DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MARS1 and GstE7

DIOPT Version :9

Sequence 1:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens
Sequence 2:	NP_611329.1	Gene:	GstE7 / 37112	FlyBaseID:	FBgn0063493	Length:	223	Species:	Drosophila melanogaster

Alignment Length:	232	Identity:	48/232 - (20%)
Similarity:	83/232 - (35%)	Gaps:	78/232 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    28 VLISTVGPEDCVVPFLTR-PK--VPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEA 89
            |.::|...|:....||.: |:  ||.|: |.|:|::.:.||..|  |:|.:.:.|
  Fly    32 VEVNTRAKENFSEEFLKKNPQHTVPTLE-DDGHYIWDSHAIIAY--LVSKYGKTD---------- 83

Human    90 TELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYP 154
                     :||        .:|:|   :||:  :|..|..::....|....|:...:..|.
  Fly    84 ---------SLY--------PKDLL---QRAV--VDQRLHFESGVIFANALRSITKPLFAGK--- 123

Human   155 LLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNE 219
                               ||:..:|......|.....:..||...|:         .|..:| .
  Fly   124 -------------------QTMIPKERYDAIIEVYDFLEKFLAGNDYV---------AGNQLT-I 159

Human   220 PEEEELATLSEEEIAMAV--------TAWEKGLESLP 248
            .:...::|:|..|:.:.|        .||.|.|:.||
  Fly   160 ADFSIISTVSSLEVFVKVDTTKYPRIAAWFKRLQKLP 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274	14/42 (33%)
		GstA	<47..189	CDD:223698	27/143 (19%)
		GST_C_MetRS_N	77..179	CDD:198340	14/101 (14%)
		PRK12268	264..819	CDD:237029
		MetRS_core	265..633	CDD:173907
		'HIGH' region	273..283
		'KMSKS' region	593..597
		Anticodon_Ia_Met	642..771	CDD:153411
		MetRS_RNA	845..889	CDD:238475
GstE7	NP_611329.1	GstA	4..196	CDD:223698	46/230 (20%)
		GST_N_Delta_Epsilon	4..77	CDD:239343	16/47 (34%)
		GST_C_Delta_Epsilon	91..209	CDD:198287	27/143 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810