Protein Alignment HisCl1 and gabrb3

DIOPT Version :10

• Sequence 1: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001096164.1
• Gene: gabrb3 / 100124708
• XenbaseID: XB-GENE-6030743
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 434
• Identity: 134/434 - (30%)
• Similarity: 214/434 - (49%)
• Gaps: 77/434 - (17%)

  Fly    65 KTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLR---LPENMSEQY 126
            |.||....|...|.|..|..::.:.|:|.::|.:|.|...::..|.|||.||.   :|.|::...
 Frog    46 KGYDIRLRPDFGGSPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYTGIPLNLTLDN 110

  Fly   127 RILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPH 191
            |:.|     .:|.||.:|.|.||...|.:::.|..:.|:.|.|:||..::|...:|.|....||.
 Frog   111 RVAD-----QLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPL 170

  Fly   192 DTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTE-IELPQLDISNNYTTDCTIEYSTGNFTCLAI 255
            |.|.|::.|||..:|.:|:.|.|...|..|...| |||||..|.::......:.::||::..|::
 Frog   171 DEQNCTLEIESYGYTTDDIEFYWLGGDNAVTGVERIELPQFSIMDHKLVSKNVVFATGSYPRLSL 235

  Fly   256 VFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPV 320
            .|.|:|.:||.:..||:||.||.::||:||||..:|..|||.||:|::||:.|.||..:::||.:
 Frog   236 SFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300

  Fly   321 SYVKAIDVWMSSCSVFVFLSLMEFAVVNNFM---GP-----VATKAMKGYSDE------------ 365
            .||||||:::..|.|||||:|:|:|.||...   ||     :|.|:.|...|.
 Frog   301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQMQKKLAEKSAKSNKDHSKFESNRVDAHG 365

  Fly   366 --------------------NISDLDDL-----KSALQHHRESII------------EPQYDTFC 393
                                ::||..:.     .|.:|:.::|..            .|...|..
 Frog   366 NILLTTLEIHNEVTGNEITTSVSDARNSATSFDNSGIQYRKQSTARDSLGRRTADRNHPPKKTHL 430

  Fly   394 HGHATAI-----------YIDKFSRFFFPFSFFILNIVYWTTFL 426
            ...::.:           .||::||..||.:|.:.|::||..::
 Frog   431 RRRSSQLKIKIPDLTDVNAIDRWSRIVFPITFSLFNLIYWLYYI 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	60/187 (32%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	44/85 (52%)
		TM1 helix	265..288	CDD:349851	12/22 (55%)
		TM2 helix	292..316	CDD:349851	11/23 (48%)
		TM3 helix	324..350	CDD:349851	15/25 (60%)
gabrb3	NP_001096164.1	LIC	11..473	CDD:273305	134/431 (31%)