DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prd1 and plekhm2

DIOPT Version :9

Sequence 1:	NP_650115.1	Gene:	prd1 / 41425	FlyBaseID:	FBgn0037949	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001124255.1	Gene:	plekhm2 / 564823	ZFINID:	ZDB-GENE-081022-169	Length:	994	Species:	Danio rerio

Alignment Length:	1077	Identity:	201/1077 - (18%)
Similarity:	349/1077 - (32%)	Gaps:	366/1077 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 YYSEPNIGDADSPKVKSVWNKEKKPKSSCLKKTKLH-----TNVILEQDLNGRVKKFNVHDIKHQ 359
            ||...|:.|.:          |:.|.|..|   .||     |:..||.|             ...
Zfish   169 YYKPQNLLDFE----------ERLPSSDSL---SLHSFTSLTSTNLEWD-------------DSA 207

  Fly   360 LLDNSSKMIFGSLKSIF-TMPL----------PERGVPEGSEDLQAVV-ECVPELEQTPEHKSRP 412
            :..:|....||.:..:. ::|.          |..|......|.|.|| :||.........::..
Zfish   208 IAPSSEDYDFGDIFPVLQSLPSADWEEGDLTDPVSGPRSSGSDPQTVVSDCVVVKASAGTIRTTS 272

  Fly   413 AAESPPLRAKPFLSKS-LDGSKQAQPVKKFVHNVDEQLRHKNEDDGASSTEASPMESKQSLMLHR 476
            .:.||..|..||...| .:.|....|    ||..........||...:|||.      :.:.:.|
Zfish   273 LSRSPTFRQNPFTEDSDTNTSADVTP----VHIASRHTSTTGEDAEITSTEL------EVIRMAR 327

  Fly   477 QEEFDKETVPMGSAQGEFRSKFIINCESTVFEHTGVSYETGD----LQSELSSGIQHTSVAS--- 534
            :.:..|:....||:         ::.|..|     :|.|..|    :..|....:.|.:|.|
Zfish   328 RRKPGKKRRGRGSS---------VSSEQNV-----ISPEVTDECLQIVVERDVTVNHITVDSRVP 378

  Fly   535 LLEQNTPIAEPAASQIKKSFLDAPIAKTFSNFFRSFKDSTPVAKDEQAVT--DNYFASKIAKPQQ 597
            |...::..:||..:..::...:.|              .|.:...|...|  ||     :.:|.:
Zfish   379 LERADSTASEPLRNGRREGEEEEP--------------ETGLRLPEMTDTSMDN-----VGQPLR 424

  Fly   598 QAPAAGKLQRNFSSSTISEPSSNTNTSSNHQIAMNPQLGNAERQSRHLPSPLKKRGQ-PLQPPRY 661
            :  ...:|..:..:...:|.....:....:|.......|...      |.|.....| ||.|..:
Zfish   425 E--VMDRLNGSLDAEDGAEEICTAHDGPPNQQPFREDAGGEP------PDPSDGFLQAPLPPADF 481

  Fly   662 Y--DQQHPHQSRSLHSPSAYLAAGRGGPGGSGRDSKSTILSEEFDDILTITTTDTTNARSMDSDL 724
            |  ..|.|..:.|        ..||....|.|......:.:|:..:
Zfish   482 YCFTSQSPDPAAS--------GGGRHDSAGHGEPQDVPVSNEDEGE------------------- 519

  Fly   725 VIVDYTDVDYAHLLKPPAPAAKTSLINRFLRNVTQKKIMETSIRKNNFFADKLRTEQRHAGSDLY 789
                 .:.:.|...:.|:.|.:||          :||:.:|.      ..|:..|:..||..
Zfish   520 -----AEAEAAAAGQDPSIAIETS----------EKKLSQTE------EDDEDATQSSHAAE--- 560

  Fly   790 VKGARPKNYELIDDLNAEIAMEIEMCGTNSPRRELAISLDNDFQGNLSNFELGIGEISIDVFKGK 854
                                                ..:||:.          :..:.|.||
Zfish   561 ------------------------------------FKVDNNH----------LLLLMIHVF--- 576

  Fly   855 SLFNLKQSNEQLMKAFKLYTGYNVDGIMTPVLVLLTDKTLYVVNMEG--NSLCVKFVLAYKDLDV 917
                 :::.|||.|..::.||: ::|.:.|:.:||||..:|::....  ....|:..::|.:||.
Zfish   577 -----RENEEQLFKMVRMSTGH-MEGDLQPLYLLLTDCYIYLLRKGAAEKPYSVEEAVSYNELDY 635

  Fly   918 ILMGPFGNTVLLSNSNRDMQQVLLAGG----------------------PYPAGSLVANLELCAR 960
            |.:|....|:.|..:||..|.:|....                      |||:
Zfish   636 ISVGLHQQTITLVCTNRRRQFLLDTADSSLTDWFLTVLKEAWENGCREPPYPS------------ 688

  Fly   961 RSGSTLPAVGQLTLEHLAPLQAFVRANSCVGVAEHWM-LYAVVNVPAGGSMRVESPSELLG---- 1020
                   .:...|:|.|| |..||...:...::|..: ||::|:......:.|.||:...|
Zfish   689 -------ILTDATMEKLA-LSKFVCQETHCEMSEMKIRLYSLVHWEDPMDVTVASPTSPSGSRAS 745

  Fly  1021 -PSMKGFLMHRRLRQTISTSAANRIFWQPGYFLLKAGVLYMFNDSTQRLP--SWAMALAECQGAR 1082
             .:.:|.|::|     ..:|...:..|:..|.:|..|:||.:.:.|...|  |..|....|.|.|
Zfish   746 SSTKEGPLLYR-----AGSSYLGKEVWKSCYLVLSNGILYQYAERTDVTPLMSVTMGGGHCGGCR 805

  Fly  1083 RTVKSERPHCFEITL-KGEVLQMAAPDEYVASEWLQALLQSAS-GLVVQ-EEKHKTLGCTLIVTD 1144
            |:..:|:||.|::.| :.:.|:::|.:|...::|:..|.||.| |::.| ......:.|.|::||
Zfish   806 RSNSTEKPHTFQVILTEHQPLELSAENELEMADWMLLLCQSVSKGIIPQGVAPAPCIPCCLVLTD 870

  Fly  1145 NHLITLREDFSAPLRKISQQADNNAAVQGNKETMLEEDMLSVFETSSLMGSTISTPTRGTQHSYS 1209
            ..|:|..:|.
Zfish   871 RKLLTCHQDC------------------------------------------------------- 880

  Fly  1210 SLSSTPTKQTNEDAAPKETVASPEKSQRMTSVYGKNSGLAILTCADIKEMTGIKITSRSETWWCI 1274
                                        .||.:....|      ||:.::|.:.:....|  :|:
Zfish   881 ----------------------------QTSFFRSLGG------ADLNDVTAVCLEDDKE--YCV 909

  Fly  1275 LEFSCQEAPLENQDDLVIFFASSMEMQRFLRLLEQLW 1311
            :||:  |...:.....|::|:...|..|.:..|.|.|
Zfish   910 IEFA--EDRAQFLPPWVLYFSGCKERDRLIAELSQAW 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prd1	NP_650115.1	PH	1021..1119	CDD:278594	27/100 (27%)
prd1	NP_650115.1	PH_SKIP	1022..1126	CDD:270119	31/107 (29%)
plekhm2	NP_001124255.1	RUN	44..156	CDD:295434
		PH_SKIP	748..850	CDD:270119	31/106 (29%)
		PH	748..848	CDD:278594	30/104 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto40702
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46556
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11261
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	4.090