DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MARS1 and GstD9

DIOPT Version :9

Sequence 1:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens
Sequence 2:	NP_001287303.1	Gene:	GstD9 / 41502	FlyBaseID:	FBgn0038020	Length:	218	Species:	Drosophila melanogaster

Alignment Length:	191	Identity:	47/191 - (24%)
Similarity:	68/191 - (35%)	Gaps:	51/191 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   546 VDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDT 610
            :|.|..:.  :.|..|::....|||.|.|...|. |.|.|:|..|..|.:....:...    .|.
  Fly     2 LDFYYMLY--SAPCRSILMTARALGLELNKKQVD-LDAGEHLKPEFVKINPQHTIPTL----VDD 59

Human   611 GIPADIW--RFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF-VSKFFGGYVPEM 672
            |..  ||  |..|:|: .|..|...|   |..|:..:..     .||:...| :|..:..||
  Fly    60 GFA--IWESRAILIYL-AEKYDKDGS---LYPKDPQQRA-----VINQRLFFDLSTLYQSYV--- 110

Human   673 VLTPDDQRLLAHVTLELQHYHQLLEKV----------RIRDALRSILTISRHGNQYIQVNE 723
                            ..:|.||.|.|          :|.||.....|:.: |.||..:|:
  Fly   111 ----------------YYYYPQLFEDVKKPADPDNLKKIDDAFAMFNTLLK-GQQYAALNK 154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274
		GstA	<47..189	CDD:223698
		GST_C_MetRS_N	77..179	CDD:198340
		PRK12268	264..819	CDD:237029	47/191 (25%)
		MetRS_core	265..633	CDD:173907	25/88 (28%)
		'HIGH' region	273..283
		'KMSKS' region	593..597		1/3 (33%)
		Anticodon_Ia_Met	642..771	CDD:153411	19/93 (20%)
		MetRS_RNA	845..889	CDD:238475
GstD9	NP_001287303.1	GST_N_Delta_Epsilon	2..75	CDD:239343	23/82 (28%)
		GstA	4..187	CDD:223698	46/189 (24%)
		GST_C_Delta_Epsilon	89..207	CDD:198287	19/91 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900