DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6923 and RLIM

DIOPT Version :9

Sequence 1:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_057204.2	Gene:	RLIM / 51132	HGNCID:	13429	Length:	624	Species:	Homo sapiens

Alignment Length:	897	Identity:	171/897 - (19%)
Similarity:	269/897 - (29%)	Gaps:	357/897 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 GSPSTSSDQEQEQQQRQQQEEIIH--------EERRHQQSPGQPMHSMYGVPGESRMS--WSRAR 448
            ||...|:.|.:.|..|..:||..:        |:.|..:.     :::.|.||||...  ..|.:
Human    10 GSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRD-----NNLLGTPGESTEEELLRRLQ 69

  Fly   449 PSDDSVPPRKHARMELPGRSRSKLSSTNFNSFYPGRRGHRTFAEQGNSSGQHHVRFPPSSTPNSN 513
            ...:..||:                    ||             ..|..|.       ||...||
Human    70 QIKEGPPPQ--------------------NS-------------DENRGGD-------SSDDVSN 94

  Fly   514 GPCVITYVGRPRDSQPAADLNLPSTSTGRRGSHETRADSVVLTAPDLQLDDWSSDDDDDDVVFVH 578
            |..:|.::...|.:.       .:|.:|:||:...||.|             .::.:..|..|
Human    95 GDSIIDWLNSVRQTG-------NTTRSGQRGNQSWRAVS-------------RTNPNSGDFRF-- 137

  Fly   579 STREPILSIDLTSDDDGLANDTQLQRDRDRGRERERERARDREPYRNDTQPNPEDPNEDRRTMYD 643
                   |:::..:                               ||:...|.|:.||
Human   138 -------SLEINVN-------------------------------RNNGSQNSENENE------- 157

  Fly   644 CAYTFPYARRTDRRTEANNEGTSAFAFYSGALADRAAISDHNYSYELDQLMDPGPGNFYPPRCSN 708
                 |.|||:......||.
Human   158 -----PSARRSSGENVENNS--------------------------------------------- 172

  Fly   709 MDPQRYF-LPINESSMWMPGHPAPPPPPPPMPPILLPDNSSTEAYLRHQQRNLTSTPSSSSSEQT 772
               ||.. .|.:||:...|..               .:.:||||        ||..|.:....:.
Human   173 ---QRQVENPRSESTSARPSR---------------SERNSTEA--------LTEVPPTRGQRRA 211

  Fly   773 STQQSRHRRS--------SPANVYHRYHPYYYAITTLPTVVESDYP----PSLQPHPHPHPHFQP 825
            .::...|||:        ||      .||.            |:.|    .|:......||....
Human   212 RSRSPDHRRTRARAERSRSP------LHPM------------SEIPRRSHHSISSQTFEHPLVNE 258

  Fly   826 SQGGSS-------RSSLSG----ALNAAAVAATAAAVQAQTFSDLLSQAHNEGRAAALEGNRTPP 879
            ::|.|.       |..:||    :....|.:.|..|.|....||..:...:.|     .|.| ||
Human   259 TEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAASGESTG-----SGQR-PP 317

  Fly   880 HTMVHAQ--------HQQRQSINPPAPGVASNANLAAAVSPPPPLEMYSGRSTIPHCGSPPFSVR 936
            ..::..|        ::||.||       ||...               .||..|:
Human   318 TIVLDLQVRRVRPGEYRQRDSI-------ASRTR---------------SRSQTPN--------- 351

  Fly   937 RSEAAY-SNRQHYQPQPHQGHQAPQNQMHAHIHPPHRASAIVATSLTPAPPYPVHQNLWYRQQSM 1000
             :...| |.|..::....:..:|......:.|..|.|  .|:.|.|:..           ...::
Human   352 -NTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIR--RILNTGLSET-----------TSVAI 402

  Fly  1001 QEMHRRHMT--------------PTPIDLSSNAPLLTSTLRNGYLHSICSCVHARNGPVSSLDPA 1051
            |.|.|:.||              ..|....||..:..:..|:|         ...:|..||...:
Human   403 QTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSG---------RGGSGGGSSSGSS 458

  Fly  1052 YYPPYDAAPAAAAPPPSPQQQSPATSGSGNSSVAAQASMRHLQLQPQQQPQAQQSPPVMQHMQRQ 1116
                ..::.::::...|....||::|..|.||..:..     ..:...:..:.......:...|.
Human   459 ----SSSSSSSSSSSSSSSSSSPSSSSGGESSETSSD-----LFEGSNEGSSSSGSSGARREGRH 514

  Fly  1117 RAIHHHMFHHHYSPLHL-EIGLAP-LSLGSRILIAPSRPN--RGATLETIERNTLPHKYRRVRRP 1177
            ||           |:.. |.|..| |||....|:.....:  ||.|.|.|:         .:...
Human   515 RA-----------PVTFDESGSLPFLSLAQFFLLNEDDDDQPRGLTKEQID---------NLAMR 559

  Fly  1178 SETDEDAEK-CAICLNLFEIENEVRRLPCMHLFHTDCVDQWLVTNKHCPICR 1228
            |..:.||.| |::|:..:...|::|:|||.|.:|..|:|:||..|..|||||
Human   560 SFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICR 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448	18/43 (42%)
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367	17/40 (43%)
RLIM	NP_057204.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		5/14 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..251		58/379 (15%)
		PHA03307	159..>348	CDD:223039	54/305 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..276		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..363		23/109 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..522		19/126 (15%)
		RING_Ubox	568..612	CDD:388418	20/44 (45%)
		PDZ-binding. /evidence=ECO:0000255	621..624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910