DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6923 and RNF128

DIOPT Version :9

Sequence 1:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_919445.1	Gene:	RNF128 / 79589	HGNCID:	21153	Length:	428	Species:	Homo sapiens

Alignment Length:	418	Identity:	84/418 - (20%)
Similarity:	146/418 - (34%)	Gaps:	128/418 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   895 PPAPGVASN-----ANLAA-----AVSPPPP--------LEMYSGRS-TIPHCGSPPFSVRRSEA 940
            ||..||:..     :.|.|     |:||..|        ...|...| .:||.|     |.|:..
Human     4 PPGAGVSCRGGCGFSRLLAWCFLLALSPQAPGSRGAEAVWTAYLNVSWRVPHTG-----VNRTVW 63

  Fly   941 AYSNRQHYQPQPHQGHQAPQNQMHAHIHPPHRASAIVATSLTPAPPYPVHQNLWYRQQSMQEMHR 1005
            ..|....|      |..:|...:...:.||....|:.|.:                      .|.
Human    64 ELSEEGVY------GQDSPLEPVAGVLVPPDGPGALNACN----------------------PHT 100

  Fly  1006 RHMTPTPIDLSSNAPLLTSTLRNGYLHSICSCVHARNGPVSSLDPAYYPPYDAAPAAAAPPPSPQ 1070
            ....||         :..||::..:|..|     .|.|..:..|..:. .|:...:.|.....|
Human   101 NFTVPT---------VWGSTVQVSWLALI-----QRGGGCTFADKIHL-AYERGASGAVIFNFP- 149

  Fly  1071 QQSPATSGSGNSSVAAQASMRHLQLQPQQQPQA----------QQSPPVMQHMQRQRAI------ 1119
                   |:.|..:            |...|.|          .:...::|.:||...:
Human   150 -------GTRNEVI------------PMSHPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEV 195

  Fly  1120 --HHHMFHHHYSPLHLEIG---LAPLSLGSRILIAPSRPNRGATLETIERNTLPHKYRRV----- 1174
              .|..:.:|||...:.:.   :...::|..|..: :|..|.|..::.::..|....::.
Human   196 GKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYS-ARRLRNARAQSRKQRQLKADAKKAIGRLQ 259

  Fly  1175 -----RRPSETDEDAEKCAICLNLFEIENEVRRLPCMHLFHTDCVDQWLVTNKHCPICRVD---- 1230
                 :...|...|.:.||:|:.|::..:.||.|.|.|:||..|||.||:.::.||:|:.|
Human   260 LRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKA 324

  Fly  1231 --IETHMPNDALP---PSSSGVPDAANS 1253
              ||..:.:.::.   |.|:.:.::|:|
Human   325 LGIEVDVEDGSVSLQVPVSNEISNSASS 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448	18/42 (43%)
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367	18/40 (45%)
RNF128	NP_919445.1	PA_GRAIL_like	48..193	CDD:239037	35/212 (17%)
		RING-H2_RNF128_like	275..323	CDD:319716	20/47 (43%)
		RING-H2 finger (C3H2C3-type)	277..317	CDD:319716	18/39 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..428		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D442767at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920