DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG14718 and Fus

DIOPT Version :9

Sequence 1:NP_650107.1 Gene:CG14718 / 41413 FlyBaseID:FBgn0037939 Length:446 Species:Drosophila melanogaster
Sequence 2:NP_631888.1 Gene:Fus / 233908 MGIID:1353633 Length:518 Species:Mus musculus


Alignment Length:473 Identity:113/473 - (23%)
Similarity:158/473 - (33%) Gaps:144/473 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 YTNSFYAPNYSDTQQPQPQLQTQQQMFHANYIVGTTLGSGL---------------GFNFAPAPI 59
            |..|.|..:|..||......|:..|.:      |:|.|.|.               |:...|||.
Mouse    50 YGQSSYGSSYGQTQNTGYGTQSAPQGY------GSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPS 108

  Fly    60 PQASAASGLSPRGMY----SDLYRYEDGSGDASGSLLLVQEDDHFCGAEA-DQQLVASTSSSCPM 119
            ..:.:..|.|....|    |..|..:.|.|....|  ..|:...:...:. .||...::||....
Mouse   109 STSGSYGGSSQSSSYGQPQSGGYGQQSGYGGQQQS--YGQQQSSYNPPQGYGQQNQYNSSSGGGG 171

  Fly   120 ASSGESVSIDTEQEAERDLQMNQCETLEREELNGDIGEMGEMEELA----------EEVNGEQRP 174
            ...|.:...|....:.                .|..|..|..::..          ::..|..| 
Mouse   172 GGGGGNYGQDQSSMSG----------------GGGGGGYGNQDQSGGGGGGYGGGQQDRGGRGR- 219

  Fly   175 PLLPCMGGNTSYMVFPRTAADYMPR----------------------LALP-----RHRPYISIG 212
                  ||...|   .|::..|.||                      ...|     ||      .
Mouse   220 ------GGGGGY---NRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRH------D 269

  Fly   213 QEQYVIQAETVFVLGMRLNVTKNDIILFFGKVGVIKMDESTNKPKIFVYKNKITGRSKGEATITY 277
            .||......|:||.|:..|||...:..:|.::|:||.::.|.:|.|.:|.::.||:.|||||:::
Mouse   270 SEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSF 334

  Fly   278 VSPFSAQAAISCLSGAKFMGQVITVLPAYLSTRR------------------------------- 311
            ..|.||:|||....|.:|.|..|.|   ..:|||                               
Mouse   335 DDPPSAKAAIDWFDGKEFSGNPIKV---SFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSG 396

  Fly   312 GSVRYSYPRELNAPEHQRRQRAMKWKPAIDNWVC--MLCRNSNFVWRSSCNRCQADKVVAPQNNE 374
            |..|..:|........|  |||..||       |  ..|.|.||.||:.||:|:|.|...|....
Mouse   397 GGGRGGFPSGGGGGGGQ--QRAGDWK-------CPNPTCENMNFSWRNECNQCKAPKPDGPGGGP 452

  Fly   375 GSSWAGSREEDGAPRRWR 392
            |.|..|...  |..||.|
Mouse   453 GGSHMGGNY--GDDRRGR 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14718NP_650107.1 RRM <222..>335 CDD:223796 43/143 (30%)
RRM_SF 223..302 CDD:302621 31/78 (40%)
zf-RanBP 343..366 CDD:279035 11/24 (46%)
RanBP2-type Zn finger 343..362 CDD:275375 9/20 (45%)
zf-RanBP 397..423 CDD:295417
RanBP2-type Zn finger 398..417 CDD:275375
FusNP_631888.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..279 48/268 (18%)
RRM <257..>367 CDD:223796 41/118 (35%)
RRM_FUS_TAF15 276..361 CDD:240979 33/87 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 368..417 6/50 (12%)
zf-RanBP 415..442 CDD:279035 14/33 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 437..518 13/34 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1995
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002238
OrthoInspector 1 1.000 - - otm44163
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23238
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
65.870

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