DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14718 and Ewsr1

DIOPT Version :9

Sequence 1:	NP_650107.1	Gene:	CG14718 / 41413	FlyBaseID:	FBgn0037939	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_006514571.1	Gene:	Ewsr1 / 14030	MGIID:	99960	Length:	668	Species:	Mus musculus

Alignment Length:	490	Identity:	111/490 - (22%)
Similarity:	164/490 - (33%)	Gaps:	166/490 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSTSASVVYTNSFYA-----------PNY------------------SDTQQP--------QPQL 29
            |||:|:|..|.:.||           |.|                  ::|.||        ||.|
Mouse   105 DSTTATVTTTQASYAAQTAYGTQPAYPTYGQQPTATAPTRPQDGNKPAETSQPQSSTGGYNQPSL 169

  Fly    30 QTQQQMFHANYIVGTTLGSGLGFNFAPAPIPQA---SAASGLSPRGMYSDLYRYEDGSGDASGSL 91
            ...|    :||......||   :...|...|.:   ::.|...|.......|..::..|..|.
Mouse   170 GYGQ----SNYSYPQVPGS---YPMQPVTAPPSYPPTSYSSSQPTSYDQSSYSQQNTYGQPSS-- 225

  Fly    92 LLVQEDDHFCGAEADQQLVAS------TSSSCPMASSGESVSIDTEQEAERDLQMNQCETLEREE 150
             ..|:..:...:...||...|      :.|..|...|.:|.|...:....:|...:.  .:..:|
Mouse   226 -YGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQDHPSSM--GVYGQE 287

  Fly   151 LNGDIGEMGEMEELAEEVN----------------------------GEQRPPLLPCMGGNTSYM 187
            ..|..|. ||...|:...|                            ||:        ||...
Mouse   288 SGGFSGP-GENRSLSGPDNRGRGRGGFDRGGMSRGGRGGGRGGLGSAGER--------GGFNK-- 341

  Fly   188 VFPRTAADYMP--RLALPRHRPYISIGQEQYVIQAETVFVLGMRLNVTKNDIILFFGKVGVIKMD 250
              |....|..|  .|.||     |...::.   ....::|.|:..|||.:|:..||.:.||:||:
Mouse   342 --PGGPMDEGPDLDLGLP-----IDPDEDS---DNSAIYVQGLNDNVTLDDLADFFKQCGVVKMN 396

  Fly   251 ESTNKPKIFVYKNKITGRSKGEATITYVSPFSAQAAISCLSGAKFMGQVITV-----LPAYLSTR 310
            :.|.:|.|.:|.:|.||:.||:||::|..|.:|:||:....|..|.|..:.|     .|...|.|
Mouse   397 KRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSMR 461

  Fly   311 ----------------------------------RGSVRYSYPRELNAPEHQRRQRAMKWKPA-- 339
                                              ||..|..:|        .|..|..:..|:
Mouse   462 GGMPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFP--------PRGPRGSRGNPSGG 518

  Fly   340 ------IDNWVCML--CRNSNFVWRSSCNRCQADK 366
                  ..:|.|..  |.|.||.||:.||:|:|.|
Mouse   519 GNVQHRAGDWQCPNPGCGNQNFAWRTECNQCKAPK 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14718	NP_650107.1	RRM	<222..>335	CDD:223796	41/151 (27%)
		RRM_SF	223..302	CDD:302621	31/78 (40%)
		zf-RanBP	343..366	CDD:279035	12/24 (50%)
		RanBP2-type Zn finger	343..362	CDD:275375	10/20 (50%)
		zf-RanBP	397..423	CDD:295417
		RanBP2-type Zn finger	398..417	CDD:275375
Ewsr1	XP_006514571.1	PRK12438	<52..159	CDD:171499	13/53 (25%)
		RRM_EWS	367..450	CDD:240977	32/82 (39%)
		zf-RanBP	525..553	CDD:366216	12/27 (44%)
		RanBP2-type Zn finger	528..549	CDD:275375	10/20 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1995
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2798
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1539664at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23238
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.830