Protein Alignment Ho and HMOX1

DIOPT Version :9

• Sequence 1: NP_524321.1
• Gene: Ho / 41407
• FlyBaseID: FBgn0037933
• Length: 296
• Species: Drosophila melanogaster
• Sequence 2: NP_002124.1
• Gene: HMOX1 / 3162
• HGNCID: 5013
• Length: 288
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 62/256 - (24%)
• Similarity: 109/256 - (42%)
• Gaps: 67/256 - (26%)

  Fly    28 TKELRKATKDVHNLTDVLVNAKIALALSDDEVWYDG----LLAFYELYKFFETHLPER------- 81
            ::.|::|||:||...:   ||:........:|..||    :.:.|.:|...|..: ||
Human    14 SEALKEATKEVHTQAE---NAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEI-ERNKESPVF 74

  Fly    82 ---LLPKEFHRTAAFERDFAYFYGSDWRKDYEIRPAVQKYLEHLEKIAAQNELLLFAYSYQMYMA 143
               ..|:|.||.||.|:|.|::||..|::.....||:|:|::.|.::......||.|::|..|:.
Human    75 APVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLG 139

  Fly   144 LMSGGQMLQKKRMIARKMWIFSKNDDEEQQKQADKEAELATARAADGSVDKDDLEARPMPAQVTI 208
            .:||||:|:|   ||:|                                      |..:|:.
Human   140 DLSGGQVLKK---IAQK--------------------------------------ALDLPSS--- 160

  Fly   209 CPPGCEATYFPEKISVLKAKLRRVFNNHYGAFD--DDLRAAFIEESRNVFRLNIEVVRTIK 267
             ..|.....||...|.  .|.::::.:...:.:  ..:|...|||::..|.|||::...::
Human   161 -GEGLAFFTFPNIASA--TKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQ 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ho	NP_524321.1	Heme_oxygenase	25..265	CDD:279470	62/252 (25%)
HMOX1	NP_002124.1	Heme_oxygenase	11..216	CDD:395895	62/252 (25%)
		kinked helix	127..154	CDD:350855	14/67 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	223..260

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159802
Domainoid	1	1.000	74	1.000	Domainoid score	I9158
eggNOG	1	0.900	-	-		E1_COG5398
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	68	1.000	Inparanoid score	I5340
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1424194at2759
OrthoFinder	1	1.000	-	-		FOG0002659
OrthoInspector	1	1.000	-	-		otm41705
orthoMCL	1	0.900	-	-		OOG6_104451
Panther	1	1.100	-	-	LDO	PTHR10720
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2150
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.790