Protein Alignment CG14722 and WDR55

DIOPT Version :10

• Sequence 1: NP_650111.3
• Gene: CG14722 / 41419
• FlyBaseID: FBgn0037943
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_060176.3
• Gene: WDR55 / 54853
• HGNCID: 25971
• Length: 383
• Species: Homo sapiens
• Alignment Length: 378
• Identity: 127/378 - (33%)
• Similarity: 201/378 - (53%)
• Gaps: 25/378 - (6%)

  Fly   129 DDETDETVRAMIAAIKKPRSSPPEIKLEDFITDICFHPDRDIIALATIIGDVHLYEY---DNEAN 190
            :|.:||.....:.|..:.|.:|.:|.||...:.:.|||.||::|...:.|||.::.|   :.|..
Human    11 EDGSDEEDPDSMEAPTRIRDTPEDIVLEAPASGLAFHPARDLLAAGDVDGDVFVFSYSCQEGETK 75

  Fly   191 KLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLKKLYETAHDDAINTLHVLNEN 255
            :|..:.. |.||||.|.|:|||:.|:|.||||.:.|.|:|..:|::....||...||:|.:::||
Human    76 ELWSSGH-HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDEN 139

  Fly   256 LFASGDDAGTVKLWDLRTKNAIFELKELEDQITQLTTNEQSKLLLATSADGYLTTFNISARKMYV 320
            :.|:|||.|.:.|||.|.:..:.::::.|:.|..:..:...||||..|.||.|..|||..|:..:
Human   140 VLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFEL 204

  Fly   321 QSEPYEEELNCMGVYRGDSKLVVGTSKGRLYTYNWGQFGYHCDMYPGIKSPISLMIPITDRIACV 385
            .|||...:|..:.:.:...|:..|:|:|.:|.:||..||...|.:......|..|:|:|:.:.|.
Human   205 LSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCT 269

  Fly   386 AGEDGNIRACHIAPYRNLGVVGQH-NMPIESLDVNASGELIASSSHNNDVRFWNVKYFEDFGDIK 449
            ...||.|||.:|.|.|.:|.|||| ..|:|.|.::..|..:|||.|:..::||      |...::
Human   270 GSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFW------DMAQLR 328

  Fly   450 YNEKHNAYKEQRHNLP----SSKCSNASDFFSDLTKENAD----------GDD 488
            .....:..:.::...|    |||..:..|||:.|.:|..|          |||
Human   329 AVVVDDYRRRKKKGGPLRALSSKTWSTDDFFAGLREEGEDSMAQEEKEETGDD 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14722	NP_650111.3	WD40	156..438	CDD:475233	104/285 (36%)
		WD40 repeat	160..198	CDD:293791	12/40 (30%)
		WD40 repeat	203..239	CDD:293791	17/35 (49%)
		WD40 repeat	247..284	CDD:293791	13/36 (36%)
		WD40 repeat	287..354	CDD:293791	22/66 (33%)
		WD40 repeat	367..406	CDD:293791	14/38 (37%)
		WD40 repeat	413..437	CDD:293791	7/23 (30%)
WDR55	NP_060176.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		5/21 (24%)
		WD 1	36..75		13/38 (34%)
		WD40	39..332	CDD:441893	105/299 (35%)
		WD40 repeat	42..81	CDD:293791	12/38 (32%)
		WD 2	82..121		20/39 (51%)
		WD40 repeat	88..125	CDD:293791	16/36 (44%)
		WD 3	125..163		16/37 (43%)
		WD40 repeat	130..165	CDD:293791	14/34 (41%)
		WD 4	166..205		14/38 (37%)
		WD40 repeat	172..206	CDD:293791	12/33 (36%)
		WD 5	208..247		11/38 (29%)
		WD40 repeat	213..250	CDD:293791	11/36 (31%)
		WD 6	250..289		13/38 (34%)
		WD 7	293..332		12/44 (27%)
		WD40 repeat	298..322	CDD:293791	7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..383		5/19 (26%)