DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14721 and TPK1

DIOPT Version :9

Sequence 1:	NP_650110.3	Gene:	CG14721 / 41417	FlyBaseID:	FBgn0037942	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	XP_011514333.1	Gene:	TPK1 / 27010	HGNCID:	17358	Length:	269	Species:	Homo sapiens

Alignment Length:	292	Identity:	96/292 - (32%)
Similarity:	140/292 - (47%)	Gaps:	59/292 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 MDHTIPPKEYKWTPGNLINENFKLGDHGHVCVVLNRQIQVPAHVVKLLWKNAAVRCAVDGGSNHW 135
            |:|...|.|...:.|||          .:..|:||:.:.   :..:.||..|.:|...|||:|..
Human     1 MEHAFTPLEPLLSTGNL----------KYCLVILNQPLD---NYFRHLWNKALLRACADGGANRL 52

  Fly   136 RDFVVAQAMSKKANGSAPTTPLEPLDVITGDFDSITEETVDFFKT-------------------- 180
            .|....:..|           ..| :.|.||||||..|..:::.|
Human    53 YDITEGERES-----------FLP-EFINGDFDSIRPEVREYYATKVLIFSILGTSFKEEKEPFS 105

  Fly   181 --------TPKVHTPDQDATDFTKAMAVLQPVMTQR--KIQDVVVFHDTSGRLDQVMANLNTLYK 235
                    ...:.|||||.|||||.:.:||..:.::  |:..:|.....:||.||:||::|||::
Human   106 GRREEKKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQ 170

  Fly   236 SQK-DNCNVFLLSGDSVTWLLRPGKHTIQVPVDLVTSQRWCSLMPVGSSAHNVTTTGLKWNLYHA 299
            :.. ....:.::..:|:.:||:||||.:.  ||......||.|:|||.....||||||||||.:.
Human   171 ATHITPFPIIIIQEESLIYLLQPGKHRLH--VDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTND 233

  Fly   300 QLEFGGMVSTSNTY-ATEFVQVETDANLIWSM 330
            .|.||.:||||||| .:..|.||||..|:|:|
Human   234 VLAFGTLVSTSNTYDGSGVVTVETDHPLLWTM 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14721	NP_650110.3	TPK	100..328	CDD:153431	87/259 (34%)
CG14721	NP_650110.3	thi_PPkinase	101..330	CDD:273588	88/260 (34%)
TPK1	XP_011514333.1	TPK	20..265	CDD:153431	88/261 (34%)
TPK1	XP_011514333.1	PLN02714	21..267	CDD:178316	89/262 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147027
Domainoid	1	1.000	72	1.000	Domainoid score	I9377
eggNOG	1	0.900	-	-		E1_COG1564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6960
Inparanoid	1	1.050	148	1.000	Inparanoid score	I4410
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54595
OrthoDB	1	1.010	-	-		D1428589at2759
OrthoFinder	1	1.000	-	-		FOG0005247
OrthoInspector	1	1.000	-	-		oto91230
orthoMCL	1	0.900	-	-		OOG6_101973
Panther	1	1.100	-	-	LDO	PTHR13622
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1532
SonicParanoid	1	1.000	-	-		X3766
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800