DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6923 and PJA2

DIOPT Version :9

Sequence 1:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_055634.3	Gene:	PJA2 / 9867	HGNCID:	17481	Length:	708	Species:	Homo sapiens

Alignment Length:	1149	Identity:	198/1149 - (17%)
Similarity:	306/1149 - (26%)	Gaps:	509/1149 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EPLTMEPESDNDGDAVVASVSGTW--PAGAIE-----------------------EHAMDSTAVV 197
            ||..|:.||   |.||       |  |||..:                       |.::......
Human     8 EPAAMDQES---GKAV-------WPKPAGGYQTITGRRYGRRHAYVSFKPCMTRHERSLGRAGDD 62

  Fly   198 YEVPSSSLQLSNSSFETAPSAVNAYDDVTSS--------ASDTEHGQFAHTRTTNTTTTTSAVQA 254
            |||    |:|.:...|.: |..:..|.|.||        .|:||...........|.::.|.|..
Human    63 YEV----LELDDVPKENS-SGSSPLDQVDSSLPSEPIFEKSETEIPTCGSALNQTTESSQSFVAV 122

  Fly   255 HKKKASR-----SNNASNTSSRAVDTDATPSTSAQSRKRQMSQFSYRKSRVLEPENESSDDGWDL 314
            |..:..|     |.|..|.|.......|..::|.|:....:...||      :|:.:..:|...|
Human   123 HHSEEGRDTLGSSTNLHNHSEGEYIPGACSASSVQNGIALVHTDSY------DPDGKHGEDNDHL 181

  Fly   315 RVHNPVPPIEPTVTIIRGSRGSDEAEIGHTDHNYYNSRC-AVAG-APPDSTYIRSASCSTATHTT 377
            ::         :..::.|||..:  .:|:|.....|... |..| :||    :.|.:|..... .
Human   182 QL---------SAEVVEGSRYQE--SLGNTVFELENREAEAYTGLSPP----VPSFNCEVRDE-F 230

  Fly   378 RSVDYGSRIGRRSAATGSPSTSSDQEQEQQQRQQQEEIIHEERRHQQSPGQPMHSMYGVPGESRM 442
            ..:|   .:....::.|.........||.|:..|.|.:..:::.:.....|..||
Human   231 EELD---SVPLVKSSAGDTEFVHQNSQEIQRSSQDEMVSTKQQNNTSQERQTEHS---------- 282

  Fly   443 SWSRARPSDDSVPPRKHARMELPGRSRSKLSSTNFNSFYPGRRGHRTFAEQGNSSGQHHVRFPPS 507
                  |.|.:..|                             ||....:..|...::|     .
Human   283 ------PEDAACGP-----------------------------GHICSEQNTNDREKNH-----G 307

  Fly   508 STPNSNGPCVITYVGRPRDSQPAADLNLPSTSTGRRGSHETRADSVVLTAPDLQLDDWSSDDDDD 572
            |:|..        |.||:..:..:...:...:...|  ||.:..||......|::::..|||
Human   308 SSPEQ--------VVRPKVRKLISSSQVDQETGFNR--HEAKQRSVQRWREALEVEESGSDD--- 359

  Fly   573 DVVFVHSTREPILSIDLTSDDDGLANDTQLQRDRDRGRERERERARDREPYRNDTQPNPEDPNED 637
                        |.|..                               |.|..:
Human   360 ------------LLIKC-------------------------------EEYDGE----------- 370

  Fly   638 RRTMYDCAYTF-PYARRTDRRTEANNEGTSAFAFYSGALADRAAISDHNYSYELDQLMDPGPGNF 701
                :||.:.. ||:|...:|...||:.||.    |||.|.|         .|:|.....|.|::
Human   371 ----HDCMFLDPPYSRVITQRETENNQMTSE----SGATAGR---------QEVDNTFWNGCGDY 418

  Fly   702 YPPRCSNMDPQRYFLPINESSMWMPGHPAPPPPPPPMPPILLPDNSSTEAYLRHQQRNLTSTPSS 766
            |         |.|.                            .|..|:|........:|....|.
Human   419 Y---------QLYD----------------------------KDEDSSECSDGEWSASLPHRFSG 446

  Fly   767 SSSEQTSTQQSRHRRSSPANVYHRYHPYYYAITTLPTVVESDYPPSLQPHPHPHPHFQPSQGGSS 831
            :..:|:|:.:|..                    |||...|::            |..|....|..
Human   447 TEKDQSSSDESWE--------------------TLPGKDENE------------PELQSDSSGPE 479

  Fly   832 RSSLSGALNAAAVAATAAAVQAQTFSDLLSQAHNEGRAAALEGNRTPPHTMVHAQHQQRQSINPP 896
            ..:...:|                         .||...:||....|...............|.|
Human   480 EENQELSL-------------------------QEGEQTSLEEGEIPWLQYNEVNESSSDEGNEP 519

  Fly   897 APGVASNANLAAAVSPPPPLEMYSGRSTIPHCGSPPFSVRRSEAAYSNRQHYQPQPHQGHQAPQN 961
            |...|.            |..|..|.:.:....|
Human   520 ANEFAQ------------PAFMLDGNNNLEDDSS------------------------------- 541

  Fly   962 QMHAHIHPPHRASAIVATSLTPAPPYPVHQNLWYRQQSMQEMHRRHMTPTPIDLSSNAPLLTSTL 1026
                                       |.::|                  .:|.|         |
Human   542 ---------------------------VSEDL------------------DVDWS---------L 552

  Fly  1027 RNGYLHSICSCVHARNGPVSSLDPAYYPPYDAAPAAAAPPPSPQQQSPATSGSGNSSVAAQASMR 1091
            .:|:...: ....|    :|.:||.:                                     :.
Human   553 FDGFADGL-GVAEA----ISYVDPQF-------------------------------------LT 575

  Fly  1092 HLQLQPQQQPQAQQSPPVMQHMQRQRAIHHHMFHHHYSPLHLEIGLAPLSLGSRILIAPSRPNRG 1156
            ::.|:.:          :.|.|:...|             |||      ||...:.:|    |..
Human   576 YMALEER----------LAQAMETALA-------------HLE------SLAVDVEVA----NPP 607

  Fly  1157 ATLETIERNTLPHKYRRVRRPSET----DEDA----EKCAICLNLFEIENEVRRLPCMHLFHTDC 1213
            |:.|:|:  .||          ||    |..|    :.|.||.:.:..::....|||.|.||..|
Human   608 ASKESID--GLP----------ETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPC 660

  Fly  1214 VDQWLVTNKHCPICRVDIETHMP----NDALPPSSSGVPDAANS 1253
            |..||..:..||:||    .|.|    ..:..|||...|||..|
Human   661 VSIWLQKSGTCPVCR----RHFPPAVIEASAAPSSEPDPDAPPS 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448	15/42 (36%)
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367	15/40 (38%)
PJA2	NP_055634.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		12/32 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..90		12/41 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..317		20/130 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..495		18/126 (14%)
		Interaction with PRKAR1A, PRKAR2A and PRKAR2B. /evidence=ECO:0000269\|PubMed:21423175	531..708		58/346 (17%)
		zf-RING_2	634..675	CDD:290367	15/40 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..708		7/16 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1249953at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010