DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6923 and Rnf44

DIOPT Version :9

Sequence 1:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_001139497.1	Gene:	Rnf44 / 105239	MGIID:	2145310	Length:	432	Species:	Mus musculus

Alignment Length:	541	Identity:	124/541 - (22%)
Similarity:	182/541 - (33%)	Gaps:	175/541 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   727 GHPAPPPPPPPMPPILLPDNSSTEAYLRHQQRNLTSTPSSSSSEQTSTQQSRHRRSSPANVYHR- 790
            ||..|...||           :.:..|..||  |...||:.|.|:       ||.|:||....|
Mouse    38 GHEGPLVSPP-----------AQDERLPSQQ--LLPRPSNLSVEE-------HRASAPAGRSPRM 82

  Fly   791 YHPYYYAITTLPTVVESDYPPSLQPHPHPHPHFQPSQGGSSRSSLSGALNAAAVAATAAAVQAQT 855
            .||   |....|.:|:.              |.|..||            ...::.|...|..|.
Mouse    83 LHP---ATQQSPFMVDL--------------HEQVHQG------------PVPLSYTVTTVTTQG 118

  Fly   856 FSDLLSQAHNEGRAAALEGNRTPPHTMVHAQHQQRQSINPPAPGVASNANLAAAVSPPPPLEMYS 920
            |                     |..|..|            .||.::....|.:|       |:|
Mouse   119 F---------------------PLPTSQH------------IPGCSAQQLPACSV-------MFS 143

  Fly   921 GRSTIPHCGSPPFSVRRSEAAYSNRQHYQPQPHQGHQAPQNQMHAHIHPPHRASAIVATSLTPA- 984
            |:. .|.|..||     .:...:......|.|:..:....:..|..:|||           .||
Mouse   144 GQH-YPLCCLPP-----PQLIQACTMQQLPGPYHTYPHLISSDHYILHPP-----------PPAP 191

  Fly   985 PPYPVHQNLWYRQQSMQEMHRRHMTPTPIDLSSNAPLLTSTLRNGYLHSICSCVHARN--GP-VS 1046
            ||.|.|.....:..|:|..|.|    .|:....|...|     .|..|.:.|..::.:  || :|
Mouse   192 PPQPTHMAPLGQFVSLQTQHPR----MPLQRLDNEMDL-----RGDQHPLGSFTYSTSATGPALS 247

  Fly  1047 SLDPAYYPPYDAAPAAAAPPPSPQQQSPATSGSGNSSVAAQASMRHLQLQPQQQPQAQQSPPVMQ 1111
            ...|.:|.|:|           |..|..:.....:..:..:.|.:..:||....|.....||
Mouse   248 PSVPLHYLPHD-----------PLHQELSFGVPYSHMMPRRLSTQRYRLQQPLPPPPPPPPP--- 298

  Fly  1112 HMQRQRAIHHHMFHHHYSPLHLE-IGLAPLSLGSRI----------------------LIAPSRP 1153
                       .::..:.|..|. :.::|.::|..|                      .:..::|
Mouse   299 -----------SYYPSFLPYFLSMLPMSPTTVGPTISLDLDVDDVEMENYEALLNLAERLGDAKP 352

  Fly  1154 NRGATLETIERNTLPHKYRRVRRPSETDEDAEKCAICLNLFEIENEVRRLPCMHLFHTDCVDQWL 1218
             ||.|...||:  || .||  ..|.....:...|.:|.:.||:...:|.|||.|.||..|||:||
Mouse   353 -RGLTKADIEQ--LP-SYR--FNPDSHQSEQTLCVVCFSDFEVRQLLRVLPCNHEFHAKCVDKWL 411

  Fly  1219 VTNKHCPICRVDIETHMPNDA 1239
            ..|:.|||||.| .:.:|.:|
Mouse   412 KANRTCPICRAD-ASEVPREA 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448	20/42 (48%)
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367	20/40 (50%)
Rnf44	NP_001139497.1	RING-H2_RNF38_like	377..421	CDD:319386	20/43 (47%)
Rnf44	NP_001139497.1	RING-H2 finger (C3H2C3-type)	380..420	CDD:319386	19/39 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910