DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6830 and AgaP_AGAP009056

DIOPT Version :9

Sequence 1:	NP_650103.1	Gene:	CG6830 / 41408	FlyBaseID:	FBgn0037934	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	XP_319807.4	Gene:	AgaP_AGAP009056 / 1280013	VectorBaseID:	AGAP009056	Length:	870	Species:	Anopheles gambiae

Alignment Length:	918	Identity:	222/918 - (24%)
Similarity:	407/918 - (44%)	Gaps:	136/918 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PEVDHSDLVPKWLNQTQFEELL-------AADVDQFSKIVGFRVKPAMAPGENYATLMLRISIDV 95
            |:......:|.:|:::..:.:|       ..:||.|:..:      |..||:||::.:.||.:..
Mosquito    11 PDAAAEKQLPAFLDESLLQYILDENLPDDPIEVDSFTAAI------ATKPGDNYSSDVYRIVVHY 69

  Fly    96 ELTDKSTKLVSFMMKVPHDTPQMEQMMSMANFFTSENAAYTEILPKMEELYKAKGLDIKFAPRAF 160
                ..:|::..:.|:..:.|.:::.......|..|......:||...::.......|||.  |.
Mosquito    70 ----NGSKVIPLVAKIMSEDPTVKEFGQRIGAFMKEVYTCRNLLPIFSQIVSRGSTRIKFG--AH 128

  Fly   161 KLDATKEPKVANTVLMHDLGQNGFKNINRLE-CLNLEQTKFALTRLAQFHAAGATMVQV-HGPYP 223
            .:.||::|  |:||:..||...|::..:|.. .|:|...:..:.::..|||  |:||.| .||
Mosquito   129 CVYATRDP--ADTVVFQDLNALGYRMPDRTRGGLDLAHCELIMRKIGLFHA--ASMVYVARGP-- 187

  Fly   224 DIFVNGVMGNNKEAIIAFMEGMLASFRTSF--------MAN---LDKFKNG-----------EEY 266
                              ||..|.:::.|.        ::|   |..|.||           .|.
Mosquito   188 ------------------MERQLFTYQYSHGMVQPRDNVSNNPGLKMFANGLDTFLEVSAGWPEL 234

  Fly   267 REKLEKALAGLTMEFMKLGIV-------DPNE--FNALNHGDCWMNNLLFKMNSSGD---LEDMV 319
            :.::...|..|.:.:.|....       |..|  |..|||||.|.||::|:...:.|   :.|::
Mosquito   235 KREIWTKLKALRLTYAKRCAQCLLTERHDQPEVTFRVLNHGDLWTNNMMFRYEDAADEGTVSDVL 299

  Fly   320 FVDFQNPKYGSPAMDLLYFIISSVQIDYKLSHFDFFIRHYQEALVKHLGILGFTGRKPSLRELHR 384
            |||:|...||||.:||:|.:.:..|.:.:.|..|..:|.|.|:|.:.|...|:....|:..::.:
Mosquito   300 FVDYQLGSYGSPGLDLVYCLHNCPQFEVRESSTDRLLRLYHESLCEGLSNGGYKQSFPTFEDVLK 364

  Fly   385 TLIKYGGWVLFPTISVLPLVLLDPTQSA--TFDNFMSDSADGVSFRGSLYANKRCQEYIERILPW 447
            ...::....|...:|:||::|::.|...  |..|.:. ....|..|...|..|   :|.:.:.|.
Mosquito   365 EYERHEFIGLVSGLSMLPIILMERTDEVELTMGNLVG-GEQAVKIRNIQYQGK---QYRQSLNPP 425

  Fly   448 LDNRGFLEVSTDPLPPELLAALKPQ--QPQPENTDQIPDWLNIDDFKEIIL--SAEPNFEK---I 505
            |.....|.....|..|...:|:...  .|:.:...|:|.:|.     |.::  |.|.:.::   |
Mosquito   426 LPTNRMLFGDRTPNAPHSTSAMSTTAGAPKQQQQHQLPSYLT-----ESLIQRSLEHDLQRPVTI 485

  Fly   506 LSSTSKLATKPGDNFASKLLKVEIEAQLKDNSVKTFSYILKVHSD--NDAINFSDFNLFPKEIEV 568
            ...|...||..|||:.|.:..:.:|   .|........:.|...|  :........:.|.||.|.
Mosquito   486 DRFTVGPATAAGDNYLSDVFWIRVE---YDGGASEKRLLAKCMPDIGDRGATLDVLDAFRKESET 547

  Fly   569 YSTYVPAFERFYKDVGLPVTFSPKSFRLSKDVSKEYLLLENLQPSGFKMVDRMI-GMDLEHSKCT 632
            :...:|.|.|.   ||....|..|.:..:.:..:. ::.|:|:..||:|.||.. |:|.:|....
Mosquito   548 FQHLLPEFTRL---VGGGEQFGAKCYYATTEPVRT-IVFEDLKALGFRMCDRTKGGLDYDHMTLV 608

  Fly   633 LKKLAQWHAASLKYKELNGPY----SPKYNNGIFTEQTAP--------IFKGMFVNTKKSFIEEV 685
            ::|:|::||||:.|.:.:..:    :.:|..|:...|..|        :.||:     :.||...
Mosquito   609 MRKIARFHAASMLYAKQSAEHQRRLASRYAYGLHNPQEQPEDSRILQALQKGL-----EKFISVA 668

  Fly   686 SKFDGVD-EYLHKMPEILDTYVDRILEDAKINEQA--FNVLNHGDAWINNIMFQYESDGR-VKET 746
            ..:..:| ..|.::..:|..:.:||....|..:..  :.||||||.|.||:||:|..|.: |:|.
Mosquito   669 GGWPELDGGVLRQLEALLPVFKERIAGCVKPRQPGARYEVLNHGDLWSNNMMFRYGPDDKTVEEI 733

  Fly   747 LLLDHQVTKYGNPAQDLYYFIMSSTQLDIKVDQFDYLIRWYHQNMKEHAKLLNYNGF--IPSLKE 809
            :.:|:|::.||:|..||.|.:.:....|:::.:...|::.||:.:   |..|..||:  :|::.:
Mosquito   734 IFVDYQISNYGSPGLDLVYTLYNCPHRDVRIARRAELLQEYHRVL---ADALRKNGYDRVPTMDD 795

  Fly   810 LHAILIQHPIFAAGTVLTTLS-MCLNKTTD-DFTTDSFLGNEENGKSLREAMFSNERYRANIERV 872
            :.....::..|.....:|.|. |.:.:|.| |.:.|:|. .|.:|:.||:..::...:|..:..:
Mosquito   796 VREEFTRNEFFGLVCAITFLPIMTMERTKDLDLSFDAFF-KEGHGEILRDRQYNGAVFRQAVVPI 859

  Fly   873 MPWINRRG 880
            :..::.||
Mosquito   860 LHDLHARG 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6830	NP_650103.1	EcKinase	80..372	CDD:281023	84/327 (26%)
CG6830	NP_650103.1	EcKinase	516..800	CDD:281023	79/302 (26%)
AgaP_AGAP009056	XP_319807.4	PKc_like	54..347	CDD:304357	83/322 (26%)
AgaP_AGAP009056	XP_319807.4	EcKinase	497..787	CDD:281023	80/304 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2AMXB
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D343262at33208
OrthoFinder	1	1.000	-	-		FOG0000277
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820