DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Zfp142

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001297597.1	Gene:	Zfp142 / 77264	MGIID:	1924514	Length:	1843	Species:	Mus musculus

Alignment Length:	1187	Identity:	250/1187 - (21%)
Similarity:	381/1187 - (32%)	Gaps:	409/1187 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TPSKKYP-----------DKLLSEILCELTEINLDATGSQKFPQCLCSGCT----------KKLM 66
            ||:..||           ..|||...|:.|.:       ::|...||...|          :|:.
Mouse   739 TPAPLYPCRYCSYQSRHKQALLSHENCKHTHL-------REFHCALCDYRTFSNTTLFFHKRKVH 796

  Fly    67 G--------AYCYVKQAM-AANELLMKHLKNG--------------------------------- 89
            |        .:|...|.: .|.:.|.....:|
Mouse   797 GYMPGDQVWQFCNASQELEGARQCLAPPSDSGPSSQLSAQPEREDREHEIVANSNMDQALPETNE 861

  Fly    90 -AAPTSTDCLQEAPMELCAEQ----------------HVE---VKLETEDEDCGENDVTITCS-- 132
             |:|...|.: |||.|  .:|                |:|   |:||.|.|.....::|.|.:
Mouse   862 EASPKRQDGI-EAPQE--DDQVDSPSLGEVEEGGCTLHLEALRVELEPETEPLPLEELTETATVE 923

  Fly   133 -----------------------------ELP------EPDETDMESKKSVDPLTMIE---TVKL 159
                                         |.|      ||....:.|:...:||...|   |.|.
Mouse   924 FRPLDPSGPLGTERPGGLEEPALSSFDSIETPALVAEEEPVVEKLASEPPRNPLISEEAPNTFKA 988

  Fly   160 EMEPRSVEKPAYDDPTSDF-----EDEDSLDNLPLYNRIQKWK-TGRKSVYKCHDCPRSFKRFDF 218
            .:...:|..|.:.:..|..     :|::..:.|.|..|:|... .|....::|..||       |
Mouse   989 ALTAETVPLPPFPESESLLKAMRRQDKEQAEALVLEGRVQMVVIQGEGRAFRCPHCP-------F 1046

  Fly   219 LKRHE--MRVH-------KPETRLYDCSLCIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAV 274
            :.|.|  :.:|       :.|..|  |..|...|.:...|..|:     .|:...:.:..||
Mouse  1047 ITRREKALTLHSKSGCQGRREPLL--CPECGASFKQQRGLSTHM-----MKKCPVLLKKNKA--- 1101

  Fly   275 DLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVS-------------LCGRPNMEPHEL 326
               |.||.. ..:...:..:|.::.|:.|:    .|.:.|             |.|.|.:|....
Mouse  1102 ---LPKPVS-PTLHPQLPDNQASQDAESRK----PPPLPSKVELLLPKDAPSDLPGGPGVEEPLP 1158

  Fly   327 AELFYPDSKDLSEEQLINLIRKDLAAGIYQRFY-------------------SITN--------- 363
            ....:|.|..          ...|..|..::|:                   |||:
Mouse  1159 TPSDFPTSPP----------ENSLPTGTSEKFHFEQGKFHCSSCTFLCSRLSSITSHVTEGCRGG 1213

  Fly   364 -------------------QSGYEMDLDSSETDSD-LDGDHDDQHKRRKKSRKATYSCELCQQKF 408
                               .:|....|::..|:|. .|||    ....:|.:.|.:||..|....
Mouse  1214 RGQKRKRGRPQTHAVVLPLNNGDSTLLNTGSTESSPSDGD----TAVVQKQKGALFSCPTCPFSC 1274

  Fly   409 PRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHH-------------------------- 447
            .::..|..||.|..........||.|.....:...||.|
Mouse  1275 QQERTLRTHQTQGCPLKSGDLHCGLCPFTAPAAAALRLHQKRRHPTASPASGPRPLLQCGDCGFT 1339

  Fly   448 -NESQCRNAQKRF-----LCHKCPL-------RFRWKHNLKTHFREHRITNQTFECSECKRVFDK 499
             .:|:|....:|.     ..|:||.       |:|.:.:...|....||     .||.|.:.|..
Mouse  1340 CKQSRCLQQHRRLKHEGVKPHQCPFCDFSTTRRYRLEAHQSRHTGVGRI-----PCSSCPQTFGT 1399

  Fly   500 KKSLTVHLLSVHAEESKLIPCQWCSRKFY-RHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGA 563
            ...|.:|.|.|| :::....|..|....| |||     :.||               ..|...|.
Mouse  1400 NSKLRLHQLRVH-DKTPTHFCPLCDYSGYLRHD-----ITRH---------------VNSCHQGT 1443

  Fly   564 KRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQP 628
            ...:|..|...|.....|:.|       :|..|.....|       .||..:::.:.
Mouse  1444 PSFSCTQCEAQFSSETALKQH-------ALRRHPEPTPP-------SSGCPVEVTEG-------- 1486

  Fly   629 GVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPH-ECDDCIFKCVSKSIMDHHRQGQCSST 692
                 |:: |..|.:.|.....:..|.|..|     |. ||..|.....::..:|.||:....|
Mouse  1487 -----PLH-CSHCGLLCPSPASLRGHTRKQH-----PRLECGACQESFPNRPALDEHRRQHHFS- 1539

  Fly   693 EKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCD 757
               |.|..||:.......|.:|.|.||.:||.:...||.               |.|.|.||.||
Mouse  1540 ---HRCQLCSFAARERVGLVKHYLEQHEESSTAPSDGDA---------------GQPSLCCPFCD 1586

  Fly   758 RTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCE 822
            ...:.:..|::|::. | .|.|..|       |:.|...|::...:..|.|.||||||:.|.||.
Mouse  1587 FACRHQLVLDHHVKG-H-GGTRLYK-------CTDCAYSTKNRQKITWHSRIHTGEKPYHCHLCA 1642

  Fly   823 MAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCE--------- 878
            .|....|.|..|.|:|..|:.:.|..||......::||.||..|:||||::|..||
Mouse  1643 YACADPSRLKYHMRIHKEERKYLCPECGYKCKWVNQLKYHMTKHTGLKPYQCPECEYCTNRADAL 1707

  Fly   879 --------------------KSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMR- 922
                                |:::....|:.||::|:...|:||..|...|..::.|..|.|..
Mouse  1708 RVHRETRHREARAFMCEQCGKAFKTRFLLRTHLRKHSEAKPYVCNVCHRAFRWAAGLRHHALTHT 1772

  Fly   923 -RH--FDEVEAWLRRQK 936
             ||  |..:.::..:||
Mouse  1773 DRHPFFCRLCSYKAKQK 1789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	19/90 (21%)
		C2H2 Zn finger	206..227	CDD:275368	6/22 (27%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..447	CDD:275368	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368	6/26 (23%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	6/20 (30%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	5/21 (24%)
		C2H2 Zn finger	698..715	CDD:275368	4/16 (25%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	5/19 (26%)
		zf-H2C2_2	802..825	CDD:290200	11/22 (50%)
		COG5048	814..>886	CDD:227381	28/100 (28%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	8/24 (33%)
		C2H2 Zn finger	846..866	CDD:275368	7/19 (37%)
		zf-H2C2_2	859..883	CDD:290200	13/52 (25%)
		C2H2 Zn finger	874..894	CDD:275368	7/48 (15%)
		C2H2 Zn finger	902..924	CDD:275368	6/23 (26%)
Zfp142	NP_001297597.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..357
		COG5048	335..781	CDD:227381	12/48 (25%)
		C2H2 Zn finger	365..385	CDD:275368
		C2H2 Zn finger	393..413	CDD:275368
		C2H2 Zn finger	421..438	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	545..566	CDD:275368
		C2H2 Zn finger	574..595	CDD:275368
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
		C2H2 Zn finger	687..707	CDD:275368
		C2H2 Zn finger	714..731	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..888		10/71 (14%)
		rne	<866..>1015	CDD:236766	28/151 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1103..1177		15/88 (17%)
		C2H2 Zn finger	1267..1296	CDD:275368	6/28 (21%)
		C2H2 Zn finger	1333..1354	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1362..1382	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1390..1411	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1448..1469	CDD:275368	6/27 (22%)
		C2H2 Zn finger	1490..1508	CDD:275368	4/17 (24%)
		C2H2 Zn finger	1516..1536	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1582..1602	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1610..1630	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1638..1658	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1666..1686	CDD:275368	7/19 (37%)
		zf-H2C2_2	1679..1703	CDD:372612	12/23 (52%)
		C2H2 Zn finger	1694..1715	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1723..1743	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1751..1771	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1779..1799	CDD:275368	2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1795..1843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7893
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950