DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and ZNF408

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_079017.1	Gene:	ZNF408 / 79797	HGNCID:	20041	Length:	720	Species:	Homo sapiens

Alignment Length:	401	Identity:	99/401 - (24%)
Similarity:	157/401 - (39%)	Gaps:	93/401 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   601 SPHNYSITN--ESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFD- 662
            ||......|  ..|.:...:|..::|....|...:...:.|.|..|.:...|:..:..|....|
Human   223 SPSGIQAENMVSPGLKFPTQDRISKDSQPLGPLLQDGDVDEECPAQAQMPPELQSNSATQQDPDG 287

  Fly   663 -----------KMPH---------ECDDCI--------------FKCVSKSIMDHHRQGQCSSTE 693
                       ..||         ..|.|.              |..:|:|     ..|...|:.
Human   288 SGASFSSSARGTQPHGYLAKKLHSPSDQCPPRAKTPEPGAQQSGFPTLSRS-----PPGPAGSSP 347

  Fly   694 K---KHACGKCSYKFMWPENLEQH----------ILLQHSKSSVSNPTGDRHTQGTGDLEKDATE 745
            |   ::.||:|...|:...:|::|          :..:..||..|..:...|..|         .
Human   348 KQGRRYRCGECGKAFLQLCHLKKHAFVHTGHKPFLCTECGKSYSSEESFKAHMLG---------H 403

  Fly   746 DGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDR-----------KRKEAIKRFL---------- 789
            .|:....||.||:.|..:..|..| :.|| :|.|           .|:.:::...
Human   404 RGVRPFPCPQCDKAYGTQRDLKEH-QVVH-SGARPFACDQCGKAFARRPSLRLHRKTHQVPAAPA 466

  Fly   790 ---CSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGK 851
               |.:||....:..:|..|||.|||||||.|..|..||.:...|..|.|:||||:|:.|..|..
Human   467 PCPCPVCGRPLANQGSLRNHMRLHTGEKPFLCPHCGRAFRQRGNLRGHLRLHTGERPYRCPHCAD 531

  Fly   852 DFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLE 916
            .|.:..:|:||:::|:| :.|.|..|.|:.|....|:.|.:.|:||.||.|..||..:..::.|.
Human   532 AFPQLPELRRHLISHTG-EAHLCPVCGKALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLR 595

  Fly   917 KHRLMRRHFDE 927
            :|  ::.|.::
Human   596 RH--LKSHLED 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	401..422	CDD:275368
		C2H2 Zn finger	431..447	CDD:275368
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	490..511	CDD:275368
		C2H2 Zn finger	520..540	CDD:275368
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	6/35 (17%)
		C2H2 Zn finger	698..715	CDD:275368	6/26 (23%)
		C2H2 Zn finger	753..774	CDD:275368	7/20 (35%)
		C2H2 Zn finger	790..810	CDD:275368	7/19 (37%)
		zf-H2C2_2	802..825	CDD:290200	13/22 (59%)
		COG5048	814..>886	CDD:227381	28/71 (39%)
		C2H2 Zn finger	818..838	CDD:275368	7/19 (37%)
		zf-H2C2_2	830..855	CDD:290200	11/24 (46%)
		C2H2 Zn finger	846..866	CDD:275368	6/19 (32%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	6/19 (32%)
		C2H2 Zn finger	902..924	CDD:275368	5/21 (24%)
ZNF408	NP_079017.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..350		23/131 (18%)
		COG5048	<308..516	CDD:227381	52/223 (23%)
		C2H2 Zn finger	355..375	CDD:275368	6/19 (32%)
		zf-H2C2_2	367..392	CDD:290200	4/24 (17%)
		C2H2 Zn finger	383..403	CDD:275368	5/28 (18%)
		C2H2 Zn finger	411..431	CDD:275368	7/20 (35%)
		zf-H2C2_2	423..448	CDD:290200	6/26 (23%)
		C2H2 Zn finger	439..490	CDD:275368	8/50 (16%)
		COG5048	<475..642	CDD:227381	49/133 (37%)
		zf-H2C2_2	482..507	CDD:290200	15/24 (63%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..533	CDD:290200	10/22 (45%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		C2H2 Zn finger	553..573	CDD:275368	6/19 (32%)
		zf-H2C2_2	566..589	CDD:290200	10/22 (45%)
		C2H2 Zn finger	581..601	CDD:275368	5/21 (24%)
		zf-H2C2_2	594..617	CDD:290200	3/13 (23%)
		C2H2 Zn finger	609..629	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000