DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prd1 and AgaP_AGAP001907

DIOPT Version :9

Sequence 1:	NP_650115.1	Gene:	prd1 / 41425	FlyBaseID:	FBgn0037949	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_321158.5	Gene:	AgaP_AGAP001907 / 1281220	VectorBaseID:	AGAP001907	Length:	1668	Species:	Anopheles gambiae

Alignment Length:	1718	Identity:	699/1718 - (40%)
Similarity:	884/1718 - (51%)	Gaps:	493/1718 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KMSSSLNSSTMEDTTPSDSGVQLLDSENS---DVMVESICSYEENVRPMPLP------------- 65
            |||||: :|.::|||||||||||||||:|   :.|:.|...:|.:..|.|.|
Mosquito    61 KMSSSV-ASILDDTTPSDSGVQLLDSESSGLNESMISSAGGFEFDGGPTPPPPLPPAAASGAATP 124

  Fly    66 ----------------------------------------------------------------- 65

Mosquito   125 FGEEGKNNNNNYNSYHDRPVAEMEVEAAEEEEEDDVAVGGPAGGDDLDEAGEAKLAADQEIGEGI 189

  Fly    66 LVDPNSNVTAAPDESMTISECSTFDTTEKIVYRRKVHKASSASKTPKKRVSFHEDILKNTRTDNI 130
            .::|..:.:..|||.:: |.||||| :|.|||||:: |.:..||||||||||||||||||:||||
Mosquito   190 EIEPGMSTSQVPDELIS-STCSTFD-SENIVYRRRI-KKTPMSKTPKKRVSFHEDILKNTKTDNI 251

  Fly   131 HIEHGFITYKNGRKLAFANSAGVAG-APGRYSWCPDRERPEGPNELSAAGREDDGEEATGGGG-- 192
            ||||||||||.|       .||... |.||||||                .|||    |||.|
Mosquito   252 HIEHGFITYKTG-------GAGKKNVAKGRYSWC----------------SEDD----TGGAGYD 289

  Fly   193 -----ARRKRHLVYRNACSDVLDY--DNIFDT--DEAPGLHYDTSGVFEYGP--ATQKQEE---- 242
                 |...|..||||||||||||  .::|:.  ||...:.||.||||||||  .|.|..:
Mosquito   290 YGDEEAHEGRQYVYRNACSDVLDYGKTDVFENVEDERNYVKYDNSGVFEYGPPERTTKVSDLIGG 354

  Fly   243 QPQLYKCVCSSSNSSLDSDEQDKNSNANCKQYEQAKSSSCDCIGMS--------------NANNN 293
            ...||||.||.|||||||.|   ..|.....|.||||:||:|||.:              |.|||
Mosquito   355 GKALYKCGCSDSNSSLDSGE---GGNTQTTNYRQAKSNSCECIGSNGGGGATGRRGKHGGNNNNN 416

  Fly   294 LIGDNCYYSEPNI-----------------GDADSPKVKSVWNKEKKPKSSCLKKTK---LHTNV 338
            :|.||||||||:|                 |.||...|||||:||||||||||||||   :.|||
Mosquito   417 IISDNCYYSEPSIEHLDEFNGNVTGGGGEGGGADEQFVKSVWSKEKKPKSSCLKKTKRNSIFTNV 481

  Fly   339 IL-EQDLNGRVKKFNVHDIKHQLLDNSSKMIFGSLKSIFTMPLPERGVPEGSEDLQAVVECVPEL 402
            :: |.||:.:|||||||. :..::|| |:|||||||.||.:.|||||||||||||.:|.||:||:
Mosquito   482 VVPEYDLSRKVKKFNVHQ-RLSVIDN-SRMIFGSLKDIFGIALPERGVPEGSEDLSSVRECIPEV 544

  Fly   403 EQTPEHKSRPAAESPPLRAKP--FLSKSLDGS--------KQAQPVKKFVHNVDEQLRHKNEDD- 456
                 |......:...|..||  ||||||||.        ..|...||:|||||||||.||::|
Mosquito   545 -----HDDATLEDDFTLVQKPKSFLSKSLDGGFLSRAGGRPNAGQQKKYVHNVDEQLRRKNDEDL 604

  Fly   457 ------GASSTEASPMESKQSLMLHRQEEFDKETVPMGS---------------AQGEFRSKFII 500
                  .:...|..|.|:........:.|..:|.|...:               |...:|:||||
Mosquito   605 YAPSRKNSVEDELPPAETDTDGGNCGEREQSEEDVTFSTPDSVSQTALGAACVGATAAYRNKFII 669

  Fly   501 NCESTVFEHTGVSY--ETGDLQSELSSGIQHTSVASLLEQNTPIAEPAASQIKKSFL-DAPIAKT 562
            |.||||:|||||||  |.|..::.|..           |:..|:.|..:.    ||: :..|.|.
Mosquito   670 NGESTVYEHTGVSYCFEDGQDKTPLEE-----------EKELPVGETTSG----SFIGNTQIKKK 719

  Fly   563 FSNFFRSFKDSTPVAKDEQAVTDNYFASKIAKPQQQAP--------------AAGKLQRNFSSST 613
            .|..|:..               |..:|:.:.|...||              ||.:|:|...||.
Mosquito   720 LSTIFQKM---------------NVISSQASTPNPTAPRPGGDGDAERGGDEAAQRLRRESGSSA 769

  Fly   614 ISEP-------------SSNTNTSSNHQIAMNPQLGNAERQ-------------------SRHLP 646
            :..|             |:.::.||.|.   .||||..||:                   :|||.
Mosquito   770 LPSPPSPKQSEKVLMESSTISSCSSEHS---EPQLGAVERKQSGSGSPRASAASGSASKANRHLS 831

  Fly   647 SPLKKRG------QPLQPPRYYDQQHPHQSRSLHSPSAYLAAGRGGPGGSGRDSKSTI---LSEE 702
            ||||.|.      :..:|.|.             ||..:    ..|.....|:....|   |:.|
Mosquito   832 SPLKNRSLTTTRMEASRPSRM-------------SPDLF----NLGVVPPTRNLSHIIDPQLAVE 879

  Fly   703 FDDILTI-TTTDTTNARS-------------------MDSDLVIVDY---TDVDYAHLLKPPAP- 743
            |:||||: |||.|||..:                   ::.|||||||   :....|..|.|..|
Mosquito   880 FEDILTVTTTTHTTNTTTESLIESVDQHQQVDKKPSLIEDDLVIVDYPSSSGASSAAALTPVTPQ 944

  Fly   744 ------------------------------------AAKTSLINRFLRNVTQKKIMETSIRKNNF 772
                                                |:|:|||||||||||||||:|.:|::|.|
Mosquito   945 SEELFARQTNRTPYQQQQQRHRHNPMTSSTTSSASTASKSSLINRFLRNVTQKKILEATIKQNPF 1009

  Fly   773 FADKLRTEQRHAGSDLYVKG-ARPKNYELIDDLNAEIAMEIEMCGTNSPRRELAISLD----ND- 831
            |..||..| |....:|..:| |||.|.||::|||||||||||:..:       |..||    ||
Mosquito  1010 FQSKLNGE-RKLFENLCPRGPARPINRELVEDLNAEIAMEIELSSS-------ACQLDRIQLNDT 1066

  Fly   832 ------------------FQGNLSNFELGIGEISIDVFK-GKSLFNLKQSNEQLMKAFKLYTGYN 877
                              |.|.    .:|:||:.:::|. |..|...:..:|.|||.|||:.||:
Mosquito  1067 YAQSGAESASPFALGGVKFDGG----GIGVGELPVELFSAGPRLSIYRNDSEVLMKVFKLFNGYS 1127

  Fly   878 VDGIMTPVLVLLTDKTLYVVNMEGNSLCVKFVLAYKDLDVILMGPFGNTVLLSNSNRDMQQVLLA 942
            .:|.||||||.|||:||||.:...|.||.||||.|.:|||||:||:|||||||||.|||||||||
Mosquito  1128 REGYMTPVLVFLTDRTLYVTDQVRNKLCNKFVLPYAELDVILVGPYGNTVLLSNSARDMQQVLLA 1192

  Fly   943 GGPYPAGSLVANLELCARRSGSTLPAVGQLTLEHLAPLQAFVRANSCVGVAEHWMLYAVVNVPAG 1007
            ||||||..||::|||||||.||.|||||||||:||||||||||.:|.|...:.|..|||||||||
Mosquito  1193 GGPYPAEGLVSSLELCARRGGSVLPAVGQLTLDHLAPLQAFVRDHSSVSREDSWKYYAVVNVPAG 1257

  Fly  1008 GSMRVESPSELLGPSMKGFLMHRRLRQTISTSAANRI-FWQPGYFLLKAGVLYMFNDSTQRLPSW 1071
            .....|:|   |||.:||.|||||:      |.|..: .|..|||||||||||:|.|::|:||:|
Mosquito  1258 TLGSEEAP---LGPHIKGPLMHRRM------SHAGFVDNWSAGYFLLKAGVLYLFADASQKLPTW 1313

  Fly  1072 AMALAECQGARRTVKSERPHCFEITLKGEVLQMAAPDEYVASEWLQALLQSASGLVVQEEKHKTL 1136
            |:||||||||||:|.|.||:|||:.|:...||:|||||||||:|||||:|:||||...:|:.:||
Mosquito  1314 AVALAECQGARRSVNSGRPYCFELLLRTGALQLAAPDEYVASDWLQALVQAASGLFEMQERRRTL 1378

  Fly  1137 GCTLIVTDNHLITLREDFSAPLRK---------ISQ-QADNNAAVQ-------GNKETM------ 1178
            |||||:|.|||:|||||||||||:         ||. .:.:||::|       .:||.:
Mosquito  1379 GCTLIMTSNHLLTLREDFSAPLRRNTSYSTVGEISNPSSTSNASMQLQLCLSSPSKENINPNATR 1443

  Fly  1179 -------LEEDMLSVFETSSLMGSTISTPTR---------GTQHSYSSLSSTPTK---------- 1217
                   .....|..|...|.:.|..|||||         ..:.|.:|.:||||:
Mosquito  1444 RKISNVSSSNGGLDNFSEISSIRSNCSTPTRTNVAGQLISADRRSNASSTSTPTRGSAMQQQQQQ 1508

  Fly  1218 QTNEDAAPKETV--------------------ASPEKS-QRMTSVYGKNSGLAILTCADIKEMTG 1261
            |...:|:|..::                    ::.||| ..|:|.||||||:.:||||.|.||:.
Mosquito  1509 QQLLNASPARSLPRSGALATSGPPSLVDFFAGSTEEKSYTNMSSFYGKNSGVEVLTCASIDEMSA 1573

  Fly  1262 IKITSRSETWWCILEFSCQEAPLENQDDLVIFFASSMEMQRFLRLLEQLWQSKNNDLFPITILDD 1326
            :||.:.|..|||||||.|||. .||.||||:||::|.|.:|||.:||.:|.:|.::.||.:|:..
Mosquito  1574 VKIPAISSNWWCILEFECQEV-RENSDDLVVFFSTSAEQERFLSMLESIWHTKKSEAFPASIISS 1637

  Fly  1327 GDSLAEQYNKLYMDTNRAWEPLLSAALG 1354
            .|::.:..:||:::.||:||||||||||
Mosquito  1638 DDAVYDHCSKLFLEINRSWEPLLSAALG 1665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prd1	NP_650115.1	PH	1021..1119	CDD:278594	61/98 (62%)
prd1	NP_650115.1	PH_SKIP	1022..1126	CDD:270119	65/104 (63%)
AgaP_AGAP001907	XP_321158.5	PH	1268..1366	CDD:278594	64/103 (62%)
AgaP_AGAP001907	XP_321158.5	PH-like	1271..1368	CDD:302622	65/102 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	648	1.000	Domainoid score	I559
eggNOG	1	0.900	-	-		E1_29X4V
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34839
Inparanoid	1	1.050	949	1.000	Inparanoid score	I1019
OMA	1	1.010	-	-		QHG26458
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0020285
OrthoInspector	1	1.000	-	-		oto109180
Panther	1	1.100	-	-	LDO	PTHR46556
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X15951
TreeFam	1	0.960	-	-
	12	11.930