DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MARS1 and GstD11

DIOPT Version :9

Sequence 1:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens
Sequence 2:	NP_001138040.1	Gene:	GstD11 / 41512	FlyBaseID:	FBgn0038029	Length:	243	Species:	Drosophila melanogaster

Alignment Length:	137	Identity:	30/137 - (21%)
Similarity:	55/137 - (40%)	Gaps:	44/137 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    33 VGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDD-----------LTNQWLE 86
            :.|:.|         ||.:. |.|..|:.:.||..|  |::.:.:.|           |.:|.|:
  Fly    70 MNPQHC---------VPTMN-DEGLVLWESRAILSY--LVAAYGKSDQLYPTDIRVRALVDQRLQ 122

Human    87 WEATELQPALSAALYYL--------VVQGKKGE--DVLGSVRRALTHIDHSLSRQNCPFLAGETE 141
            ::...|...|:.  ||.        :.:||:.:  :.:|.:...|.      .||   |.|.:..
  Fly   123 FDLGTLYMRLTD--YYFPTMFIGAPLDEGKRAKLAEAVGWLNTILE------GRQ---FSAADHF 176

Human   142 SLADIVL 148
            ::||:.|
  Fly   177 TIADLTL 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274	9/34 (26%)
		GstA	<47..189	CDD:223698	28/123 (23%)
		GST_C_MetRS_N	77..179	CDD:198340	19/93 (20%)
		PRK12268	264..819	CDD:237029
		MetRS_core	265..633	CDD:173907
		'HIGH' region	273..283
		'KMSKS' region	593..597
		Anticodon_Ia_Met	642..771	CDD:153411
		MetRS_RNA	845..889	CDD:238475
GstD11	NP_001138040.1	GST_N_Delta_Epsilon	25..98	CDD:239343	11/39 (28%)
GstD11	NP_001138040.1	GST_C_Delta_Epsilon	112..231	CDD:198287	18/83 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900