DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6830 and AgaP_AGAP013467

DIOPT Version :9

Sequence 1:	NP_650103.1	Gene:	CG6830 / 41408	FlyBaseID:	FBgn0037934	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	XP_003436594.1	Gene:	AgaP_AGAP013467 / 11175702	VectorBaseID:	AGAP013467	Length:	855	Species:	Anopheles gambiae

Alignment Length:	879	Identity:	265/879 - (30%)
Similarity:	450/879 - (51%)	Gaps:	81/879 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VPKWLNQTQFEELLA----ADVDQFSKIVGFRVKPAMAPGENYATLMLRISIDVEL-TDKSTKLV 105
            :|:|:..:.|.:.:|    ....:|| |....|:||...|:|:.::|.|:.:.|.| .::..|:|
Mosquito     9 IPEWMTSSFFIDAIAKAFNTAASEFS-IEHLDVRPATEAGDNFVSIMYRVKLTVLLNAEQDPKIV 72

  Fly   106 SFMMKVPHDTPQM---EQMMSMANFFTSENAAYTEILPKMEELYKAKGLDIKFAPRAFKLDATKE 167
            |.::|.   .||:   |:|::..|.|..|.|.||||||..|.||..:|:::.|.||..|  ...|
Mosquito    73 SLIVKA---LPQLGLSEEMITSMNVFPKEMAVYTEILPAFEALYSERGVNVAFGPRCLK--HCTE 132

  Fly   168 PKVANTVLMHDLGQNGFKNINRLECLNLEQTKFALTRLAQFHAAGATMVQVHGPYPDIFVNGVMG 232
            |  .:.::|.||....|:...|.:.|:||.....|.||||||||.|...:.:|||...|..|:..
Mosquito   133 P--TDIIVMEDLKDRDFQMAERQKGLDLEHCHTLLRRLAQFHAASAVYYERNGPYDAKFKEGMYA 195

  Fly   233 NNKEAIIAFMEGMLASFRTSFMANLDKF---------KNGEEYREKLEKALAGLTME----FMKL 284
            ....|:.           ..|.|..|:|         .||:.|.|.::    |..|:    .:::
Mosquito   196 EKNRAMF-----------EQFQAQHDRFMYDVMCKWPNNGKLYAELMK----GWGMDMFDAMLRI 245

  Fly   285 GIVDPNEFNALNHGDCWMNNLLFKMNSSGDLEDMVFVDFQNPKYGSPAMDLLYFIISSVQIDYKL 349
            ...||.:||.|||||.|.||::|:.:.|..::::..||||...:|||.:||.|||.|||:.:.||
Mosquito   246 TKPDPAKFNVLNHGDMWCNNMMFQYDDSSKIKEITLVDFQMCMWGSPVIDLHYFIFSSVRANLKL 310

  Fly   350 SHFDFFIRHYQEALVKHLGILGFTGRKPSLRELHRTLIKYGGWVLFPTISVLPLVLLDPTQSATF 414
            ...|..|.:|.|.|.::|.:|.:.|.:|||::||....:...:.|....||.|:.:::.|::|:.
Mosquito   311 RELDHLICYYYEQLTENLTLLQYGGARPSLQDLHSDFTERQLYGLSTAFSVFPICVMEKTENASI 375

  Fly   415 DNFMSDSADGVSFRGSLYANKRCQEYIERILPWLDNRGFLEVSTDPLPPELLAALKPQQPQPENT 479
            |..:.....|.:|:..:|......|.:..||.:..|.|..:::.       |.:.:|.:.:.::.
Mosquito   376 DLMLDQGDAGTAFKQKMYNGPAYVEQMAPILEYFYNSGAFDINQ-------LGSQRPAEIECDHA 433

  Fly   480 DQIPDWLNIDDFKEII---LSAEPNFEK--ILSSTSKLATKPGDNFASKLLKVEIEAQLKDNS-V 538
            ..:|.||:...|.:::   |...|..|:  |.:...:|||..|||:||.|.:.:::...:... |
Mosquito   434 LHLPLWLDRRFFDDVVAAKLGPCPTGERRHIRNVRVELATSKGDNYASMLYRAKVDVLTQGTGVV 498

  Fly   539 KTFSYILK-----VHSDNDA-INFSDFNLFPKEIEVYSTYVPAFERFYKDVGLPVTFSPKSFRLS 597
            ::||.|:|     |.:::.| :.||     .:||::|...:|||||.|.|.|..|.|||:..::.
Mosquito   499 ESFSTIVKAPPKGVLAEHTAYLAFS-----TREIQMYRELLPAFERLYHDKGETVRFSPRCLKVC 558

  Fly   598 KDVSKEYLLLENLQPSG-FKMVDRMIGMDLEHSKCTLKKLAQWHAASLKYKELNGPYSPKYNNGI 661
            :.:..:.::||:|..|| ::|.||..|:|..|::..|::||:.||:|..:.|.....|..::...
Mosquito   559 EAIPADVMVLEDLAHSGNYRMADRRAGLDQHHTELVLEQLAKLHASSAVFVEQGNALSGDFSGPK 623

  Fly   662 FTEQTAPIFKGMFVNTKKSFIEEVSKFDGV--DEYLHKMPEILDTYVDRILEDAKINEQAFNVLN 724
            .||....:.|.:|.....|.:|.::.::.:  |.|........|.: :::.......|..|||||
Mosquito   624 VTESLKTMGKELFQPMLDSLVEFMASWNFLTPDHYTDLKAAAKDAF-EQLATIITPREDRFNVLN 687

  Fly   725 HGDAWINNIMFQYESDGRVKET----LLLDHQVTKYGNPAQDLYYFIMSSTQLDIKVDQFDYLIR 785
            |||.|:||:||.|.|......|    .|||.|:..:.:|..||:.|:.||.:.|:|:...:|.:|
Mosquito   688 HGDLWVNNVMFSYASGATGAPTATGVTLLDFQMCCWASPMVDLHSFLFSSVRADLKLTHLNYFLR 752

  Fly   786 WYHQNMKEHAKLLNYNGFIPSLKELHAILIQHPIFAAGTV--LTTLSMCLNKTTDDFTTDSFL-G 847
            :|.:.:.:...||.|...||:|::|  ::..:.:...|.|  |..|...|....||.:.|:.: |
Mosquito   753 YYQEKLADSLVLLGYRKRIPTLQQL--LVDFNDLLMCGLVSALLALPFALVPNVDDASLDAVVEG 815

  Fly   848 NEENGKSLREAMFSNERYRANIERVMPWINRRGL 881
            :.|.|:..::.||.||..:..::.::|:...||:
Mosquito   816 STEAGQRFQKQMFDNEELKTQLKVLLPYFRNRGV 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6830	NP_650103.1	EcKinase	80..372	CDD:281023	106/308 (34%)
CG6830	NP_650103.1	EcKinase	516..800	CDD:281023	92/297 (31%)
AgaP_AGAP013467	XP_003436594.1	EcKinase	47..333	CDD:281023	106/307 (35%)
AgaP_AGAP013467	XP_003436594.1	EcKinase	475..767	CDD:281023	92/297 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	207	1.000	Domainoid score	I6156
eggNOG	1	0.900	-	-		E1_2AMXB
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H138253
Inparanoid	1	1.050	403	1.000	Inparanoid score	I3931
OMA	1	1.010	-	-		QHG27462
OrthoDB	1	1.010	-	-		D101022at50557
OrthoFinder	1	1.000	-	-		FOG0000277
OrthoInspector	1	1.000	-	-		mtm9677
Panther	1	1.100	-	-	O	PTHR11012
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11768
TreeFam	1	0.960	-	-
	13	12.940