DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14721 and Tpk1

DIOPT Version :9

Sequence 1:	NP_650110.3	Gene:	CG14721 / 41417	FlyBaseID:	FBgn0037942	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_001128466.1	Gene:	Tpk1 / 680668	RGDID:	1589408	Length:	243	Species:	Rattus norvegicus

Alignment Length:	266	Identity:	103/266 - (38%)
Similarity:	148/266 - (55%)	Gaps:	33/266 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 MDHTIPPKEYKWTPGNLINENFKLGDHGHVCVVLNRQIQVPAHVVKLLWKNAAVRCAVDGGSNHW 135
            |:|...|.|.....|:|   .|.|       ||||:.:.  .| .:.||:.|.:|...|||:||.
  Rat     1 MEHVFTPLEPLLPTGDL---KFCL-------VVLNQTLD--PH-FRHLWRKALLRACADGGANHL 52

  Fly   136 RDFVVAQAMSKKANGSAPTTPLEPLDVITGDFDSITEETVDFF--KTTPKVHTPDQDATDFTKAM 198
            .|....:..|           ..| :.|.||||||..|..:::  |....:.|||||.|||||.:
  Rat    53 YDLTEGERES-----------FLP-EFINGDFDSIRPEVKEYYTKKGCDLISTPDQDHTDFTKCL 105

  Fly   199 AVLQPVMTQRKIQ-DVVV-FHDTSGRLDQVMANLNTLYKSQK-DNCNVFLLSGDSVTWLLRPGKH 260
            .|||..:.::::| ||:| .....||.||:||::|||:::.. ....:.::..:|:.:||:||||
  Rat   106 QVLQRKIEEKELQVDVIVTLGGLGGRFDQIMASVNTLFQATDIIPVPIIIIQKESLIYLLQPGKH 170

  Fly   261 TIQVPVDLVTSQRWCSLMPVGSSAHNVTTTGLKWNLYHAQLEFGGMVSTSNTY-ATEFVQVETDA 324
            .::|...:..|  ||.|:|||...::||||||||||.:..|.||.:||||||| .:..|.||||.
  Rat   171 RLRVDTGMEGS--WCGLIPVGQPCNHVTTTGLKWNLTNDVLGFGTLVSTSNTYDGSGLVTVETDH 233

  Fly   325 NLIWSM 330
            .|:|:|
  Rat   234 PLLWTM 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14721	NP_650110.3	TPK	100..328	CDD:153431	93/233 (40%)
CG14721	NP_650110.3	thi_PPkinase	101..330	CDD:273588	94/234 (40%)
Tpk1	NP_001128466.1	TPK	20..239	CDD:153431	95/242 (39%)
Tpk1	NP_001128466.1	PLN02714	21..241	CDD:178316	96/243 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340691
Domainoid	1	1.000	77	1.000	Domainoid score	I8664
eggNOG	1	0.900	-	-		E1_COG1564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6960
Inparanoid	1	1.050	152	1.000	Inparanoid score	I4267
OMA	1	1.010	-	-		QHG54595
OrthoDB	1	1.010	-	-		D1428589at2759
OrthoFinder	1	1.000	-	-		FOG0005247
OrthoInspector	1	1.000	-	-		oto98315
orthoMCL	1	0.900	-	-		OOG6_101973
Panther	1	1.100	-	-	LDO	PTHR13622
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3766
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770