DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6923 and PJA1

DIOPT Version :9

Sequence 1:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_001369704.1	Gene:	PJA1 / 64219	HGNCID:	16648	Length:	643	Species:	Homo sapiens

Alignment Length:	655	Identity:	127/655 - (19%)
Similarity:	202/655 - (30%)	Gaps:	224/655 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   744 PDNSSTEAYLRHQQRNLTSTPSSSSSEQTSTQQSRH-----RR------SSPANV------YHRY 791
            |..|..|. :..|::..:..|...|:...:|::||.     ||      ||..|:      |.||
Human    36 PPTSQRER-IASQRKTNSEVPMHRSAPSQTTKRSRSPFSTTRRSWDDSESSGTNLNIDNEDYSRY 99

  Fly   792 HPYYYAIT---------------------------TLPTV------VESD--YPP--SLQPHPHP 819
            .|..|..:                           ..|.|      .:.|  |.|  ..:....|
Human   100 PPREYRASGSRRGMAYGHIDSYGADDSEEEGAGPVERPPVRGKTGKFKDDKLYDPEKGARSLAGP 164

  Fly   820 HPHFQP-SQGGSSRSSLSGALNAAAVAATAAAVQAQTFSDLLSQAHNEGRAAALEGNRTPPHTMV 883
            .|||.. |:...........:.||..:|:.|....|  |.:.||:.:||:.|          |..
Human   165 PPHFSSFSRDVREERDKLDPVPAARCSASRADFLPQ--SSVASQSSSEGKLA----------TKG 217

  Fly   884 HAQHQQRQSINPPA-PGVA------SNANLAAAVSPP---PPLEMYSGRSTIPHCGSP------- 931
            .:..::|:..|.|| |..|      ...|.:.:...|   |.:...:.    |:|..|
Human   218 DSSERERREQNLPARPSRAPVSICGGGENTSKSAEEPVVRPKIRNLAS----PNCVKPKIFFDTD 278

  Fly   932 -----PFSVRR-SEAAYSNRQHYQPQPHQGHQAPQNQMHAHIHPPHRASAIVATSLTPAPPYPVH 990
                 |.|..| .:.|..|..|......:|...                   ::|..|.|.||..
Human   279 DDDDMPHSTSRWRDTANDNEGHSDGLARRGRGE-------------------SSSGYPEPKYPED 324

  Fly   991 QNLWYRQQ-SMQEMHRRHMTPTPIDL--------------SSNAPLLTSTLRNGYLHSICSCVHA 1040
            :......| ..:::.||..|....|.              |.:.....:.||..|        .:
Human   325 KREARSDQVKPEKVPRRRRTMADPDFWTHSDDYYKYCDEDSDSDKEWIAALRRKY--------RS 381

  Fly  1041 RNGPVSSLDPAY---------YPPYDAAPAAAAPPPSPQQQSPATSGSGNSSVAAQAS-----MR 1091
            |...:||...::         .||.....|:....|.|...:.|.:|:| :|..:..|     :|
Human   382 REQTLSSSGESWETLPGKEEREPPQAKVSASTGTSPGPGASASAGAGAG-ASAGSNGSNYLEEVR 445

  Fly  1092 HLQLQPQQQPQAQQSPPVMQHMQRQRAIH------HHMFHHHYSPL----HLE------------ 1134
            ...||.:|....:...|.:|:.:...:..      |.:.......|    :||
Human   446 EPSLQEEQASLEEGEIPWLQYHENDSSSEGDNDSGHELMQPGVFMLDGNNNLEDDSSVSEDLEVD 510

  Fly  1135 ----------IGLAP------------LSLGSRILIAPSRPNRGATLETIERNTLPHKYRRVRRP 1177
                      :|:|.            ::|..|  :|.:.....|.||::..:.      .|..|
Human   511 WSLFDGFADGLGVAEAISYVDPQFLTYMALEER--LAQAMETALAHLESLAVDV------EVANP 567

  Fly  1178 SETDEDAEK------------------CAICLNLFEIENEV-RRLPCMHLFHTDCVDQWLVTNKH 1223
            ..:.|..:.                  |.||.:.: ::.|| ..|||.|.||..||..||..:..
Human   568 PASKESIDALPEILVTEDHGAVGQEMCCPICCSEY-VKGEVATELPCHHYFHKPCVSIWLQKSGT 631

  Fly  1224 CPICR 1228
            ||:||
Human   632 CPVCR 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448	17/61 (28%)
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367	17/41 (41%)
PJA1	NP_001369704.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..363		70/362 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..454		16/74 (22%)
		RING-H2_PJA1_2	594..639	CDD:319379	19/44 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1249953at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010