DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6834 and Y45G12C.4

DIOPT Version :9

Sequence 1:	NP_650104.2	Gene:	CG6834 / 41409	FlyBaseID:	FBgn0037935	Length:	895	Species:	Drosophila melanogaster
Sequence 2:	NP_503696.1	Gene:	Y45G12C.4 / 189933	WormBaseID:	WBGene00021567	Length:	431	Species:	Caenorhabditis elegans

Alignment Length:	496	Identity:	110/496 - (22%)
Similarity:	175/496 - (35%)	Gaps:	150/496 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 YIEKLLPWLDNKGFLEAYFINQVV--APETPSSEQPENPKNQILDWLNVSD---FAEVISSAEPE 514
            ::.|:..::...|.||.:...|.:  |.:.....:.:...|:.|  .|:||   |...|:..||:
Worm    10 FVRKMSLYVAADGILETHVTWQDIEEAMQASLGTKAKFGANKSL--RNISDLKGFQSKIALIEPD 72

  Fly   515 FDKIVGGSWSSATKPGDNFASKLLKIDIETQLKDHTSKTFSYILKVQPKSTPDNFTDVNMFPKEM 579
                    |..|.| ..|..|| ..:.|.|||   ....||.|.|         |...|.|.:|.
Worm    73 --------WVGAEK-NQNLPSK-FAVKISTQL---AFAVFSKITK---------FDGGNGFGEEK 115

  Fly   580 EMYQKYVPAFEQLYKDAGLTVTFTANSFVLNKAVKEEYLLMENLQTKGFKMADRMKGLNMEHTKS 644
            ..:                          |.|.::|.:    |.:.:.:|:.:::...::.|||:
Worm   116 LKF--------------------------LGKFIREGH----NREVEAYKLLEKLNHPDIPHTKA 150

  Fly   645 SLKKLAQWHAASIKYK-ELNG---------AYP-PLY---------------------NDGIYIE 677
                   ::....|.| :|.|         .:| |:|                     .:.:..|
Worm   151 -------YYLKPFKDKFDLKGFMILDFVPNVHPMPMYESIPADDLISLVRGVATFAGHGESLTAE 208

  Fly   678 QT-----RDVFHNMFAS--AKEAYIRIFGTFE---GAD-----EYLPKLEWIIDNHVDQVLEDAK 727
            |.     .|:|..||..  ..|...|:.|..:   ||.     |...||.||..|.:...   :|
Worm   209 QRSFARGSDIFELMFEEMYPDEQLERVCGVIQATFGAKNPAVVEECIKLFWIYKNSIKSY---SK 270

  Fly   728 INE-QAFN-VLNHGDAWINNIMFQYDAEGRLKETYLLDHQNAKYGNPAQDLYYFLISSAELDIKV 790
            ::| ..|. ||||||.|.:|::...|..|.|....::|.|......|..||...|:.......:.
Worm   271 VSELLGFKLVLNHGDLWQSNMLHCLDEHGNLVLKAIIDWQGVSMLPPGLDLARLLMGCLTAYERR 335

  Fly   791 DEFDNLIRFYHENLVEHTKLLKYNGFVP----SLSELH-AILIEHPAFAVGTVISTLT-VCLTDE 849
            :....|:..||:.         :.|.|.    ||.||. :..:.:|       |.||| |.:...
Worm   336 ERGAELLMLYHQT---------FTGIVGEELFSLEELQDSYNLYYP-------IMTLTLVPMVSS 384

  Fly   850 GF-NPELFFVETPESEAFRTKLLG------NERYKAHVEKI 883
            .| |.|:..||..::   |.|..|      .:..|.|.:.:
Worm   385 LFENSEMSEVEKTQA---RLKTEGKLFALLEDLVKVHEQNV 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6834	NP_650104.2	EcKinase	95..387	CDD:281023
CG6834	NP_650104.2	EcKinase	529..813	CDD:281023	70/332 (21%)
Y45G12C.4	NP_503696.1	DUF1679	16..422	CDD:369592	109/488 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2AMXB
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810