DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and ZNF394

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_115540.2	Gene:	ZNF394 / 84124	HGNCID:	18832	Length:	561	Species:	Homo sapiens

Alignment Length:	397	Identity:	110/397 - (27%)
Similarity:	163/397 - (41%)	Gaps:	104/397 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   547 IPLAETLIAATSRPNG-------AKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSP-- 602
            ||:.:.|..|  .|.|       .||.....|....|..|:.::...|.|||.       :||
Human   206 IPMQQILEEA--EPQGQLQEAFQGKRPLFSKCGSTHEDRVEKQSGDPLPLKLE-------NSPEA 261

  Fly   603 ---HNYSITNESGFELQLEDSETEDEMQPGVGSRPVYIC------------ELCSVQCKRKFEMI 652
               ::.|..|::| .::.|||: .:|:|.......:.:|            |....:||:.|.|:
Human   262 EGLNSISDVNKNG-SIEGEDSK-NNELQNSARCSNLVLCQHIPKAERPTDSEEHGNKCKQSFHMV 324

  Fly   653 ----------------------QHQRTMHRFDKMPHECDDCIFKCVSKSI---MDHHRQGQCSST 692
                                  :.||.:|  ::.|::|.:|     .||.   .|..|..:..:.
Human   325 TWHVLKPHKSDSGDSFHHSSLFETQRQLH--EERPYKCGNC-----GKSFKQRSDLFRHQRIHTG 382

  Fly   693 EKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCD 757
            ||.:.|.:|...|.....|.:|                   |.|...||..|        |..|.
Human   383 EKPYGCQECGKSFSQSAALTKH-------------------QRTHTGEKPYT--------CLKCG 420

  Fly   758 RTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCE 822
            ..::..|.||.| :..|...        |.|.|..|| ||...:.|..|.|.|.||:|:||:.||
Human   421 ERFRQNSHLNRH-QSTHSRD--------KHFKCEECG-ETCHISNLFRHQRLHKGERPYKCEECE 475

  Fly   823 MAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDL 887
            .:|.:.|:|..|.|:||||||:.|:||||.|.:|..|.:|...|:|.||:||..|.:.:||:..|
Human   476 KSFKQRSDLFKHHRIHTGEKPYGCSVCGKRFNQSATLIKHQRIHTGEKPYKCLECGERFRQSTHL 540

  Fly   888 KLHLQQH 894
            ..|.:.|
Human   541 IRHQRIH 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	401..422	CDD:275368
		C2H2 Zn finger	431..447	CDD:275368
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	490..511	CDD:275368
		C2H2 Zn finger	520..540	CDD:275368
		C2H2 Zn finger	638..659	CDD:275368	8/54 (15%)
		C2H2 Zn finger	668..690	CDD:275368	6/24 (25%)
		C2H2 Zn finger	698..715	CDD:275368	4/16 (25%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	8/19 (42%)
		zf-H2C2_2	802..825	CDD:290200	11/22 (50%)
		COG5048	814..>886	CDD:227381	34/71 (48%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	15/24 (63%)
		C2H2 Zn finger	846..866	CDD:275368	9/19 (47%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	6/19 (32%)
		C2H2 Zn finger	902..924	CDD:275368
ZNF394	NP_115540.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		SCAN	60..170	CDD:128708
		KRAB_A-box	155..214	CDD:322003	3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..285		15/62 (24%)
		C2H2 Zn finger	337..353	CDD:275368	2/15 (13%)
		COG5048	356..>420	CDD:227381	20/95 (21%)
		C2H2 Zn finger	360..380	CDD:275368	6/24 (25%)
		C2H2 Zn finger	388..408	CDD:275368	6/38 (16%)
		zf-C2H2	414..436	CDD:306579	7/30 (23%)
		C2H2 Zn finger	416..436	CDD:275368	6/20 (30%)
		C2H2 Zn finger	444..463	CDD:275368	8/19 (42%)
		SFP1	<464..543	CDD:227516	37/78 (47%)
		C2H2 Zn finger	471..491	CDD:275368	8/19 (42%)
		C2H2 Zn finger	499..519	CDD:275368	9/19 (47%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910