fly   414 FFILNIVYWTTFL 426
            |.|:||:|||.:|
 Frog   387 FLIINIIYWTYYL 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	58/184 (32%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	39/102 (38%)
		TM1 helix	265..288	CDD:349851	15/22 (68%)
		TM2 helix	292..316	CDD:349851	9/23 (39%)
		TM3 helix	324..350	CDD:349851	13/41 (32%)
gabrp	XP_017948119.2	LIC	7..398	CDD:455710	123/400 (31%)
		LGIC_ECD	26..207	CDD:475126	58/183 (32%)