Protein Alignment CG6923 and Rnf111

DIOPT Version :10

• Sequence 1: NP_001262484.1
• Gene: CG6923 / 41420
• FlyBaseID: FBgn0037944
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_006511639.1
• Gene: Rnf111 / 93836
• MGIID: 1934919
• Length: 1097
• Species: Mus musculus
• Alignment Length: 1363
• Identity: 290/1363 - (21%)
• Similarity: 409/1363 - (30%)
• Gaps: 620/1363 - (45%)

  Fly     5 ENDQ--EELHHQPRVTLAYGSVATSSGGQE-----NHSQYAMYYNQQRDSEGYMLMTPFLSS-SQ 61
            :||.  .|....|..:|.:|...|.:..::     .|:|                  |.||: |:
Mouse   227 DNDSSLSECLSSPSSSLHFGGSDTVTSDEDKEVSVRHTQ------------------PVLSAKSR 273

  Fly    62 SHS-------HTRSPPTYTAMVEPRREESSGFEGLARRCDKCSSLDGL-CRCESMVASSSRYADS 118
            |||       .|.:.|..:.:::             |.|...|:|..: || :.:|.|||    |
Mouse   274 SHSARSHKWPRTEADPVPSLLMK-------------RPCFHGSALRRVTCR-KRLVKSSS----S 320

  Fly   119 TQNQSHSEAQFLEQPSSSTAAIANPPAVHSIPRPKRKKTEPL---------TMEPESDNDGDAVV 174
            .:.|...|...::                      |||.|.|         :....|:||..:..
Mouse   321 QRTQKQKERMLVQ----------------------RKKREALAQRKYALLSSSSSSSENDLSSDS 363

  Fly   175 ASVSGTWPAGAIEEHAMDSTAVVYEVPSSSLQLSNSSFETAPSAVNAYDDVTSSASDTEHGQFAH 239
            :|.|.|       :...|..|...|.||:         ..|||.....|.|...||.|.  |...
Mouse   364 SSSSST-------DGEEDLCASASENPSN---------PAAPSGSIDEDVVVIEASFTP--QVTA 410

  Fly   240 TRTTNTTTTTSAV------QAHKKKASRSNNASNTSSRAVDTDATPSTSAQSRKRQMSQFSYRKS 298
            ....|.|:|.|.|      ::::.:::..::.|:.|.         .:|:.:.:.|.|:...|.|
Mouse   411 NEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQ---------GSSSHTGRPQESRNRSRIS 466

  Fly   299 RVLEPENESSDDGWDLRVHNPVPPIEPTVTIIRGSRGSDEAEIGH----TDHNYYNSRCAVAGAP 359
            .|::|..:::.:..||.|....|.|.|| |..|....:..|.|.:    |.....::...||.:.
Mouse   467 TVIQPLRQNAAEVVDLTVDEDEPTIVPT-TSARMDSQTTSASINNSNPSTSEQASDTTSTVASSQ 530

  Fly   360 PDSTYIRSASCSTATHTTRSVDYGSRIG---RRSAATGSPSTSSDQEQEQQQRQQQEEIIHEERR 421
            |.     :.|.:.||.|:.|.. ||.:|   ||:|::..|.:.
Mouse   531 PS-----TVSETEATLTSNSAT-GSSVGDDVRRTASSAVPESG---------------------- 567

  Fly   422 HQQSPGQ-------PMHSMYGVPGESRMSWSRARPSDDSVPPRKHARMELPGRSRSKLSSTNFNS 479
               .|..       |.||..|  |.|:...:.|.|                       .|:.|.
Mouse   568 ---PPAMPRLPSCCPQHSPCG--GTSQSHHALAHP-----------------------HSSCFQ- 603

  Fly   480 FYPGRRGHRTFAEQGNSSGQHHVRFPPSSTPNSNGPCVITYVGRPRDSQPAADLNLP-------S 537
                :.||. |...     .||...|..:.|.|           |..|.||..:..|       :
Mouse   604 ----QHGHH-FQHH-----HHHHHTPHPAVPVS-----------PSFSDPACPVERPQVQAPCGA 647

  Fly   538 TSTGRRGSHETRADSVVLTAPDLQLDDWSSDDDDDDVVFVHSTREPILSIDLTSDDDGLANDTQL 602
            .|:.....|:.:|                                  |.:||::.
Mouse   648 NSSSGSSYHDQQA----------------------------------LPVDLSNS---------- 668

  Fly   603 QRDRDRGRERERERARDREPYRNDTQPNPEDPNEDRRTMYDCAYTFPYARRTDRRTEANNEGTSA 667
                                                            |.||  .......|.||
Mouse   669 ------------------------------------------------ALRT--HGSGGFHGASA 683

  Fly   668 FAFYSGALADRAAISDHNYSYELDQLMDPGPGNFYPPRCSNMDPQRYFLPINESSMWMPGHPAPP 732
            |.......:.|||:..|..:                  .:...|    |.|:.....|...|.|.
Mouse   684 FDPCCPVTSSRAAVFGHQAA------------------AAPTQP----LSIDGYGSSMVAQPQPQ 726

  Fly   733 PPPPP--------MPPILLPDNSSTEAYLRHQQRNLTSTPSSSSSEQTSTQQSRHRRSSPANVYH 789
            |||.|        |||   |..|.|.. |.||                            |:..|
Mouse   727 PPPQPSLSSCRHYMPP---PYASLTRP-LHHQ----------------------------ASACH 759

  Fly   790 RYHPYYYAITTLPTVVESDYPPSLQPHPH-----PHPHFQPSQGGSSRSSLSGALNAAAVAATAA 849
            ..|              .:.||..||.|.     |||
Mouse   760 HSH--------------GNAPPQTQPPPQVDYVIPHP---------------------------- 782

  Fly   850 AVQAQTFSDLLSQAHNEGRAAALEGNRTPPHTMVHAQHQQRQSINPPAPGVASNANLAAAVSPPP 914
                                             |||.|.|          ::|:| .:..|:|||
Mouse   783 ---------------------------------VHAFHSQ----------ISSHA-ASHPVAPPP 803

  Fly   915 PLEMYSGRSTIP-HCGSPPFSVRRSEAAYSNRQHYQPQPHQGHQAPQNQMHAHIHPPHRASAIVA 978
            |..:.|..:.|| |.  ||        |:....|:.|.|     ||..|   .:|
Mouse   804 PTHLGSTAAPIPQHL--PP--------AHQPISHHIPAP-----APSAQ---RLH---------- 840

  Fly   979 TSLTPAPPYPVHQNLWYRQQSMQEMHRRHMTPTPIDLSSNAPLLTSTLRNGYLHSICSCVHARNG 1043
                   |:.|.|.:        |:.||.|...|..|                  ...||..|
Mouse   841 -------PHEVMQRM--------EVQRRRMMQHPTGL------------------FVFCVSRR-- 870

  Fly  1044 PVSSLDPAYYPPYDAAPAAAAPPPSPQQQSPATSGSGNSSVAAQASMRHLQLQPQQQPQ------ 1102
                             |...|||.|.:..| ..|.|:.....|....|    |:|.|:
Mouse   871 -----------------AHERPPPHPHRMHP-NYGHGHHIHVPQTMSSH----PRQAPERTAWEL 913

  Fly  1103 --------AQQSPPVMQHMQRQRAIHHHMFHHHYSPL--HLEIGLAPL----------------S 1141
                    |..:|         .|:|.|:.|:|..|.  ||::|..||                .
Mouse   914 GIEAGVTAATYTP---------GALHPHLAHYHAPPRLHHLQLGALPLMVPDMAGYPHIRYISSG 969

  Fly  1142 LGSRILIAPSR---------------PNRGATLETIERNTLPHKYRRV------------RRPSE 1179
            |.......|.|               .||||:..||||.|.||||::|            ::..|
Mouse   970 LDGASFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKVTTDWFSQRKLHCKQDGE 1034

  Fly  1180 --TDEDA-EKCAICLNLFEIENEVRRLPCMHLFHTDCVDQWLVTNKHCPICRVDIETHMPNDA 1239
              |:||. |||.|||::.|...:|||||||||||..||||||:|||.|||||||||..:|:::
Mouse  1035 EGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIEAQLPSES 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6923	NP_001262484.1	HRD1	<1155..>1256	CDD:227568	54/100 (54%)
		RING-H2_RNF111-like	1185..1230	CDD:438137	32/44 (73%)
Rnf111	XP_006511639.1	RNF111_N	117..389	CDD:464629	47/235 (20%)
		Peptidase_S64	377..>524	CDD:369740	39/167 (23%)
		DUF5585	496..>627	CDD:465521	38/208 (18%)
		RING-H2_RNF111	1033..1093	CDD:438343	40/59 (68%)