DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MARS1 and GstD5

DIOPT Version :9

Sequence 1:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens
Sequence 2:	NP_524914.3	Gene:	GstD5 / 48338	FlyBaseID:	FBgn0010041	Length:	216	Species:	Drosophila melanogaster

Alignment Length:	164	Identity:	39/164 - (23%)
Similarity:	73/164 - (44%)	Gaps:	21/164 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRLFVSDGVPGCLPVLAAAGRARGRAEV-LISTVGPEDCVVPFL-TRPK--VPVLQLDSGNYLFS 61
            |..:.|....||..|:..|.....:..: |::|:..:.....|: ..|:  :|.| :|:|..::.
  Fly     1 MDFYYSPRGSGCRTVIMVAKALGVKLNMKLLNTLEKDQLKPEFVKLNPQHTIPTL-VDNGFSIWE 64

Human    62 TSAICRYFFLLSGWEQDD-----------LTNQWLEWEATELQPALSAALYYLVVQGKKGEDV-L 114
            :.||..|  |:..:.:||           |.||.|.::...|..:.:...|.|...||.|.|. .
  Fly    65 SRAIAVY--LVEKYGKDDTLFPKDPKKQALVNQRLYFDMGTLYDSFAKYYYPLFHTGKPGSDEDF 127

Human   115 GSVRRALTHIDHSLSRQNCPFLAGETESLADIVL 148
            ..:..:..:::..|..||  ::||:..::|||.:
  Fly   128 KKIESSFEYLNIFLEGQN--YVAGDHLTVADIAI 159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274	10/44 (23%)
		GstA	<47..189	CDD:223698	29/116 (25%)
		GST_C_MetRS_N	77..179	CDD:198340	21/84 (25%)
		PRK12268	264..819	CDD:237029
		MetRS_core	265..633	CDD:173907
		'HIGH' region	273..283
		'KMSKS' region	593..597
		Anticodon_Ia_Met	642..771	CDD:153411
		MetRS_RNA	845..889	CDD:238475
GstD5	NP_524914.3	GstA	1..184	CDD:223698	39/164 (24%)
		GST_N_Delta_Epsilon	1..74	CDD:239343	18/75 (24%)
		GST_C_Delta_Epsilon	88..204	CDD:198287	19/74 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810