Protein Alignment MARS1 and Mars1

DIOPT Version :10

• Sequence 1: NP_004981.2
• Gene: MARS1 / 4141
• HGNCID: 6898
• Length: 900
• Species: Homo sapiens
• Sequence 2: XP_006241513.1
• Gene: Mars1 / 299851
• RGDID: 1305321
• Length: 910
• Species: Rattus norvegicus
• Alignment Length: 910
• Identity: 819/910 - (90%)
• Similarity: 854/910 - (93%)
• Gaps: 10/910 - (1%)

Human     1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAI 65
            ||||||:|.||.|||||||.|||||||:||||||||:||||||||||||||||||||||||.|||
  Rat     1 MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGPEECVVPFLTRPKVPVLQLDSGNYLFSASAI 65

Human    66 CRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSR 130
            |||||||.|||||||||||||||||||||.||||||.|||||||||||||.:||.||||||||||
  Rat    66 CRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALYCLVVQGKKGEDVLGPLRRVLTHIDHSLSR 130

Human   131 QNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGV 195
            ||||||||:|||||||||||||||||||||||||||.||.|||||||||||||||||||||||||
  Rat   131 QNCPFLAGDTESLADIVLWGALYPLLQDPAYLPEELGALQSWFQTLSTQEPCQRAAETVLKQQGV 195

Human   196 LALRPYLQKQPQPS--PAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVL 258
            |||||||||||||.  |.|||||:||||||||||||||:|..||.|||||||:||||:|||:|||
  Rat   196 LALRPYLQKQPQPQPLPPEGRAVSNEPEEEELATLSEEDIIAAVAAWEKGLENLPPLQPQQHPVL 260

Human   259 PVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKAL 323
            ||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
  Rat   261 PVPGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKAM 325

Human   324 EEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLR 388
            ||||||||||||||.||.|||||||||||.|||||||.||||||||||:||.|||||||||||||
  Rat   326 EEGLTPQEICDKYHAIHVDIYRWFNISFDTFGRTTTPLQTKITQDIFQRLLTRGFVLQDTVEQLR 390

Human   389 CEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLD 453
            ||.||||||||||||||||||||||||||||||||||||:|||:||||||||.|||:||:|||||
  Rat   391 CEQCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAIELKRPQCKVCRSHPVVKSSKHLFLD 455

Human   454 LPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVW 518
            |||||||||:|||:|:|||||||||:||.||||||||||||||||||||||||||||||||||||
  Rat   456 LPKLEKRLEDWLGKTMPGSDWTPNARFIIRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVW 520

Human   519 FDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIA 583
            ||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||.:|||
  Rat   521 FDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHGLVFPCSALGAEDNYTLVKNLIA 585

Human   584 TEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLN 648
            ||||||||||||||||:|||||||||||||||||||||||||||||||||||||||:||||||||
  Rat   586 TEYLNYEDGKFSKSRGIGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLIKNNSELLN 650

Human   649 NLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISR 713
            |||||||||||||||||||.|||||||.||:||:|||:.|||.||||||||||||||||||||||
  Rat   651 NLGNFINRAGMFVSKFFGGCVPEMVLTHDDRRLVAHVSWELQRYHQLLEKVRIRDALRSILTISR 715

Human   714 HGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPAC 778
            |||||||||||||||||.|.||||||||||:||||||||||||||||||||:|||.|||||..||
  Rat   716 HGNQYIQVNEPWKRIKGDEMDRQRAGTVTGMAVNIAALLSVMLQPYMPTVSSTIQTQLQLPEAAC 780

Human   779 SILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGG--------QAKTSPKPAVVETVT 835
            .||.|:|:|||||||:|||||||||||||||||:||||||||        |||.||||||||.||
  Rat   781 RILATSFICTLPAGHRIGTVSPLFQKLENDQIENLRQRFGGGQLEESLELQAKGSPKPAVVEAVT 845

Human   836 TAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 900
            ||..|.||.|:|||||||||||||||||||||:||||||||||||||||:|||||.|.|||||||
  Rat   846 TAGSQDIQVLVDEVTKQGNIVRELKAQKADKNQVAAEVAKLLDLKKQLALAEGKPIETPKGKKKK 910

Human   901  900
              Rat   911  910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARS1	NP_004981.2	GST_N_5	1..74	CDD:436537	65/72 (90%)
		GST_C_MetRS_N	77..179	CDD:198340	93/101 (92%)
		PLN02610	251..893	CDD:215329	585/649 (90%)
		'HIGH' region	273..283		9/9 (100%)
		'KMSKS' region	593..597		3/3 (100%)
Mars1	XP_006241513.1	GST_N_5	1..74	CDD:436537	65/72 (90%)
		GST_C_MetRS_N	77..179	CDD:198340	93/101 (92%)
		PLN02610	258..>839	CDD:215329	527/580 (91%)
		MetRS_RNA	855..899	CDD:238475	40/43 (93%)