DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6923 and pja2

DIOPT Version :9

Sequence 1:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_009300150.1	Gene:	pja2 / 565118	ZFINID:	ZDB-GENE-060526-337	Length:	661	Species:	Danio rerio

Alignment Length:	577	Identity:	108/577 - (18%)
Similarity:	190/577 - (32%)	Gaps:	149/577 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 RREESSGFEGLARRCDKCSSLDGLCRCESMVASSSRYADSTQNQSH--SEAQFLEQPSSSTAAI- 140
            ||.....|:....:....|::|    |::|..:|.:.:.:.:::.:  |..|.: .|.|.|.::
Zfish    27 RRHAYISFKPFTDKQRATSTVD----CQNMQRTSDQKSQAMESKGNISSVLQTI-LPISCTNSVR 86

  Fly   141 ------ANPPAVHS--------IP--------RPKRKKTEPLTMEPESDNDGDAVVASVSGTWPA 183
                  |:.|..|:        :|        |||..:..|...:..|..:...|       ||.
Zfish    87 PEINAAAHHPEGHNRRHSSLRRVPKAPLNHFKRPKNDQVVPYDRKHCSGREKSKV-------WPI 144

  Fly   184 GAIEEHAMDSTAV------VYEVPSSSLQLSNSSFETAPSAVNAYDDV------TSSASDTEHGQ 236
            .  |.|..:|.|:      .||..||..:..:.|.:.:.:|....|.:      ..|..|:....
Zfish   145 D--ENHKTNSKALSYINIDAYEPDSSGAEEEDLSSDPSHAACRRLDGICELGGNVDSLDDSRSSL 207

  Fly   237 FAHTRTTNTTTTTSAVQAHKKKASRSNNASNTSSRAVDTDATPSTSAQSRKRQMSQFSYRKSRVL 301
            |...|...        .|..|.::...:.:....|.|.|:..||...:....:.  :....|.|.
Zfish   208 FRKNRMKQ--------MASSKDSTDLFDDTPDCQRTVKTNGKPSFFLEDGAPKC--YGDTASAVS 262

  Fly   302 EPENESSDDGWDLRVHNPVPP---IEPTVTIIRGSRGSDEAEIGHTDHNYYNSRCAVAGAPPDST 363
            ....|.::.|........|.|   .:.:.|.:...:.|::.|.||...:...::|  ..|||.
Zfish   263 HKNTEQNNPGETFESEMVVRPKIRKQTSETHLERRKRSEKEETGHLSGSAIRNKC--GSAPPG-- 323

  Fly   364 YIRSASCSTATHTTRSVDYGSRIGRRSAATGSPSTSSDQEQEQQQ-RQQQEEIIHEERRHQQSPG 427
             ..:.:|..          ...:....|...|...|.|::.|.:. :.:.|:.|.|:..:.....
Zfish   324 -FLAQTCPE----------NKFLFNFPAMALSDLNSEDRKSEDENAKVEDEDDIWEDLENFGEKC 377

  Fly   428 QPMHSMYGVPGESRMS---WSRARPSDDSVPPRKHARMELPGRSRSKLSSTNFNSFYPGRRGHRT 489
            :|  ||......|..|   ||.:..||.             |..:.:.:|.......||
Zfish   378 EP--SMKADESSSEFSEGEWSASWTSDS-------------GLDKERCTSEESWETLPG------ 421

  Fly   490 FAEQGNSSGQHHVRFPPSSTPNSNGPCVITYVGRPRDSQPAADLNLPSTSTGRRGSHETRADSVV 554
                        :..||:|..:|            .:..|:.:|.|...:....|.
Zfish   422 ------------IDEPPASRSSS------------LEEVPSLNLALEEQTPLEEGE--------- 453

  Fly   555 LTAPDLQL--DDWSSDDDDDDVV--FVHSTREPILSIDLTSDDDGLANDTQLQRDRD 607
              .|.|..  |..||.|:|.|.|  |||.      .:.:...::.|.:|:.:..|.|
Zfish   454 --IPWLMYNEDSGSSSDEDPDGVSQFVHP------GLFILDGNNNLEDDSSMSEDLD 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367
pja2	XP_009300150.1	zf-RING_2	588..629	CDD:290367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1249953at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010