Protein Alignment prd1 and PLEKHM2

DIOPT Version :9

• Sequence 1: NP_650115.1
• Gene: prd1 / 41425
• FlyBaseID: FBgn0037949
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_016856246.1
• Gene: PLEKHM2 / 23207
• HGNCID: 29131
• Length: 1032
• Species: Homo sapiens
• Alignment Length: 1071
• Identity: 215/1071 - (20%)
• Similarity: 360/1071 - (33%)
• Gaps: 343/1071 - (32%)

  Fly   362 DNSSKMIFGSLKSIFTMPLPERGVPEGSEDLQ--AVVECVPELEQT-------------PEH--- 408
            |:.|...|.|:.|. .:...:..:...|||..  .|...||.:..|             |..
Human   203 DSLSLNSFNSVTST-NLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRSTAS 266

  Fly   409 ---KSRPAAESPPLRAKPFLSKSLD--GSKQAQPVKKFVHNVD---EQLRHKNEDDGASSTEASP 465
               .|:.:..||..|..||..:..:  .|....|    ||...   |:.:..:..|..:..|...
Human   267 DLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTP----VHTTSQEKEEAQALDPPDACTELEVIR 327

  Fly   466 MESKQSLMLHRQEEFDKETVPMGSA--------QGEFRSKFIINCESTVFEHTGVSYETGDLQSE 522
            :..|:.:...::...|:|..|:..|        ||:..|:   |...::    |.......|.|.
Human   328 VTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSR---NGSPSL----GRDSPDTMLASP 385

  Fly   523 LSSGIQHTSVASLLEQNTP-IAEPAASQIKKSFLDAPIAKTFSNF----------------FRSF 570
            ...|...:|.....|::.| :..|.........|..|::|.....                .:||
Human   386 QEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQLDPSTWCSRAEPPDQSF 450

  Fly   571 KDSTP-VAKDEQAVTDNYFASKIAKPQQQAPAAGKLQRNFSSSTISEPSSNTNTSSNHQIAMNPQ 634
            :..:| .|.:...:.|  |:..::.|.           :|...|:..||:.|:...:|.
Human   451 RTGSPGDAPERPPLCD--FSEGLSAPM-----------DFYRFTVESPSTVTSGGGHHD------ 496

  Fly   635 LGNAERQSRHLPSPLKKRGQPLQPPRYYDQQHPHQSRSLHSPSAYLAAGRGGPGGSGRDSKSTIL 699
                       |:.|   |||                 ||.||:..|||:...||.|.......|
Human   497 -----------PAGL---GQP-----------------LHVPSSPEAAGQEEEGGGGEGQTPRPL 530

  Fly   700 SEEFDDILTITTTDTT-NARSMDSDLVIVDYTDVDYAHLLKPPAPAAKTSLINRFLRNVTQKKIM 763
            .            ||| .|:.:::.|.:|....|      ..|.|.             ||:.:.
Human   531 E------------DTTREAQELEAQLSLVREGPV------SEPEPG-------------TQEVLC 564

  Fly   764 ETSIRKNNFFADKLRTEQRHAGSDLYVKGARPKNYELIDDLNAEIAMEIEMCGTNSPRRELAISL 828
            :..           |.:.....|.....|        :|:            |..|| .|:..|
Human   565 QLK-----------RDQPSPCLSSAEDSG--------VDE------------GQGSP-SEMVHS- 596

  Fly   829 DNDFQGNLSNFELGIGEISIDVFKGKSLFNLKQSNEQLMKAFKLYTGYNVDGIMTPVLVLLTDKT 893
             ::|:.:.::..|    :.|.||        :::.|||.|..::.||: ::|.:..:.|||||..
Human   597 -SEFRVDNNHLLL----LMIHVF--------RENEEQLFKMIRMSTGH-MEGNLQLLYVLLTDCY 647

  Fly   894 LYVVNMEGNS--LCVKFVLAYKDLDVILMGPFGNTVLLSNSNRDMQQVLLAGGPYPAGSLVANLE 956
            :|::......  ..|:..::|.:||.:.:|....||.|..:||..|.:|.......|...:|:|:
Human   648 VYLLRKGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLK 712

  Fly   957 LCARRSGSTLPAVGQL----TLEHLAPLQAFVRANSCVGVAEHWMLYAVVNVPAGGSMRVESPS- 1016
             .|...|...|....:    |:|.||..:...:.:.|...|        |.|...|.:..|.|:
Human   713 -SAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEASA--------VTVRFYGLVHWEDPTD 768

  Fly  1017 ELLGPS-----------MKGFLMHRRLRQTISTSAANRIFWQPGYFLLKAGVLYMFNDSTQRLP- 1069
            |.|||:           .|..::|.:    ..||...:..|:..:.:|..|:||.:.|.|..:|
Human   769 ESLGPTPCHCSPPEGTITKEGMLHYK----AGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPL 829

  Fly  1070 -SWAMALAECQGARRTVKSERPHCFEITLKGE-VLQMAAPDEYVASEWLQALLQSASGLVVQE-- 1130
             |..|...:|.|.||...::|||.|::.|... .|:::|..|...:||:|.|.|:.|..|:.:
Human   830 LSVNMGGEQCGGCRRANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGV 894

  Fly  1131 EKHKTLGCTLIVTDNHLITLREDFSAPLRKISQQADNNAAVQGNKETMLEEDMLSVFETSSLMGS 1195
            .....:.|.|::||:.|.|..||...                            |.|.
Human   895 APSPCIPCCLVLTDDRLFTCHEDCQT----------------------------SFFR------- 924

  Fly  1196 TISTPTRGTQHSYSSLSSTPTKQTNEDAAPKETVASPEKSQRMTSVYGKNSGLAILTCADIKEMT 1260
            ::.|...|   ..|::|:.|.|:
Human   925 SLGTAKLG---DISAVSTEPGKE------------------------------------------ 944

  Fly  1261 GIKITSRSETWWCILEFSCQEAPLENQDD------LVIFFASSMEMQRFLRLLEQLWQSKNNDLF 1319
                       :|:||||        ||.      .||:.:.:.|:.|.|..|...|::......
Human   945 -----------YCVLEFS--------QDSQQLLPPWVIYLSCTSELDRLLSALNSGWKTIYQVDL 990

  Fly  1320 PITILDDGDSLAEQYNKLYMDT----NRAWE 1346
            |.|.:.:..:     .|.:.|.    :.||:
Human   991 PHTAIQEASN-----KKKFEDALSLIHSAWQ 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prd1	NP_650115.1	PH	1021..1119	CDD:278594	30/111 (27%)
		PH_SKIP	1022..1126	CDD:270119	32/117 (27%)
PLEKHM2	XP_016856246.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11302
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto90383
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46556
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11261
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	5.090