DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and ZNF254

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_975011.3	Gene:	ZNF254 / 9534	HGNCID:	13047	Length:	659	Species:	Homo sapiens

Alignment Length:	744	Identity:	164/744 - (22%)
Similarity:	262/744 - (35%)	Gaps:	231/744 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 YNRI-QKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEALEAHL 253
            ||.: |.:.|.:..|::|....:.|  :.||..:..::...|.:.:.|...::.|........|.
Human   139 YNGLNQCFTTAQSKVFQCDKYLKVF--YKFLNSNRPKIRHTEKKSFKCKKRVKLFCMLSHKTQHK 201

  Fly   254 KIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRRH----LEEHPDIVS 314
            .|:...|                      .||   |..|...:|..:.|..|    .||.|   .
Human   202 SIYHREK----------------------SYK---CKECGKTFNWSSTLTNHRKIYTEEKP---Y 238

  Fly   315 LCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDSD 379
            .|...|..|.:|:.|
Human   239 KCEEYNKSPKQLSTL-------------------------------------------------- 253

  Fly   380 LDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLL 444
              ..|:..|...|     .|.||.|.:.|.|...|..| :..|: .:.|:.|..|...|:....|
Human   254 --TTHEIIHAGEK-----LYKCEECGEAFNRSSNLTTH-KIIHT-GEKPYKCEECGKAFIWSSTL 309

  Fly   445 RHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLS 509
            ..|.:...|  :|.:.|.:|...|.|...|..|.|.| ...:.::|.||.:.|.:..:||.|.:
Human   310 TEHKKIHTR--KKPYKCEECGKAFIWSSTLTRHKRMH-TGEKPYKCEECGKAFSQSSTLTTHKI- 370

  Fly   510 VHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLH 574
            :|                                                 .|.||..|..|...
Human   371 IH-------------------------------------------------TGEKRYKCLECGKA 386

  Fly   575 FERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICE 639
            |:::..|..|     |:   :|                                 ||.: :|.||
Human   387 FKQLSTLTTH-----KI---IH---------------------------------VGEK-LYKCE 409

  Fly   640 LCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYK 704
            .|.....|...:..| :.:|..:| |::|::|....:..|.:..|:  :..:.||.:.|.:|...
Human   410 ECGKGFNRSSNLTTH-KIIHTGEK-PYKCEECGKAFIWSSTLTKHK--RIHTREKPYKCEECGKA 470

  Fly   705 FMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNH 769
            |:|...|.:|..:.         ||::.                  .:|..|.:::...|.|..|
Human   471 FIWSSTLTRHKRMH---------TGEKP------------------YKCEECGKSFSQSSTLTTH 508

  Fly   770 IRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASH 834
             :.:| .|:       |.:.|..||.....::.|..|...||.|||:||:.|..||.:.|.|.:|
Human   509 -KIIH-TGE-------KPYKCEECGKAFNWSSTLTKHKIIHTEEKPYKCEKCGKAFKQSSILTNH 564

  Fly   835 RRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECP 899
            :|:||||||:.|..|||.|.||....:|.:.|:|:||:||..|.|::..:..|..|.:.||||.|
Human   565 KRIHTGEKPYKCEECGKSFNRSSTFTKHKVIHTGVKPYKCEECGKAFFWSSTLTKHKRIHTGEQP 629

  Fly   900 FVCGTCGERFIQSSTLEKHRLMRRHFDEV 928
            :.....|:.|.:||.|...::  .|:.|:
Human   630 YKWEKFGKAFNRSSHLTTDKI--THWREI 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368	4/20 (20%)
		C2H2 Zn finger	236..256	CDD:275368	3/19 (16%)
		C2H2 Zn finger	401..422	CDD:275368	7/20 (35%)
		C2H2 Zn finger	431..447	CDD:275368	4/15 (27%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	0/19 (0%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	4/21 (19%)
		C2H2 Zn finger	698..715	CDD:275368	5/16 (31%)
		C2H2 Zn finger	753..774	CDD:275368	5/20 (25%)
		C2H2 Zn finger	790..810	CDD:275368	5/19 (26%)
		zf-H2C2_2	802..825	CDD:290200	10/22 (45%)
		COG5048	814..>886	CDD:227381	33/71 (46%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	14/24 (58%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	5/19 (26%)
		C2H2 Zn finger	902..924	CDD:275368	5/21 (24%)
ZNF254	NP_975011.3	KRAB	13..73	CDD:214630
		C2H2 Zn finger	184..204	CDD:275368	3/19 (16%)
		C2H2 Zn finger	212..260	CDD:275368	14/102 (14%)
		COG5048	264..625	CDD:227381	120/502 (24%)
		C2H2 Zn finger	268..288	CDD:275368	7/20 (35%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		C2H2 Zn finger	352..372	CDD:275368	7/20 (35%)
		C2H2 Zn finger	380..400	CDD:275368	6/27 (22%)
		C2H2 Zn finger	408..428	CDD:275368	5/20 (25%)
		C2H2 Zn finger	436..456	CDD:275368	4/21 (19%)
		C2H2 Zn finger	464..484	CDD:275368	6/19 (32%)
		C2H2 Zn finger	492..512	CDD:275368	5/20 (25%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	548..568	CDD:275368	8/19 (42%)
		C2H2 Zn finger	576..596	CDD:275368	8/19 (42%)
		C2H2 Zn finger	604..624	CDD:275368	5/19 (26%)
		C2H2 Zn finger	632..652	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910