DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and ZNF585B

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_689492.3	Gene:	ZNF585B / 92285	HGNCID:	30948	Length:	769	Species:	Homo sapiens

Alignment Length:	846	Identity:	212/846 - (25%)
Similarity:	330/846 - (39%)	Gaps:	208/846 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 ELPEPDETDMESKKSVDPLTMIETVKLEMEPRSV--EKPAYDDPTSDFEDEDS----LDNLPLYN 191
            ::|:|:...:|..|               ||.::  |:|.:..|.....|.:.    :...|..:
Human    69 QVPKPEVVMLEQGK---------------EPWALQGERPRHSCPGEKLWDHNQHRKIIGYKPASS 118

  Fly   192 RIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEALEAHLKIH 256
            :.||..:|.|| |:|.:..:||......|.| ::|...| :||.|..|.|.|.:......|.|.|
Human   119 QDQKIYSGEKS-YECAEFGKSFTWKSQFKVH-LKVPTGE-KLYVCIECGRAFVQKPEFITHQKTH 180

  Fly   257 RNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPD----IVSLCG 317
            ...                    ||:     :|..|...:.:::.|.||...|..    ..|.||
Human   181 MRE--------------------KPY-----KCNECGKSFFQVSSLFRHHRIHTGEKLYECSECG 220

  Fly   318 RPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDSDLDG 382
            :.           :|.:.|||       |.:.:..|  :|.:..|       |...:.|......
Human   221 KG-----------FPYNSDLS-------IHEKIHTG--ERHHECT-------DCGKAFTQKSTLK 258

  Fly   383 DHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHH 447
            .|...|     :.:.:|.|..|.|.|.:|.||..| |:.|| .:.|:.|..|...|:|...|:.|
Human   259 IHQKIH-----TGERSYICIECGQAFIQKTQLIAH-RRIHS-GEKPYECNNCGKSFISKSQLQVH 316

  Fly   448 NESQCR--------------------------NAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQ 486
            .....|                          :.:|..:|.:|...|.::..|..|.|.| ...:
Human   317 QRVHTRVKPYICTEYGKVFSNNSNLITHEKIQSREKSSICTECGKAFTYRSELIIHQRIH-TGEK 380

  Fly   487 TFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAE 551
            .:|||:|.|.|.:|.:|||| ..:|..|...| |..|...|.|..:|:.|...|
Human   381 PYECSDCGRAFTQKSALTVH-QRIHTGEKSYI-CMKCGLAFIRKAHLITHQIIH----------- 432

  Fly   552 TLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPH-----NYSITNES 611
                     .|.|...|..|...|.....|..|.::         .:.:.|:     ..:.||.|
Human   433 ---------TGEKPYKCGHCGKLFTSKSQLHVHKRI---------HTGEKPYVCNKCGKAFTNRS 479

  Fly   612 GFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCV 676
            ..       .|..:...|..|   |||..|.....::.::|.||| :|..:| |:||:.|.....
Human   480 NL-------ITHQKTHTGEKS---YICSKCGKAFTQRSDLITHQR-IHTGEK-PYECNTCGKAFT 532

  Fly   677 SKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEK 741
            .||.::.|:  :..:.|:::.|.:|...|.     ::.||:.|.|..            ||:...
Human   533 QKSNLNIHQ--KIHTGERQYECHECGKAFN-----QKSILIVHQKIH------------TGEKPY 578

  Fly   742 DATEDGIPLL------------------QCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRF 788
            ..||.|...:                  :|..|.:::..||:|..| :.|| .|:       |.:
Human   579 VCTECGRAFIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVH-QPVH-TGE-------KPY 634

  Fly   789 LCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDF 853
            :|:.||......:.|..|.:.||||||:.|..|...|.:.|||.:|.|:||||||:.|:.|||.|
Human   635 VCAECGKAFSGRSNLSKHQKTHTGEKPYICSECGKTFRQKSELITHHRIHTGEKPYECSDCGKSF 699

  Fly   854 ARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKH 918
            .:..:|:.|...|:|.||:.|..|.|::....:|..|...|||:.|:.||.||:.|:|.|....|
Human   700 TKKSQLQVHQRIHTGEKPYVCAECGKAFSNRSNLNKHQTTHTGDKPYKCGICGKGFVQKSVFSVH 764

  Fly   919 R 919
            :
Human   765 Q 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368	5/20 (25%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		C2H2 Zn finger	401..422	CDD:275368	9/20 (45%)
		C2H2 Zn finger	431..447	CDD:275368	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..511	CDD:275368	10/20 (50%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	6/20 (30%)
		C2H2 Zn finger	668..690	CDD:275368	5/21 (24%)
		C2H2 Zn finger	698..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	5/19 (26%)
		zf-H2C2_2	802..825	CDD:290200	10/22 (45%)
		COG5048	814..>886	CDD:227381	30/71 (42%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	15/24 (63%)
		C2H2 Zn finger	846..866	CDD:275368	7/19 (37%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	5/19 (26%)
		C2H2 Zn finger	902..924	CDD:275368	8/18 (44%)
ZNF585B	NP_689492.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		KRAB	27..85	CDD:214630	5/30 (17%)
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	132..152	CDD:275368	5/20 (25%)
		COG5048	156..529	CDD:227381	109/475 (23%)
		C2H2 Zn finger	160..180	CDD:275368	6/19 (32%)
		C2H2 Zn finger	188..208	CDD:275368	5/19 (26%)
		C2H2 Zn finger	216..236	CDD:275368	8/37 (22%)
		zf-H2C2_2	228..253	CDD:290200	8/40 (20%)
		C2H2 Zn finger	244..264	CDD:275368	4/26 (15%)
		C2H2 Zn finger	272..292	CDD:275368	9/20 (45%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		C2H2 Zn finger	328..347	CDD:275368	0/18 (0%)
		COG5048	335..768	CDD:227381	136/503 (27%)
		C2H2 Zn finger	356..376	CDD:275368	6/19 (32%)
		zf-H2C2_2	368..393	CDD:290200	10/25 (40%)
		C2H2 Zn finger	384..404	CDD:275368	10/20 (50%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		zf-H2C2_2	424..449	CDD:290200	8/44 (18%)
		C2H2 Zn finger	440..460	CDD:275368	5/28 (18%)
		zf-H2C2_2	455..477	CDD:290200	2/30 (7%)
		C2H2 Zn finger	468..488	CDD:275368	4/26 (15%)
		C2H2 Zn finger	496..516	CDD:275368	6/20 (30%)
		zf-H2C2_2	508..533	CDD:290200	10/26 (38%)
		C2H2 Zn finger	524..544	CDD:275368	5/21 (24%)
		zf-H2C2_2	536..561	CDD:290200	5/31 (16%)
		C2H2 Zn finger	552..572	CDD:275368	7/24 (29%)
		zf-H2C2_2	565..589	CDD:290200	8/35 (23%)
		C2H2 Zn finger	580..600	CDD:275368	3/19 (16%)
		zf-H2C2_2	592..617	CDD:290200	2/24 (8%)
		C2H2 Zn finger	608..628	CDD:275368	6/20 (30%)
		C2H2 Zn finger	636..656	CDD:275368	5/19 (26%)
		zf-H2C2_2	648..673	CDD:290200	11/24 (46%)
		C2H2 Zn finger	664..684	CDD:275368	8/19 (42%)
		zf-H2C2_2	676..700	CDD:290200	14/23 (61%)
		C2H2 Zn finger	692..712	CDD:275368	7/19 (37%)
		zf-H2C2_2	705..729	CDD:290200	9/23 (39%)
		C2H2 Zn finger	720..740	CDD:275368	5/19 (26%)
		zf-H2C2_2	732..757	CDD:290200	11/24 (46%)
		C2H2 Zn finger	748..768	CDD:275368	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100