DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14721 and tnr3

DIOPT Version :9

Sequence 1:	NP_650110.3	Gene:	CG14721 / 41417	FlyBaseID:	FBgn0037942	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_593291.1	Gene:	tnr3 / 2543032	PomBaseID:	SPAC6F12.05c	Length:	569	Species:	Schizosaccharomyces pombe

Alignment Length:	239	Identity:	74/239 - (30%)
Similarity:	122/239 - (51%)	Gaps:	27/239 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 DHGHVCVVLNRQIQVPAHVVKLLWKNAAVRCAVDGGSNHWRDFVVAQAMSKKANGSAPTTPLEPL 160
            |.....::||:.|.:|....:.|||.|::|...|||:|..|::               .:.|:|
pombe   350 DQKFAVLLLNQPIDIPDDRFRTLWKRASIRVCADGGANQLRNY---------------DSSLKP- 398

  Fly   161 DVITGDFDSITEETVDFFKT--TPKVHTPDQDATDFTKAMAVLQPVMTQRKIQDVVVFHDTSGRL 223
            |.:.|||||:|:||..::|.  ...|..|.|:.|||.|...:::    :..|..:.|.....||:
pombe   399 DYVVGDFDSLTDETKAYYKEMGVNIVFDPCQNTTDFMKCHKIIK----EHGIDTIFVLCGMGGRV 459

  Fly   224 DQVMANLNTLY--KSQKDNCNVFLLSGDSVTWLLRPGKHTIQVPVDLVTSQRWCSLMPVGSSAHN 286
            |..:.|||.|:  .|..:...||||:..:|:.||:||.:.:....::...   |.|:|||.|.:.
pombe   460 DHAIGNLNHLFWAASISEKNEVFLLTELNVSTLLQPGINHVDCHDNIGLH---CGLLPVGQSVYV 521

  Fly   287 VTTTGLKWNLYHAQLEFGGMVSTSNTYATEFVQVETDANLIWSM 330
            ..|:||:||:.....:|||:||:.|......|.:|.:..::|:|
pombe   522 KKTSGLEWNIEDRICQFGGLVSSCNVVTKATVTIEVNNFIVWTM 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14721	NP_650110.3	TPK	100..328	CDD:153431	71/231 (31%)
CG14721	NP_650110.3	thi_PPkinase	101..330	CDD:273588	72/232 (31%)
tnr3	NP_593291.1	DUF4743	33..131	CDD:292538
		Nudix_hydrolase_3	103..282	CDD:239648
		TPK	354..562	CDD:153431	71/230 (31%)
		thi_PPkinase	355..565	CDD:273588	72/232 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	61	1.000	Domainoid score	I3000
eggNOG	1	0.900	-	-		E1_COG1564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1532
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.800