DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14718 and fus

DIOPT Version :9

Sequence 1:	NP_650107.1	Gene:	CG14718 / 41413	FlyBaseID:	FBgn0037939	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_957377.2	Gene:	fus / 394058	ZFINID:	ZDB-GENE-040426-1010	Length:	541	Species:	Danio rerio

Alignment Length:	478	Identity:	106/478 - (22%)
Similarity:	161/478 - (33%)	Gaps:	161/478 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TNSFYAPNYSDTQQPQPQLQ---TQQQMFHANYIVGTTLGSGLGFN-FAPAPIP----QASAASG 67
            :.|:.:..||:|.||.|...   :||..:.             |:| .:||..|    .:|.:||
Zfish    82 SQSYSSGGYSNTSQPPPAQSGGYSQQSSYS-------------GYNQSSPASAPGGYSSSSQSSG 133

  Fly    68 LSPR-----GMYSDLYRYEDGSGDASGSLLLVQEDDHFCGAEADQQLVASTSSSCPMASSGESVS 127
            ...:     |.|........|.|.:.|      :...|.|:....|   |:.|.....|...:.|
Zfish   134 YGQQQQQSGGGYGGSGGQSGGYGSSGG------QSSGFGGSGGQHQ---SSQSGGGSYSPSPNYS 189

  Fly   128 IDTEQEAERDLQMNQCETLEREELNGDIGEMGEMEELAEEVNGEQRPPLLPCMGG------NTSY 186
            ....|                        ..|:..:..:....:..||:....||      :..|
Zfish   190 SPPPQ------------------------SYGQQSQYGQGGYNQDSPPMSGGGGGGGYGGQDGGY 230

  Fly   187 MV-----------FPRTAADYMPR--LALPRHRPYISIG---------------------QEQYV 217
            ..           |....|....|  ...||.|..:.:|                     |||..
Zfish   231 SQDGRGGRGRGGGFGGRGAGGFDRGGRGGPRGRGGMGMGDRGGFNKFGGPRDHGAGGPNMQEQDN 295

  Fly   218 IQAETVFVLGMRLNVTKNDIILFFGKVGVIKMDESTNKPKIFVYKNKITGRSKGEATITYVSPFS 282
            ....|:||.|:..:.|.:.:..:|.::|:||:::.|..|.|.:|.::.||:.|||||:::..|.|
Zfish   296 SDNNTIFVQGLGDDYTVDSVADYFKQIGIIKVNKKTGLPMINLYTDRETGKLKGEATVSFDDPPS 360

  Fly   283 AQAAISCLSGAKFMGQVITVLPAYLSTRR---------GSVRYSYPRELNAPEHQ---------- 328
            |:|||....|..|.|..|.|   ..:|||         |.:|..  |....|..:
Zfish   361 AKAAIDWFDGKDFNGNPIKV---SFATRRAEFGRGGSSGGMRGG--RGRGGPMGRGGFGGGRGGG 420

  Fly   329 ------------------RRQRAMKWK---PAIDNWVCMLCRNSNFVWRSSCNRCQADKVVAPQN 372
                              .:|||..||   |:        |.|.||.||:.||:|:..|   |:.
Zfish   421 GGGGGFQGNNGGGSGNGGGQQRAGDWKCSNPS--------CGNLNFSWRNECNQCKEPK---PEG 474

  Fly   373 N------EGSSWAGSREEDGAPR 389
            :      .|..:.|.|...|..|
Zfish   475 SGGGMSPMGGGFGGERGRSGFDR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14718	NP_650107.1	RRM	<222..>335	CDD:223796	41/149 (28%)
		RRM_SF	223..302	CDD:302621	29/78 (37%)
		zf-RanBP	343..366	CDD:279035	9/22 (41%)
		RanBP2-type Zn finger	343..362	CDD:275375	8/18 (44%)
		zf-RanBP	397..423	CDD:295417
		RanBP2-type Zn finger	398..417	CDD:275375
fus	NP_957377.2	RRM	<274..>388	CDD:223796	37/116 (32%)
		RRM_FUS_TAF15	297..382	CDD:240979	31/87 (36%)
		zf-RanBP	443..472	CDD:279035	14/39 (36%)
		RanBP2-type Zn finger	446..467	CDD:275375	11/28 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1995
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1539664at2759
OrthoFinder	1	1.000	-	-		FOG0002238
OrthoInspector	1	1.000	-	-		otm25218
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23238
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.880