DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Zfp974

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001360956.1	Gene:	Zfp974 / 73430	MGIID:	1920680	Length:	826	Species:	Mus musculus

Alignment Length:	958	Identity:	228/958 - (23%)
Similarity:	352/958 - (36%)	Gaps:	277/958 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 CSGCTKKLMGAYCYVKQAMAANELLMKHLKNGAAPTSTDCLQEAPMELCAEQHVEVKLETEDEDC 122
            |...|:|::           ..:::::...|..:...: |:.:..:.:..||..|..:..::|
Mouse    30 CLDATQKVL-----------YRDMMLETYSNLVSVVGS-CISKPDLIVLLEQEKEPWMAVKEE-- 80

  Fly   123 GENDVTITCSELPEPD-ETDMES---------------KKSVDPLTMI----------------- 154
                     ::.|.|| |||.::               |:|:..|:.|
Mouse    81 ---------TDRPSPDLETDYDAGSISPENSISNGNFPKQSIKQLSRILDLEGSTFSNGHNHSIF 136

  Fly   155 --------------ETVKLEMEPRSVEKPAY--DDPTSDFEDEDSLDNLPLYNRIQKWKTGRKSV 203
                          .|.|.||.|.:.:..|:  :.|....|..........:.:.|...||.|.
Mouse   137 SGLQGYKGGDAGQKVTKKEEMPPYTCQTLAHNTEKPYECKECGKCFGCRSTFTQHQSIHTGEKP- 200

  Fly   204 YKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEALEAHLKIHRNSKRSANISEH 268
            |:|.:|.::|:....|.||: :.|..| :.::|:.|.:.|...:.|:.|..||.
Mouse   201 YECEECGKAFRLPQQLTRHQ-KFHSGE-KPFECNECGKAFHLPDLLKYHKTIHT----------- 252

  Fly   269 KKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVSLCG-----RPNMEPHELAE 328
                          |.|..||..| ..|..|     |.:..|...|.||     |.|:..|:
Mouse   253 --------------GEKPFECREC-GLYRII-----HADVKPYKCSECGKAFKRRSNLVQHQ--- 294

  Fly   329 LFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDSDLDGDHDDQHKRRKK 393
                  |..|:|:....  ||...|    |..:...:                 .|.:.|...|
Mouse   295 ------KTHSDERPFQC--KDCGKG----FIVLAQLT-----------------RHQNIHTGEK- 329

  Fly   394 SRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNESQCRNAQKR 458
                ::.|..|.:.|....||..||: ||| .:.|..|..|...|....||::|  .....:.|.
Mouse   330 ----SFECHECGKAFRLPQQLTRHQK-SHS-GEKPFKCNECGKAFHLPDLLKYH--KTIHTSTKP 386

  Fly   459 FLCHKCPLRFRWKHNLKTHFREHRITN---QTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPC 520
            |.|.:|...|....||.    |||:.:   :..:|:||.:.|.:.|||..| ..:|:.| :...|
Mouse   387 FECRECGKSFHRISNLV----EHRLIHADVKPHKCNECGKAFKRNKSLMQH-QKIHSGE-RPFQC 445

  Fly   521 QWCSRKFYRHDYLVKHLKRH-----GLKEHD-------IPLAETLIAATSRPNGAKRITCRMCNL 573
            |.|.:.|    .::.||.||     |.|..:       ...|..|:...|...|.|...|.:|..
Mouse   446 QECGKAF----IVLAHLTRHQTIHTGEKSFECKECGKKFRTATHLVQHQSIHTGEKPFECNVCGK 506

  Fly   574 HFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESG--FELQL---EDSETEDEMQPGVGSR 633
            .|            .|::.||.||.......:...|..|  |.||:   |..:|..|.:|
Mouse   507 AF------------RLQIYLSEHQKTHMEAKHFECNICGKVFRLQVYLSEHQKTHTEEKP----- 554

  Fly   634 PVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSK--SIMDHHRQGQCSSTEKK- 695
              :.|:||....:.|:::.:| .|:|. |:.|::|.:| .||..:  :..||    |...|.||
Mouse   555 --FKCKLCGSAFRSKYQLSKH-HTVHT-DEKPYQCKEC-GKCFRQRSNFTDH----QSIHTGKKP 610

  Fly   696 HACGKCSYKFMWPENLEQHILLQHSKS-SVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRT 759
            ..|.:|. ||.....|    |::|.|| |...|                       .:|..|.:.
Mouse   611 FQCKECG-KFYRLNTL----LIRHQKSHSSERP-----------------------YECKECGKA 647

  Fly   760 YQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMA 824
            :.:.|.|||| :.||.:.        :.|.|.:||...:..:.|:.||..|:|.|.::|..|...
Mouse   648 FHLPSELNNH-QIVHTSN--------RPFECKVCGKSFKRESTLIQHMAIHSGVKSYECKECGKG 703

  Fly   825 FPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYR------- 882
            |...|.|..||::|:.||||.|..|||.|.....|.||...|:|.|..:|.:|..::|
Mouse   704 FIHRSSLLHHRKIHSDEKPFKCQECGKAFVVLAYLTRHQSIHTGEKSFECQHCGSAFRYKSQLSK 768

  Fly   883 ---------------------QAKDLKLHLQQHTGECPFVCGTCGERF 909
                                 ...||::|...||.|.||.|...||.|
Mouse   769 HQRIHTDVRLFQCMEGRNDFVHGLDLRIHQGIHTSETPFQCNEYGEPF 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	3/25 (12%)
		C2H2 Zn finger	206..227	CDD:275368	6/20 (30%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..422	CDD:275368	7/20 (35%)
		C2H2 Zn finger	431..447	CDD:275368	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		C2H2 Zn finger	490..511	CDD:275368	8/20 (40%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	6/20 (30%)
		C2H2 Zn finger	668..690	CDD:275368	7/23 (30%)
		C2H2 Zn finger	698..715	CDD:275368	5/16 (31%)
		C2H2 Zn finger	753..774	CDD:275368	7/20 (35%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	8/22 (36%)
		COG5048	814..>886	CDD:227381	27/99 (27%)
		C2H2 Zn finger	818..838	CDD:275368	7/19 (37%)
		zf-H2C2_2	830..855	CDD:290200	13/24 (54%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		zf-H2C2_2	859..883	CDD:290200	9/51 (18%)
		C2H2 Zn finger	874..894	CDD:275368	6/47 (13%)
		C2H2 Zn finger	902..924	CDD:275368	4/8 (50%)
Zfp974	NP_001360956.1	KRAB	14..75	CDD:214630	8/56 (14%)
		C2H2 Zn finger	175..195	CDD:275368	2/19 (11%)
		COG5048	199..574	CDD:227381	116/479 (24%)
		C2H2 Zn finger	203..223	CDD:275368	6/20 (30%)
		C2H2 Zn finger	231..251	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/28 (25%)
		C2H2 Zn finger	305..325	CDD:275368	5/42 (12%)
		C2H2 Zn finger	333..353	CDD:275368	7/20 (35%)
		C2H2 Zn finger	361..381	CDD:275368	6/21 (29%)
		C2H2 Zn finger	389..409	CDD:275368	8/23 (35%)
		COG5048	411..781	CDD:227381	117/438 (27%)
		C2H2 Zn finger	417..437	CDD:275368	8/20 (40%)
		C2H2 Zn finger	445..465	CDD:275368	8/23 (35%)
		C2H2 Zn finger	473..493	CDD:275368	3/19 (16%)
		C2H2 Zn finger	501..521	CDD:275368	8/31 (26%)
		C2H2 Zn finger	529..549	CDD:275368	6/19 (32%)
		C2H2 Zn finger	557..577	CDD:275368	6/20 (30%)
		C2H2 Zn finger	585..605	CDD:275368	7/24 (29%)
		C2H2 Zn finger	613..633	CDD:275368	8/24 (33%)
		C2H2 Zn finger	641..661	CDD:275368	7/20 (35%)
		C2H2 Zn finger	669..689	CDD:275368	6/19 (32%)
		C2H2 Zn finger	697..717	CDD:275368	7/19 (37%)
		C2H2 Zn finger	725..745	CDD:275368	8/19 (42%)
		C2H2 Zn finger	753..773	CDD:275368	3/19 (16%)
		C2H2 Zn finger	781..801	CDD:275368	3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030