DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6923 and SPCC4G3.12c

DIOPT Version :9

Sequence 1:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_587826.1	Gene:	SPCC4G3.12c / 2539364	PomBaseID:	SPCC4G3.12c	Length:	821	Species:	Schizosaccharomyces pombe

Alignment Length:	835	Identity:	158/835 - (18%)
Similarity:	255/835 - (30%)	Gaps:	315/835 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   622 PYRNDTQPNPEDPNEDRRTMYDCAYTFP-----YARRTDRRTEANNEGTSAFAFY------SGAL 675
            |.||....:...|:|...|......|.|     |:......|.|.::.:.|..::      ||..
pombe    62 PSRNTPNSSNGFPSETLVTSSAHCSTQPHKDEAYSHHGYSSTMALDDSSLAQTYHEYEEGTSGNS 126

  Fly   676 ADRAAISDHNYSYELDQLMDPGP-GN--------------------FYPPRCSNMDPQR-----Y 714
            ..|.||..:::       :.|.| ||                    |.....|:.||.:     |
pombe   127 PLRRAIGSYDF-------LHPRPSGNSSRLDRNSSRPFTSSFHSAPFLSSYGSSNDPSQERVNEY 184

  Fly   715 FLPINESSMWMPGHPAPPPPPP--------PMPPIL----LPDNSST--------EAYLRHQQRN 759
            .||.|.:|.:         ..|        |:|.:|    |.:||..        ..||......
pombe   185 SLPSNSNSTY---------TTPLQSINNEHPLPTVLENNALLNNSGNSPSLINHLRQYLNQDFSR 240

  Fly   760 LTSTPSSSSSEQTSTQQSRHRRSSPANVYHRYHPYYYAITTLPTVVESDYPPSL--QPHPHPHPH 822
            |..:||...:...:..|:  ||||.:::...:               :|:|...  ..:|..|.:
pombe   241 LHQSPSPIPNSNDNDSQT--RRSSWSSIASAF---------------NDFPEEFPNASNPEAHSN 288

  Fly   823 FQPSQGG--SSRSSLSGALNAAAVAATAAAVQAQ----------------------TFSDLL--- 860
            |.|..|.  |:.:.||..|:|||:...|:.:.::                      :|...|
pombe   289 FTPLNGNDESTVNMLSRLLSAAAIETVASIMNSEARNMDSQNMANGEPSRFRSVDGSFEQFLTDL 353

  Fly   861 ------------SQAHNEGRAAALEGN----------RTPPHTMVHAQHQQRQSINPPAPGVASN 903
                        ||..|:..::..|.|          |.|   ..|..|.|     |.:...||:
pombe   354 RSGNLTNVLQNSSQNGNDQISSDPESNSSDLQYLRMFRFP---SFHQSHNQ-----PASNNEASD 410

  Fly   904 ANLAAAVSPPPPLEMYSGRSTIPHCGSPPFSVRRSEAAYSNRQHYQPQPHQGHQAPQNQMHAHI- 967
            .|..|.|    |:.:...||.             ||.:    :.:.|...|.:|:..|:...:|
pombe   411 TNGPALV----PVLIVCMRSI-------------SETS----EDHAPTMTQENQSLHNESRENIS 454

  Fly   968 ------------------------------HP-PHR---ASAIVATSLTPAPPYPVHQNLW---- 994
                                          || |.|   :.|....|..||..:|..:||:
pombe   455 INDITERMAQSTEFSTDLPPTFERSNSTFSHPEPTRSDFSQAFTPVSDFPANLFPGSRNLFPTSN 519

  Fly   995 YRQQSMQEMHRRHMTPTPIDLSSNA-------PLLTSTLRNGYLHSICSCVHARNGPVSSLDPAY 1052
            ...||.....|.:.....:||.:::       |:..||..|          |..:..:|||
pombe   520 SGNQSTSSFSRYNQPTVSVDLRNSSILRRAQEPVNGSTGEN----------HIGDDYISSL---- 570

  Fly  1053 YPPYDAAPAAAAPPPSPQQQSPATSGSGNSSVAAQASMRHLQLQPQQQPQAQQSPPVMQHMQR-Q 1116
               .|::        :...|.|.::....|:|.::.:..:..:....||....:........| .
pombe   571 ---LDSS--------NSNSQRPFSTVPSESNVFSRNASGNFSMSQTHQPTTDNTSSFSTQPGRLS 624

  Fly  1117 RAIHH--------------------HMFHHHYSPLHLEIGLAPL-SLGSRILIAPSR-------- 1152
            ..:||                    :.|....|........:.| |.|:..::..:.
pombe   625 TGLHHFPSDRDLLSNQTRRSSLARSYRFEEQLSVDDNTSDFSTLASNGAADMVTQTHSEGTFSNS 689

  Fly  1153 --------------PNRGATLETIERNTLPHKYRRV----------RRPSETDED---------- 1183
                          |.....|.|:...:....|..:          ::|..:.||
pombe   690 THGDWLIYVFGGLFPEHHPVLSTVSLFSDNPMYEDLLALTTYLGPAKKPVASHEDVKRSGGLFAY 754

  Fly  1184 --------AEKCAICLNLFEIENEVRRL-PCMHLFHTDCVDQWLVT-NKHCPICR 1228
                    |:.|.|||..:...:..|:| .|.|.||..|:||||.| |..||:||
pombe   755 FDDASLSSADSCLICLETYTNGDICRKLQACKHFFHQACIDQWLTTGNNSCPLCR 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448	19/44 (43%)
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367	19/42 (45%)
SPCC4G3.12c	NP_587826.1	zf-RING_2	764..809	CDD:290367	19/44 (43%)
SPCC4G3.12c	NP_587826.1	zf-rbx1	<764..809	CDD:289448	19/44 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	57	1.000	Domainoid score	I3109
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1977
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940