DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6923 and RNF165

DIOPT Version :9

Sequence 1:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_689683.2	Gene:	RNF165 / 494470	HGNCID:	31696	Length:	346	Species:	Homo sapiens

Alignment Length:	389	Identity:	120/389 - (30%)
Similarity:	158/389 - (40%)	Gaps:	113/389 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   918 MYSGRSTIPHCGSPPFSVRRSEAAYSNRQHYQ-----------PQPHQGHQAP--------QNQ- 962
            ::.|...:|..|    |||...|.:...||..           |||.|  .||        |:|
Human     4 VHVGYLVLPVFG----SVRNRGAPFQRSQHPHATSCRHFHLGPPQPQQ--LAPDFPLAHPVQSQP 62

  Fly   963 -MHAHIHPPHRASAIVATSLTPAP-------------PYPVHQNLWYRQQSMQEMHRRHMTPTPI 1013
             :.||:.|.|:.|..:..||||.|             |..:||....:||.::..|||.::
Human    63 GLSAHMAPAHQHSGALHQSLTPLPTLQFQDVTGPSFLPQALHQQYLLQQQLLEAQHRRLVS---- 123

  Fly  1014 DLSSNAPLLTSTLRNGYLHSICSCVHARNGP--VSSLDPAYYPPYDAAPAAAAPPPSPQQQSPAT 1076
                                     |.|...  ||......:|.:|....     .:||.:..|.
Human   124 -------------------------HPRRSQERVSVHPHRLHPSFDFGQL-----QTPQPRYLAE 158

  Fly  1077 SGSGNSSVAAQASMRHLQLQP-QQQPQAQQSPPVMQHMQRQ----RAIHHHMFHHHYSPLHLEI- 1135
            ....:.||.|..|....|::| .|..|...:.|.|.|..|.    :.:.|.:.::.|..||...
Human   159 GTDWDLSVDAGLSPAQFQVRPIPQHYQHYLATPRMHHFPRNSSSTQMVVHEIRNYPYPQLHFLAL 223

  Fly  1136 -GLAP--------------LSLGSRILIAPSRPNRGATLETIERNTLPHKYRRVRRP-------- 1177
             ||.|              |.|..|:    ....|||...||||.|.||||:: |||
Human   224 QGLNPSRHTSAVRESYEELLQLEDRL----GNVTRGAVQNTIERFTFPHKYKK-RRPQDGKGKKD 283

  Fly  1178 --SETDEDAEKCAICLNLFEIENEVRRLPCMHLFHTDCVDQWLVTNKHCPICRVDIETHMPNDA 1239
              .|:|.| |||.|||::.|...:|||||||||||..||||||..:|.||||||||||.:..|:
Human   284 EGEESDTD-EKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICRVDIETQLGADS 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448	28/42 (67%)
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367	26/40 (65%)
RNF165	NP_689683.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..76		14/54 (26%)
		Ubiquitin binding. /evidence=ECO:0000269\|PubMed:26656854, ECO:0007744\|PDB:5D0K	266..268		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..288		7/21 (33%)
		RING-H2_RNF111_like	292..337	CDD:319388	30/44 (68%)
		Ubiquitin binding. /evidence=ECO:0000269\|PubMed:26656854, ECO:0007744\|PDB:5D0K	309..313		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141574
Domainoid	1	1.000	77	1.000	Domainoid score	I8869
eggNOG	1	0.900	-	-		E33208_3BBW1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003192
OrthoInspector	1	1.000	-	-		otm42116
orthoMCL	1	0.900	-	-		OOG6_110422
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1977
SonicParanoid	1	1.000	-	-		X3096
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760