DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14717 and ABHD11

DIOPT Version :9

Sequence 1:	NP_001262481.1	Gene:	CG14717 / 41412	FlyBaseID:	FBgn0265271	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	XP_024302717.1	Gene:	ABHD11 / 83451	HGNCID:	16407	Length:	434	Species:	Homo sapiens

Alignment Length:	244	Identity:	75/244 - (30%)
Similarity:	115/244 - (47%)	Gaps:	21/244 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SLESWRQVAVNLSQVGLRQVITVDARNHGLSPYITGHSPMHLAADVEALMSHQRLNKIVALGHGM 121
            ||..|            .||:||||||||.||:....|...::.|::.|:....|...|.:||.|
Human   209 SLAEW------------PQVLTVDARNHGDSPHSPDMSYEIMSQDLQDLLPQLGLVPCVVVGHSM 261

  Fly   122 GGRAMMTLALTQPQLVERVILVDITPAPVPSNFYLTRQVFEMMLQVAPSIPSNLSLSEGRTFILP 186
            ||:..|.|||.:|:||||:|.|||:|.......:....|..|.   |.:|...|..|..|.....
Human   262 GGKTAMLLALQRPELVERLIAVDISPVESTGVSHFATYVAAMR---AINIADELPRSRARKLADE 323

  Fly   187 LFQDVVHDASELRRIIYNLRKMQDNTFGWAVNPQAVLSSWGEMMINYEATLGGLRPYMGEVLLIA 251
            ....|:.|.:..:.::.||.:: |..|.|.||..|:.....:::    |.......|:|..|.:.
Human   324 QLSSVIQDMAVRQHLLTNLVEV-DGRFVWRVNLDALTQHLDKIL----AFPQRQESYLGPTLFLL 383

  Fly   252 GSQSEFVTTTSIAVMQRYFPNTVVQ-ILDAGHCVYEDQPEQFVELVVEF 299
            |..|:||..:....:.|.||...:| :.:|||.::.|:|:.|:..:..|
Human   384 GGNSQFVHPSHHPEIMRLFPRAQMQTVPNAGHWIHADRPQDFIAAIRGF 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14717	NP_001262481.1	MhpC	28..299	CDD:223669	74/242 (31%)
		Abhydrolase_5	47..>165	CDD:289465	41/107 (38%)
		Abhydrolase	<249..301	CDD:304388	15/52 (29%)
ABHD11	XP_024302717.1	Atrophin-1	<15..159	CDD:331285
ABHD11	XP_024302717.1	PRK10673	216..433	CDD:331147	71/225 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155468
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2382
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62887
OrthoDB	1	1.010	-	-		D1268438at2759
OrthoFinder	1	1.000	-	-		FOG0001908
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1622
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.720