DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14718 and NRP1

DIOPT Version :9

Sequence 1:	NP_650107.1	Gene:	CG14718 / 41413	FlyBaseID:	FBgn0037939	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_010114.1	Gene:	NRP1 / 851387	SGDID:	S000002326	Length:	719	Species:	Saccharomyces cerevisiae

Alignment Length:	324	Identity:	64/324 - (19%)
Similarity:	125/324 - (38%)	Gaps:	93/324 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 LVQEDDHFC--GAEADQQLVASTSSSCPMASSGESVSIDTEQEAERDLQMNQCETLEREELNGDI 155
            |.:|.|.:|  ..|...|..|.::::|    :.:|:||:..:.. :||.    |.:...|::...
Yeast   115 LWKEFDRWCVNHPEILGQKKAISNNNC----NTKSISINAAKNT-KDLD----EIVRILEVSIPT 170

  Fly   156 GEMGEMEELAEEVNGEQRPPLLPCMGGNTSYMVFPRTAADYMPRL----ALPRH------RPYIS 210
            .|.|.:.|:                     |.:..|| .|.:.:|    ..|..      :||.|
Yeast   171 EEAGSVPEI---------------------YSLLKRT-TDILIQLHKKCTSPEDMESVLTKPYDS 213

  Fly   211 IGQEQYVIQ--AETVFVLGMRLNVTKNDIILFFGKVGV-----------------IKMDESTNKP 256
            ....:..:|  ::.:::..:..:.|::::..:|.:.||                 :..:.|.|..
Yeast   214 HTDIRAFLQEKSKILYMNNLPPDTTQSELESWFTQYGVRPVGFWTVKNIVEDTSNVNNNWSLNNS 278

  Fly   257 KIFVYKNKITG----RSKGEATITYVSPFSAQAAISCLSGAK---FMGQVITVLPAYLST----R 310
            .....::.|:|    ::..||  |.|...:.::.:|.|:..|   .:..|:.:.|:  ||    :
Yeast   279 PYVEDQDSISGFVVFQTHEEA--TEVLALNGRSILSNLANTKQPRVVEHVLELQPS--STGVLDK 339

  Fly   311 RGSVRYSYPRELNAPEHQRRQRAMKWKPAIDNWVCMLCRNSNFVWRSSCNRCQADKVVAPQNNE 374
            ...:...:|:..|             ||...:|.|..|..|||..|::|.||   ...||.|::
Yeast   340 AQEILSPFPQSKN-------------KPRPGDWNCPSCGFSNFQRRTACFRC---SFPAPSNSQ 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14718	NP_650107.1	RRM	<222..>335	CDD:223796	21/140 (15%)
		RRM_SF	223..302	CDD:302621	16/102 (16%)
		zf-RanBP	343..366	CDD:279035	10/22 (45%)
		RanBP2-type Zn finger	343..362	CDD:275375	8/18 (44%)
		zf-RanBP	397..423	CDD:295417
		RanBP2-type Zn finger	398..417	CDD:275375
NRP1	NP_010114.1	RRM_ARP_like	226..328	CDD:409886	16/103 (16%)
		zf-RanBP	355..384	CDD:395516	11/31 (35%)
		RanBP2-type Zn finger	359..378	CDD:275376	8/18 (44%)
		zf-RanBP	581..609	CDD:395516
		RanBP2-type Zn finger	585..604	CDD:275376
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341573
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930