DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MARS1 and GstE11

DIOPT Version :9

Sequence 1:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens
Sequence 2:	NP_001286575.1	Gene:	GstE11 / 37128	FlyBaseID:	FBgn0034354	Length:	225	Species:	Drosophila melanogaster

Alignment Length:	226	Identity:	47/226 - (20%)
Similarity:	83/226 - (36%)	Gaps:	48/226 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     3 LFVSDGVPGCLPVLAAAGRARGRAEV-LISTVGPEDCVVPFL---TRPKVPVLQLDSGNYLFSTS 63
            |:.:...|.|..||..|.......:: |::....|.....||   .:..:|||. |:|..:..:.
  Fly     7 LYYAPRSPPCRAVLLTAAALGLELDLRLVNVKAGEHKSAEFLKLNAQHTIPVLD-DNGTIVSDSH 70

Human    64 AICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYY----------LVVQ-------GKKGE 111
            .||.|.......|.||.    |..:..|.:..:.|.|||          .:|:       |:...
  Fly    71 IICSYLADKYAPEGDDS----LYPKDPEKRRLVDARLYYDCGHLFPRIRFIVEPVIYFGAGEVPS 131

Human   112 DVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTL 176
            |.:..:::|...::|.|:..:  :|.|:..::||:....::..........|::...|..|.:.:
  Fly   132 DRVAYLQKAYDGLEHCLAEGD--YLVGDKLTIADLSCIASVSTAEAFAPIEPDQFPRLVQWVKRI 194

Human   177 STQEPCQRAAETVLKQQGVLALRPYLQKQPQ 207
            .                   || ||.||..|
  Fly   195 Q-------------------AL-PYYQKNNQ 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274	11/44 (25%)
		GstA	<47..189	CDD:223698	30/158 (19%)
		GST_C_MetRS_N	77..179	CDD:198340	21/118 (18%)
		PRK12268	264..819	CDD:237029
		MetRS_core	265..633	CDD:173907
		'HIGH' region	273..283
		'KMSKS' region	593..597
		Anticodon_Ia_Met	642..771	CDD:153411
		MetRS_RNA	845..889	CDD:238475
GstE11	NP_001286575.1	GstA	5..198	CDD:223698	42/217 (19%)
		GST_N_Delta_Epsilon	5..78	CDD:239343	18/71 (25%)
		GST_C_Delta_Epsilon	94..211	CDD:198287	25/134 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900