DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ho and hmox1a

DIOPT Version :9

Sequence 1:	NP_524321.1	Gene:	Ho / 41407	FlyBaseID:	FBgn0037933	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_001120988.1	Gene:	hmox1a / 791518	ZFINID:	ZDB-GENE-030131-3102	Length:	272	Species:	Danio rerio

Alignment Length:	225	Identity:	56/225 - (24%)
Similarity:	96/225 - (42%)	Gaps:	42/225 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DSQVSENVEDVEFVDMAFTKELRKATKDVHNLTDVLVNAKIALALSDDEV---WYDGLL-AFYEL 70
            ||..|:..|:   .....:::::..|||.|...:   |.::.|:....::   .|..|| :.||:
Zfish     2 DSTKSKAAEN---TGSDLSEQIKAVTKDSHVRAE---NTQLMLSYQKGQITQTQYKLLLCSLYEI 60

  Fly    71 YKFFETHLPER---------LLPKEFHRTAAFERDFAYFYGSDWRKDYEIRPAVQKYLEHLEKIA 126
            |:..|..|...         ..|:|..|..|..:|..:|:|..|||...:..|..:|.:.|.:|.
Zfish    61 YRALEEELDRNADHPAVQPIYFPQELARLEALGQDLEHFFGPQWRKRITVPAATHRYAQRLREIG 125

  Fly   127 AQNELLLFAYSYQMYMALMSGGQMLQK-----KRMIARKMWIF-----------------SKNDD 169
            ..:..||.|::|..|:..:||||:|.|     ..:...|..:|                 |:.:.
Zfish   126 KSSPELLVAHAYTRYLGDLSGGQVLGKITQKSLGLTGNKGILFFSFPGVTSANRFKQLYRSRMNS 190

  Fly   170 EEQQKQADKEAELATARAADGSVDK-DDLE 198
            .|..:|..:||.....||.:.::|. |||:
Zfish   191 IEFTEQKRQEALDEAVRAFEFNIDVFDDLQ 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ho	NP_524321.1	Heme_oxygenase	25..265	CDD:279470	52/210 (25%)
hmox1a	NP_001120988.1	Heme_oxygenase	14..218	CDD:279470	49/206 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596039
Domainoid	1	1.000	72	1.000	Domainoid score	I9281
eggNOG	1	0.900	-	-		E1_COG5398
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1424194at2759
OrthoFinder	1	1.000	-	-		FOG0002659
OrthoInspector	1	1.000	-	-		otm24336
orthoMCL	1	0.900	-	-		OOG6_104451
Panther	1	1.100	-	-	LDO	PTHR10720
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2150
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.740