DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14717 and Ephx2

DIOPT Version :9

Sequence 1:	NP_001262481.1	Gene:	CG14717 / 41412	FlyBaseID:	FBgn0265271	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_075225.1	Gene:	Ephx2 / 65030	RGDID:	620732	Length:	554	Species:	Rattus norvegicus

Alignment Length:	317	Identity:	62/317 - (19%)
Similarity:	122/317 - (38%)	Gaps:	60/317 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GTRLEYVSYTSPRNQMQAPPIVVMHDLNLSLESWRQVAVNLSQVGLRQVITVDARNHGLS---PY 89
            |.||.:|...|      .|.|.:.|....|..|||.....|:|.|.| |:.:|.:.:|.|   |.
  Rat   245 GIRLHFVEMGS------GPAICLCHGFPESWFSWRYQIPALAQAGFR-VLAIDMKGYGDSSSPPE 302

  Fly    90 ITGHSPMHLAADVEALMSHQRLNKIVALGHGMGGRAMMTLALTQPQLVERVILVD---ITPAPVP 151
            |..::...|..::...::...:.:.|.:||...|..:..:||..|:.|..|..::   :.|.|..
  Rat   303 IEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPLMPPNPEV 367

  Fly   152 SNFYLTRQV----FEMMLQVAPSIPSNLSLSEGRTFILPLFQD-------VVHDASELRRII--- 202
            |...:.|.:    :::..|......:.|..:..||| ...|:.       .|:.|:|:..|:
  Rat   368 SPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTF-KSFFRTSDDMGLLTVNKATEMGGILVGT 431

  Fly   203 ----------------YNLRKMQDNTF----GWAVNPQAVLSSWGEMMINYEATLGGL-RPYMGE 246
                            |.:::.:.:.|    .|..|.:.          |::.:...| |..:..
  Rat   432 PEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTER----------NWKWSCKALGRKILVP 486

  Fly   247 VLLIAGSQSEFVTTTSIAVMQRYFPNTV-VQILDAGHCVYEDQPEQFVELVVEFTQT 302
            .|::...:...:.......|:.:.|... ..|.|.||....::|.:..::::::.:|
  Rat   487 ALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKWLKT 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14717	NP_001262481.1	MhpC	28..299	CDD:223669	61/312 (20%)
		Abhydrolase_5	47..>165	CDD:289465	30/127 (24%)
		Abhydrolase	<249..301	CDD:304388	7/52 (13%)
Ephx2	NP_075225.1	Phosphatase	1..224
		HAD-SF-IA-v3	5..203	CDD:273662
		Phosphate binding. /evidence=ECO:0000250\|UniProtKB:P34913	123..124
		HAD_like	<142..205	CDD:304363
		Epoxide hydrolase	233..554		62/317 (20%)
		Abhydrolase	239..>379	CDD:304388	36/140 (26%)
		Abhydrolase_1	257..530	CDD:278959	55/284 (19%)
		Microbody targeting signal. /evidence=ECO:0000255	552..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910