DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6834 and CG5644

DIOPT Version :9

Sequence 1:	NP_650104.2	Gene:	CG6834 / 41409	FlyBaseID:	FBgn0037935	Length:	895	Species:	Drosophila melanogaster
Sequence 2:	NP_648274.1	Gene:	CG5644 / 39029	FlyBaseID:	FBgn0035948	Length:	459	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	109/472 - (23%)
Similarity:	181/472 - (38%)	Gaps:	119/472 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QFEELLAAHVDQF---SKIVGFQV-----KPAMAPGENYATLMLRISI-------DVELTDKSTK 118
            |:|| .|.|:.|.   ||:|.|.:     ....:.|:||.:::.|::|       |.||.  .::
  Fly    31 QYEE-NAEHLRQLFSQSKLVSFSIAHIACSAGSSSGDNYMSVVKRVTISQAGKDQDPELA--GSE 92

  Fly   119 LVCFMLKVPHNVPQMEQMLAMANFFNSENKVYSDILPKL-----EELYK----AKGLDITFAPKA 174
            :|..::|.........|:......|::|...|..:.|.|     .:|:.    |:..|...|...
  Fly    93 IVTVIVKRQIASLSRRQLYRCEEAFSNEINAYRHLAPLLAAHSRHQLFPVCHIAESQDRRDAEGG 157

  Fly   175 FKLDSVKEPKLANTVLMSDLSQDGFKNLNRLECLNLEQTKFALKKLAQFHAASSMNVQVNGP--- 236
                   ||    .:::.||...||:..:||..|.|......:|||||.||||....::...
  Fly   158 -------EP----IIVLQDLKAMGFRMKDRLAGLELSDCLLVMKKLAQLHAASLAAQELESSSFA 211

  Fly   237 ----------YED---------------QFVNGVMGGNKEVLMAFYEGMVASFRTALMANLKNFK 276
                      |.|               |.:..:...|.:..:.....::...||.|..|||:..
  Fly   212 FHADHLQEIVYCDEATDFYATILDTSVQQALESLGDANADDCLTTPIRLLEELRTNLFENLKHEI 276

  Fly   277 NGEEFREKLEKAFVQIFLDFEHLMTADPDEFNVLNHGDCWMNNLLFKLDSKGEVQDMLFVDFQNP 341
            |.                     ..|.|:  :|:.|||.|:||::|    :.|.::::|.|.|..
  Fly   277 NA---------------------TAAAPN--SVICHGDLWVNNIMF----RSEPEEVIFFDLQAM 314

  Fly   342 KYGSPTQDLFYLILTS-------VHIDYKLDYFEYF----IRHYHEQLT--QHLDLL--GFTGKQ 391
            :..||..|:.:.|.||       ||.|..|..:...    :||..|..|  :.|:.|  .|:.::
  Fly   315 RKSSPIFDILHFIYTSTRRPLRDVHTDTLLAAYSQALSEELRHQLEDTTAAERLEELCEAFSLQR 379

  Fly   392 PS---LRELHMLMYKHGSWAVFPSIGVLPIVLLDPNESATFENFLGDSESSAKFKNLLYTNKRYH 453
            .|   :|::|..: ..|.|       :||.|..|||.....:.....:.:..:.|........||
  Fly   380 LSSDYVRQVHYGL-AIGMW-------ILPAVTFDPNNLPNLDVMSEQNLTGKEIKCTQMLTSEYH 436

  Fly   454 GYIEKLLPWLDNKGFLE 470
            ..|.:|:......|:|:
  Fly   437 MRIRELVMEFYELGYLQ 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6834	NP_650104.2	EcKinase	95..387	CDD:281023	80/350 (23%)
CG6834	NP_650104.2	EcKinase	529..813	CDD:281023
CG5644	NP_648274.1	EcKinase	65..357	CDD:281023	74/331 (22%)
CG5644	NP_648274.1	P-loop_NTPase	<357..435	CDD:304359	18/85 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2AMXB
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910