DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MARS1 and GstD10

DIOPT Version :9

Sequence 1:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens
Sequence 2:	NP_001287302.1	Gene:	GstD10 / 59240	FlyBaseID:	FBgn0042206	Length:	210	Species:	Drosophila melanogaster

Alignment Length:	165	Identity:	46/165 - (27%)
Similarity:	68/165 - (41%)	Gaps:	26/165 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRLFVSDGVPGCLPVLAAAGRARG---RAEVLISTVGPEDCVVPFL-TRPK--VPVLQLDSGNYL 59
            |.|:...|...|..||..| :|.|   ..:.:|:|...|.....:| ..|:  :|.|. |.|..|
  Fly     1 MDLYYRPGSAPCRSVLMTA-KALGVEFDKKTIINTRAREQFTPEYLKINPQHTIPTLH-DHGFAL 63

Human    60 FSTSAICRYFFLLSGWEQDD-----------LTNQWLEWEATELQPALSAALYYLVVQGKK--GE 111
            :.:.||..|  |:..:.:||           |.||.|.::...|..:.| ..||..:..||  .|
  Fly    64 WESRAIMVY--LVEKYGKDDKLFPKDVQKQALINQRLYFDMGTLYKSFS-EYYYPQIFLKKPANE 125

Human   112 DVLGSVRRALTHIDHSLSRQNCPFLAGETESLADI 146
            :....:..|...::..|..|.  :.||...|||||
  Fly   126 ENYKKIEVAFEFLNTFLEGQT--YSAGGDYSLADI 158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274	12/43 (28%)
		GstA	<47..189	CDD:223698	32/115 (28%)
		GST_C_MetRS_N	77..179	CDD:198340	23/83 (28%)
		PRK12268	264..819	CDD:237029
		MetRS_core	265..633	CDD:173907
		'HIGH' region	273..283
		'KMSKS' region	593..597
		Anticodon_Ia_Met	642..771	CDD:153411
		MetRS_RNA	845..889	CDD:238475
GstD10	NP_001287302.1	GST_N_Delta_Epsilon	1..75	CDD:239343	23/77 (30%)
		PLN02473	3..196	CDD:166114	45/163 (28%)
		GST_C_Delta_Epsilon	89..205	CDD:198287	21/73 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900