DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)neo38 and Spps

DIOPT Version :9

Sequence 1:	NP_001262485.1	Gene:	l(3)neo38 / 41423	FlyBaseID:	FBgn0265276	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	121/487 - (24%)
Similarity:	174/487 - (35%)	Gaps:	143/487 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AQTPGAFGTP-PAAAANAAAAAAAAGTDNHVQRYQTNGN----HFNQNVPNVSAANNMQYGQNIS 82
            |.||...|.| |....|..|..        :|.....|.    |.||..||:.|  |.|  |.::
  Fly   467 APTPAPAGVPTPMQMPNLQALP--------IQNIPGLGQVQIIHANQLPPNLPA--NFQ--QVLT 519

  Fly    83 -IPYSQPQGDLNFLNAAAAADHKGKIH--PKIERDREEVLNQQILQNVNQSWQTL---------A 135
             :|.|.||           ...:|::.  ||.|......:...|.|....::..:         |
  Fly   520 QLPMSHPQ-----------VQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPA 573

  Fly   136 NTANTVD-----------YSSHLLSATLPISIQHFLKYSETIKKESTGDV---------LKNGTN 180
            :|.||..           .|:.|.|.::|.|||......:.....:|...         .::..|
  Fly   574 STPNTASPQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVN 638

  Fly   181 LASLALGGVALTPSNNGANGGHHNGLVGMDHGGHMTNM-TDANGAALTNGASNGVNGNANGTVTN 244
            ..:.:...:.:.|:                 ||.:.:: |.|.||..:..::|    .:..|:|.
  Fly   639 AVTTSSTQITIAPT-----------------GGQVVSVTTQARGATASIRSTN----TSTTTITT 682

  Fly   245 GGAGAVS---SSGSVGTTNASGGTGTASGKKTKKKKPPKEKKPRPKPGEIRETKALDGSTLYC-C 305
            .....::   |..|||.....||.|||:|          |.|||.|             .:.| |
  Fly   683 PSQSHLNMNISVASVGGAATGGGGGTATG----------EPKPRLK-------------RVACTC 724

  Fly   306 PECQMAYPDRSLIEQHVISHAVERRFVCDI--CNAALKRKDHLTRHKLSHIPDRPHVCN--ICMK 366
            |.|...       |:|   ...:|:.:|.|  |:....:..||..|...|..:||.||:  .|.|
  Fly   725 PNCTDG-------EKH---SDKKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGK 779

  Fly   367 SFKRKEQLTLHIVIHSGEKKHVCIECGKGFYRKDHLRKHTRSHIARR---------VKSEVSAQN 422
            .|.|.::|..|...|:|||:..|.||.|.|.|.|||.||.::|...|         :|.|....|
  Fly   780 RFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIKQETKGGN 844

  Fly   423 -------VNG----SAGGGGGGGGGNSAQSNA 443
                   |||    ...|||....|:.|.|.|
  Fly   845 APKSISTVNGIVTIEIPGGGSAAAGSGASSVA 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)neo38	NP_001262485.1	C2H2 Zn finger	305..325	CDD:275368	5/19 (26%)
		zf-C2H2_8	306..391	CDD:292531	27/88 (31%)
		C2H2 Zn finger	333..353	CDD:275368	6/21 (29%)
		zf-H2C2_2	345..370	CDD:290200	11/26 (42%)
		C2H2 Zn finger	361..381	CDD:275368	7/21 (33%)
		zf-H2C2_2	374..398	CDD:290200	11/23 (48%)
		C2H2 Zn finger	389..409	CDD:275368	11/19 (58%)
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	38/111 (34%)
		C2H2 Zn finger	742..764	CDD:275368	6/21 (29%)
		zf-H2C2_2	756..783	CDD:290200	11/26 (42%)
		C2H2 Zn finger	772..794	CDD:275368	7/21 (33%)
		zf-H2C2_2	786..809	CDD:290200	10/22 (45%)
		zf-C2H2	800..822	CDD:278523	11/21 (52%)
		C2H2 Zn finger	802..822	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010