Protein Alignment CG18476 and Zfp735

DIOPT Version :10

• Sequence 1: NP_731615.1
• Gene: CG18476 / 41404
• FlyBaseID: FBgn0037931
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_001119961.1
• Gene: Zfp735 / 76390
• MGIID: 1923640
• Length: 734
• Species: Mus musculus
• Alignment Length: 879
• Identity: 196/879 - (22%)
• Similarity: 320/879 - (36%)
• Gaps: 232/879 - (26%)

  Fly    96 DCLQEAPMELCAEQHVE--VKLETEDEDCGENDVTITCSELPEPDETDMESKKSVDP-LTMIETV 157
            :||..|...|..:..:|  :.|.:......:.:|.|...:..||...|.|..:..:| |....|.
Mouse    23 ECLDSAKRALYRDVMLENYINLVSVGVAVSKQEVIICLEQNKEPWIVDGEKTEVREPALDCNRTK 87

  Fly   158 KL------------EMEPRSVEKPAYDDPTSDF--------------EDEDSLDNLPLYNRIQKW 196
            ||            |:.||......:|.....|              .:.|.|..|.|...:.|:
Mouse    88 KLLPKVCTQNYFQKEITPRFGLNGLFDLYRKKFWEYRAGSEEHEICNYENDLLPFLQLDASLGKF 152

  Fly   197 KTGRKSVYKCHDCPR---SFKRFDFLKRHEMRVHKPETRLYDCSLCI---RKFSRSEALEAHLKI 255
               .:.:.||:...|   :.||..::.:|....|...:.:.|.:..:   |:|.|.|.:..:.:.
Mouse   153 ---LQQLLKCNSVQRNTKTLKRDIWVNKHTSLKHLLSSMVLDNTSTLYEERRFWRREKITEYHQC 214

  Fly   256 HRNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIV------- 313
            .|...:|.            |:|.:|              .|::.|...||::|..:.
Mouse   215 ERYFSKSL------------LHLPQP--------------LNRVYDKFYHLDQHKKVSTYAVKLG 253

  Fly   314 -----SLCGRPN-MEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLD 372
                 |.||..| :..:.:..:..|..|.....||         .||..:..:|...|.:|..|.
Mouse   254 IYHMGSSCGNSNRVNDNNIGYIKNPFLKYYQNNQL---------GGILYQGNNILYDSHHETILS 309

  Fly   373 SSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGR 437
            .:.....:..::.:...|:.:|...:.|  :.||:......|||..::|
Mouse   310 KNVISKPILENYYNHDSRQARSNHCSQS--ILQQQDHTTENLYDILKES---------------- 356

  Fly   438 FVSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQTFECSECKRVFDKKKS 502
             ::|||   :|.:..:....|:.|                                    |..::
Mouse   357 -LTLQL---YNRTWTKGDTNRYTC------------------------------------DIYRN 381

  Fly   503 LTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLK---EHDIPLAETLIAATSRPNGAK 564
            ..:..|.:..:.                   :||:|:..|.   :..:.....:|...|..|...
Mouse   382 ALIESLYLERDN-------------------IKHIKKLFLAPGYDKSLNFNSNIIQYDSNHNEKG 427

  Fly   565 RITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESG---FELQLEDSETEDEM 626
            ....|:....|..:.:|..|..|.::   ..|..|..|...| :..||   ||.:.:..::
Mouse   428 IQNARVHIYSFSNVSNLLGHSNLSVE---EKHSKYKPPGKCS-SKPSGLMVFETRGKSWKS---- 484

  Fly   627 QPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDC--IFKCVSKSIMDHHRQGQC 689
                       |..|. :|..::..:|:...:|.. |.|..|.||  :|...|| :..|||   .
Mouse   485 -----------CMQCG-KCFAQYSALQNPHRIHTV-KKPFSCKDCLKLFTWSSK-LQAHHR---I 532

  Fly   690 SSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCP 754
            .:.::.:...||...||...||..|..:.         |||:.                  .:|.
Mouse   533 HTAQELYKSNKCGESFMQSSNLLAHQRIH---------TGDKP------------------YKCN 570

  Fly   755 HCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCD 819
            .|.:.:...|.|..|.| || .||       |.:.|:.||.....:::|..|.|.|||:||::|:
Mouse   571 KCGKYFTRSSNLQVHQR-VH-TGD-------KPYECNKCGKSFTQSSSLKIHHRIHTGDKPYRCN 626

  Fly   820 LCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQA 884
            .|...|.|.|.|..|:|:|||:||:.|..|||.|.:|..||.|...|:|.||:||..|.||:.|:
Mouse   627 ECGKCFIRSSNLKVHQRVHTGDKPYKCNECGKSFTQSSSLKVHHKIHTGDKPYKCNECGKSFIQS 691

  Fly   885 KDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKH 918
            .|||.|.:.|||:.|:.|..||:.|.|.|.|:.|
Mouse   692 SDLKNHYRIHTGDKPYKCNECGKSFRQCSDLKNH 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	C2H2 Zn finger	206..227	CDD:275368	5/23 (22%)
		C2H2 Zn finger	236..256	CDD:275368	4/22 (18%)
		C2H2 Zn finger	401..422	CDD:275368	5/20 (25%)
		C2H2 Zn finger	431..447	CDD:275368	3/15 (20%)
		C2H2 Zn finger	461..481	CDD:275368	1/19 (5%)
		C2H2 Zn finger	490..511	CDD:275368	2/20 (10%)
		C2H2 Zn finger	520..540	CDD:275368	3/19 (16%)
		C2H2 Zn finger	638..659	CDD:275368	4/20 (20%)
		C2H2 Zn finger	668..690	CDD:275368	9/23 (39%)
		C2H2 Zn finger	698..715	CDD:275368	6/16 (38%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		COG5048	814..>886	CDD:227381	34/71 (48%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		C2H2 Zn finger	846..866	CDD:275368	9/19 (47%)
		C2H2 Zn finger	874..894	CDD:275368	9/19 (47%)
		C2H2 Zn finger	902..924	CDD:275368	8/17 (47%)
Zfp735	NP_001119961.1	KRAB	8..68	CDD:214630	10/44 (23%)
		C2H2 Zn finger	485..505	CDD:275368	4/20 (20%)
		C2H2 Zn finger	513..533	CDD:275368	9/23 (39%)
		COG5048	<529..725	CDD:227381	82/234 (35%)
		C2H2 Zn finger	542..561	CDD:275368	7/18 (39%)
		C2H2 Zn finger	569..589	CDD:275368	6/20 (30%)
		C2H2 Zn finger	597..617	CDD:275368	6/19 (32%)
		C2H2 Zn finger	625..645	CDD:275368	8/19 (42%)
		C2H2 Zn finger	653..673	CDD:275368	9/19 (47%)
		C2H2 Zn finger	681..701	CDD:275368	9/19 (47%)
		C2H2 Zn finger	709..729	CDD:275368	8/17 (47%)