Protein Alignment HisCl1 and glra3

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: XP_002933371.1
• Gene: glra3 / 100488938
• XenbaseID: XB-GENE-1011160
• Length: 449
• Species: Xenopus tropicalis
• Alignment Length: 427
• Identity: 157/427 - (36%)
• Similarity: 220/427 - (51%)
• Gaps: 60/427 - (14%)

  Fly    41 TESAELVSHYESSLSLPDIL-PIPSKT--YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYV 102
            |:..:......|.:|..|.| .:..:|  ||....|...|.|..|..::.|.|..||.|.:|.|.
 Frog    28 TKETDSARSRPSPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFVNSFGSIAETTMDYR 92

  Fly   103 TDIFLAQSWRDPRLRLPENMSEQYRILDVD--WLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLY 165
            .:|||.|.|.||||...|...:.   ||:|  .|.|||:||.||.|.|...|||::..|..|.::
 Frog    93 LNIFLRQKWNDPRLAYSEYPDDS---LDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIF 154

  Fly   166 HDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTEIELPQ 230
            .|..:||..:|||.|||.|..:::|.|.|.|.|.:||..:|:.||:|.|....|:.:...:.|||
 Frog   155 KDGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQENGPVQIADGLTLPQ 219

  Fly   231 LDISN----NYTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEA 291
            ..:..    .|   ||..|:||.|||:.:.|:|.|::||:|...||||.|||::||:||||..:|
 Frog   220 FVLKEEKDLRY---CTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDA 281

  Fly   292 IPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVN-------- 348
            .||||.||:|::||:.||::.|:.|||.||||||||:||:.|.:|||.:|:|:|.||
 Frog   282 APARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKE 346

  Fly   349 ---------------------NF----MGPVATKAMKGYSDENISDLDDLKSALQHHRESIIEPQ 388
                                 :|    ||| ..:|..|.:.:...:........:..|:..|:
 Frog   347 LLRFRRKRKKDRDDDVRESRFSFTAYGMGP-CLQAKDGVNPKGPLNAPPAPKTHEEMRKVFID-- 408

  Fly   389 YDTFCHGHATAIYIDKFSRFFFPFSFFILNIVYWTTF 425
                     .|..||..||..||.:|.|.||.||..:
 Frog   409 ---------RAKKIDTLSRACFPLAFLIFNIFYWVIY 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	74/189 (39%)
		Cys-loop	182..196	CDD:349793	5/13 (38%)
		LGIC_TM_anion	265..>351	CDD:349851	51/118 (43%)
		TM1 helix	265..288	CDD:349851	14/22 (64%)
		TM2 helix	292..316	CDD:349851	12/23 (52%)
		TM3 helix	324..350	CDD:349851	15/54 (28%)
glra3	XP_002933371.1	LIC	12..436	CDD:273305	157/425 (37%)