DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6923 and rlim

DIOPT Version :9

Sequence 1:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_009306042.1	Gene:	rlim / 562487	ZFINID:	ZDB-GENE-120809-2	Length:	638	Species:	Danio rerio

Alignment Length:	780	Identity:	158/780 - (20%)
Similarity:	237/780 - (30%)	Gaps:	306/780 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   593 DDGLANDTQLQRDRDRGRERERERA-------RDREPYR-----------------------NDT 627
            |.|.::.:::||.|...| .:||.|       ...|.||                       ...
Zfish     8 DQGSSDQSEIQRRRQLDR-LDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGEITADELLNRLRQV 71

  Fly   628 QPNPEDPN----EDRR------------------TMYDCAYTFPYARRTDRRTEANNEGTSAFAF 670
            :..||.|:    |:||                  |:.|...|   .|:|...|.:...|..::
Zfish    72 KDGPESPSSNITEERREAPGATEVEGTEENPSGETLLDWLNT---VRQTGNTTRSGYRGNQSW-- 131

  Fly   671 YSGALADRAAISDHNYSYELDQLMDPGPGNFYPPRCSNMDPQRYFLPIN---------------E 720
                    .|:|..|          |..|:|           |:.|.||               |
Zfish   132 --------RAVSQTN----------PNSGDF-----------RFSLEINVNRNIAEQQTQTERLE 167

  Fly   721 SSMWMPGHPAPPP-----------------------PPPPMPPILL---PDNSSTEAYLRHQQRN 759
            .|...|......|                       |..|:|..|.   .||...:|     ...
Zfish   168 GSQERPDGSVSEPESLMETAEVVEEPVVDELAVIVEPELPVPSTLTLNRDDNVPVDA-----PNP 227

  Fly   760 LTSTP----------------SSSSSEQTSTQQSRHRRSSPANVYHRYHPYYYAITTLPTVVESD 808
            |||||                .|.|.||..|:....|..||.|:...                ..
Zfish   228 LTSTPPNLPSVEQPRRGQIRARSRSPEQRRTRARTARGRSPINLERL----------------DG 276

  Fly   809 YPPSLQPHPHPHPHF--QPSQGGSSRSSLSGALNAAAVAATAAAVQAQTF----SDLLSQAHNEG 867
            .||:....|..:|..  :|...||||:                   .|.|    |.:.::.|..|
Zfish   277 LPPTQHGIPTHNPEILPEPQVEGSSRT-------------------RQLFLSRQSTVETETHTLG 322

  Fly   868 RAAALEGNRTPPHTMVHAQHQQRQSINPPAPGVASNANLAAAVSPPPPLEM-----------YSG 921
            .|           |.|....|:|:         |:.....|:...||.:.:           |..
Zfish   323 SA-----------TDVPEAPQERE---------ATTGEAGASGRRPPTIMLDLQVRRVRPGEYRQ 367

  Fly   922 RSTIPHCGSPPFSVRRSEAAYSN------------RQHYQPQPHQGHQAPQNQMHAHIHPPHRAS 974
            |.:|.       :..||.:..||            |:.:......|.:...:.:...|.....|.
Zfish   368 RDSIA-------NRTRSRSQTSNNTLLYETERGGFRRTFSRSERAGVRTYVSTIRIPIRRISDAG 425

  Fly   975 AIVATSLTPAPPYPVHQNLWYRQQSMQEMHRRHMTPTPIDLSSNAPLLTSTLRNGYLHSICSCVH 1039
            ...||||                 ::|.|.|:.||... :||.            ::.:.....:
Zfish   426 LGEATSL-----------------ALQSMIRQIMTGFG-ELSY------------FMEAEVPDSN 460

  Fly  1040 ARNGPVSSLDPAYYPPYDAAPAAAAPPPSPQQQSPATSGSGNSSVAAQASMRHLQ--LQPQQQPQ 1102
            ..:.|.:.|..|...| ||:....|....|  ..|...|.....:.|:...|.::  |.....|:
Zfish   461 REDNPPADLSDALGNP-DASTGTGASEADP--YLPGHGGLNQGGLEARTEEREVEGGLPGAAGPR 522

  Fly  1103 AQQSPPVMQHMQRQRAIHHHMFHHHYSPLHL-EIGLAP-LSLGSRILIAPSRPN--RGATLETIE 1163
                    ::..||||           |::| |.|..| |.|....|:.....:  ||.|.|.|:
Zfish   523 --------ENRGRQRA-----------PINLDETGSLPFLRLAHFFLLNEEDDDQPRGLTKEQID 568

  Fly  1164 RNTLPHKYRRVRRPSETDEDAEKCAICLNLFEIENEVRRLPCMHLFHTDCVDQWLVTNKHCPICR 1228
            ..::       |...|:|. .:.|::|:..:...|::|:|||.|.:|..|:|:||..|..|||||
Zfish   569 NLSM-------RNFGESDA-FKTCSVCITEYAEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICR 625

Fly 1229 1228
Zfish 626 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448	17/42 (40%)
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367	17/40 (43%)
rlim	XP_009306042.1	zf-RING_2	583..625	CDD:290367	17/41 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910