DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6830 and F59B1.8

DIOPT Version :9

Sequence 1:	NP_650103.1	Gene:	CG6830 / 41408	FlyBaseID:	FBgn0037934	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_504022.2	Gene:	F59B1.8 / 178784	WormBaseID:	WBGene00019100	Length:	420	Species:	Caenorhabditis elegans

Alignment Length:	475	Identity:	111/475 - (23%)
Similarity:	190/475 - (40%)	Gaps:	106/475 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 VSTDPLPPELLAALKPQQPQPENTDQIPDWLNIDDFKEII---------LSAEPNFEKI-----L 506
            :||.|     |:.|:|      .|......:.::|..:.|         |:||...|.|     .
Worm     1 MSTKP-----LSILQP------GTGLFNTHVTLEDVNKAIKEQMSTESELTAESKMEVIGEGNGF 54

  Fly   507 SSTSKLA----TKPGDNFASKLLK-----VEIEAQL-----KDNSVKTFSYILKVHSDNDAINFS 557
            ||...|.    |.|..:...||:.     |.::..|     :.|||.:......||:..:.....
Worm    55 SSCVILITCHWTIPSSHLPKKLILKIVSFVHVQGLLNKSNEEGNSVMSPEEEAHVHAHFEKSCQK 119

  Fly   558 DFNLFPKEIEVYSTYVPAFERFYKDVGLPVTFSPKSFRLSKDVSKEYLLLENLQPSGFKMVDRMI 622
            ..||   |:|    :..||... :.:.||..|..:.|. ..:.:|.::.:|.::.|..:.....:
Worm   120 GHNL---EVE----FCEAFGHL-EGLLLPKVFFSQKFE-EDNPNKGFVGMEFVEGSVVRHCYENV 175

  Fly   623 GMDLEHSKCTLKKLAQWHAASLKYKELNGPYSPKYNNG-IFTEQTAPI-----FKGMF---VNTK 678
            .:|  ..:..||.||:..|.||..:...     ..:|| .|.|....:     .||:|   .|..
Worm   176 TVD--ELQPILKALARLQALSLSTESCR-----NLDNGEAFEESLMDMLSEDGLKGIFDQSRNID 233

  Fly   679 KSFIEEVSKFDGVDEYLHKMPEILDTYVDRILEDAKINEQAFNVLNHGDAWINNIMFQYESDGRV 743
            :...|:|.:.    |..||  |||:  ::.:|...|:......|:.|||.|..||::. ::||..
Worm   234 QKLSEKVERI----EQNHK--EILN--LETVLNLNKVVGIDQKVICHGDLWAANILWT-QTDGGF 289

  Fly   744 KETLLLDHQVTKYGNPAQDLYYFIMSSTQLDIKVDQFDYLIRWYHQNMKEHAKLLNYNGFIPSLK 808
            ....:||:|.:..||||:||...::|:.....:...:::::..::....:.   :..|....:|:
Worm   290 IADKVLDYQESHMGNPAEDLVRLLVSTISGADRQSHWEHILEQFYTYFTDE---IGSNNAPYTLE 351

  Fly   809 ELH-AILIQHPIFAAGTVLTTLSMCLNKTTDDF--TTDSFLGNEENGKSLREAMFSNERY-RANI 869
            :|. :..:..|:.|    ||.:|:        |  ..|..|...|:||:        |.| |..|
Worm   352 QLKTSFKLYFPVGA----LTLISL--------FGPAVDMKLQGMESGKA--------ENYRRIVI 396

  Fly   870 ERVMPWINRRGLLDNFANGH 889
            |:|      ..|||:..|.|
Worm   397 EKV------DCLLDDVLNFH 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6830	NP_650103.1	EcKinase	80..372	CDD:281023
CG6830	NP_650103.1	EcKinase	516..800	CDD:281023	68/302 (23%)
F59B1.8	NP_504022.2	DUF1679	8..414	CDD:369592	107/463 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2AMXB
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810