DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14718 and ewsr1b

DIOPT Version :9

Sequence 1:	NP_650107.1	Gene:	CG14718 / 41413	FlyBaseID:	FBgn0037939	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_005165164.2	Gene:	ewsr1b / 322880	ZFINID:	ZDB-GENE-030131-1600	Length:	579	Species:	Danio rerio

Alignment Length:	467	Identity:	103/467 - (22%)
Similarity:	166/467 - (35%)	Gaps:	130/467 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PQPQLQTQ-QQMFHANYIVGTT--------LGSGLGFNFAP----------APIPQASAASG--- 67
            |||...|| .|.:.|:...|:|        .||..|::..|          |..||:.:||.
Zfish    93 PQPGAYTQPAQSYGASSYTGSTAAPAAQASYGSQPGYSTQPAYSGYSQQPAASAPQSYSASSQPA 157

  Fly    68 ------LSPRGMYSDLYR-YEDGSGDASGSLLLVQEDDHFCGAEADQQLVASTSSSCPMASSGES 125
                  ..|.|.....|: .:.|.|..       |:..:..|....|......::..|..||..:
Zfish   158 YNQSAYSQPAGYSQPGYQAQQPGYGQQ-------QQSAYGQGQPPQQHQQGPPAAYPPQGSSSYA 215

  Fly   126 VSIDTEQEA-ERDLQMNQCETLEREELNGDI----------------------------GEMGEM 161
            .:...:|.| :.|.|.|...:..:..::|..                            |.||
Zfish   216 QTQYGQQSAPQNDYQQNPYNSYSQGGVSGGYPGSQRGGYQDGGRDGYDRGGPRGRGMGRGGMG-- 278

  Fly   162 EELAEEVNGEQRPPLLPCMGGNTSYMVFPRTAADYMPRLALPRHRPYISIGQEQYVIQAETVFVL 226
              :|.:..|..:|. .|..||....|..|                     |::.  .:..|:::.
Zfish   279 --IAGDRGGFNKPG-GPMRGGMDRDMGHP---------------------GEQD--SENSTIYIT 317

  Fly   227 GMRLNVTKNDIILFFGKVGVIKMDESTNKPKIFVYKNKITGRSKGEATITYVSPFSAQAAISCLS 291
            |:..|.|..::..||...|.|:::...|:|.|.:|.:|.:|:.||:||::|..|..|:||:....
Zfish   318 GLTENATLPEMAEFFKHTGAIRINRRLNQPAINIYTDKDSGKPKGDATLSYEEPAFAKAAVEHFD 382

  Fly   292 GAKFMGQVITVLPAYLSTRRGSVRYSYPRELNAPEHQRRQRAMKWKPAIDNWVCMLCR---NSNF 353
            |.:|.|:.:.|..|......|.:|...|              |:..|.:|.. .|:.|   ...|
Zfish   383 GKEFQGRRLKVSMARRKPMIGGMRGGMP--------------MRGGPGMDRG-GMMGRGGERGGF 432

  Fly   354 VWRSSCNRCQADKVVAPQNNEGSSWAGSREEDGAPRRWRPYRNDWLCKI--CYNMNFWYRAKCNR 416
            ..|.           .|:.  |..|.|..:.....:|    ..||.|..  |.|.||.:|.:||:
Zfish   433 PPRG-----------GPRG--GMGWNGGPQPGNVQKR----AGDWECPNAGCGNQNFSWRMECNQ 480

  Fly   417 CHALRSDEMKSS 428
            |.|.:.:.:.:|
Zfish   481 CKAPKPEGLGTS 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14718	NP_650107.1	RRM	<222..>335	CDD:223796	31/112 (28%)
		RRM_SF	223..302	CDD:302621	25/78 (32%)
		zf-RanBP	343..366	CDD:279035	4/25 (16%)
		RanBP2-type Zn finger	343..362	CDD:275375	4/21 (19%)
		zf-RanBP	397..423	CDD:295417	12/27 (44%)
		RanBP2-type Zn finger	398..417	CDD:275375	9/20 (45%)
ewsr1b	XP_005165164.2	RRM	<306..>397	CDD:223796	27/92 (29%)
		RRM_SF	312..395	CDD:302621	27/82 (33%)
		zf-RanBP	456..486	CDD:279035	13/33 (39%)
		RanBP2-type Zn finger	460..481	CDD:275375	9/20 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1995
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1539664at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25218
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23238
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.880